Korean J Pathol.  2011 Jul;45(Suppl 1):S58-S61. 10.4132/KoreanJPathol.2011.45.S1.S58.

Angiomyomatous Hamartoma of Popliteal Lymph Nodes Occurring in Association with Diffuse Pigmented Villonodular Synovitis of Knee

• Kim HS
• Na KY
• Lee JH
• Cho NS
• Kim GY
• Lim SJ

• KMID: 1443664
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.S1.S58

Abstract

We report the first case of an angiomyomatous hamartoma (AH) of the popliteal lymph nodes (LNs) occurring in association with diffuse pigmented villonodular synovitis (PVNS) of the knee. AH is a rare benign vascular disease with a predisposition for the LNs of the inguinal region. Twenty-five cases of AH have been reported to date; however, the precise pathogenesis is still undetermined. In the present case, an open synovectomy revealed two of three popliteal LNs in close proximity to the extra-articular component of diffuse PVNS. These LNs demonstrated irregularly distributed thick-walled blood vessels in the hilum. These vessels extended into the medulla and cortex and were associated with haphazardly arranged smooth muscle cells in the sclerotic stroma. These findings are compatible with an AH. Our observations raise the possibility that AH of the popliteal LNs may represent an abnormal proliferative reaction against the inflammatory process caused by PVNS of the knee.

Keyword

Angiomyoma; Hamartoma; Popliteal; Lymph nodes; Synovitis, pigmented villonodular

MeSH Terms

Angiomyoma
Blood Vessels
Hamartoma
Knee
Lymph Nodes
Myocytes, Smooth Muscle
Synovitis, Pigmented Villonodular
Vascular Diseases