Korean J Pathol.  2011 Jul;45(Suppl 1):S32-S35. 10.4132/KoreanJPathol.2011.45.S1.S32.

Diffuse Pulmonary Meningotheliomatosis: A Case Report

• An J
• Park H
• Han J
• Kim TS
• Choi YS
• Choi MS
• Um SW

• KMID: 1443658
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.S1.S32

Abstract

Diffuse pulmonary meningotheliomatosis (DPM) is an extremely rare condition. We herein report a unique case of DPM in a 54-year-old woman with a previous history of hepatocellular carcinoma. A chest computed tomography showed diffuse bilateral nodular infiltration, suggesting miliary spread of metastatic hepatocellular carcinoma. The patient underwent a video-assisted thoracoscopic surgery for diagnostic purposes. The cut surface of the lung specimen showed multiple dispersed small nodules, consisting of variably sized nests or whorls of bland epithelioid cells often along the walls of alveolar septa or in a perivascular network within the alveolar interstitium. The tumor cells showed immunoreactivity for epithelial membrane antigen, vimentin, and progesterone receptor. DPM should be included in the differential diagnosis of diffuse multiple small nodules or a reticular pattern in the radiologic studies.

Keyword

Lung; Meningioma; Lung neoplasms

MeSH Terms

Carcinoma, Hepatocellular
Diagnosis, Differential
Epithelioid Cells
Female
Humans
Lung
Lung Neoplasms
Meningioma
Middle Aged
Mucin-1
Receptors, Progesterone
Thoracic Surgery, Video-Assisted
Thorax
Vimentin
Mucin-1
Receptors, Progesterone
Vimentin