J Korean Soc Radiol.  2011 Jan;64(1):83-86. 10.3348/jksr.2011.64.1.83.

Invasive Cribriform Carcinoma of the Breast: A Case Report

• Heo TW
• Lim HS
• Lee JS
• Park MH
• Jeong SJ
• Kim JW
• Park JG
• Kang HK

• KMID: 1443587
• DOI: http://doi.org/10.3348/jksr.2011.64.1.83

Abstract

Invasive cribriform carcinoma is a rare type of invasive breast carcinoma with an excellent prognosis and is characterized by a cribriform histological pattern. However, there is scant information about the radiologic features of invasive cribriform carcinoma of the breast. We report a case of invasive cribriform carcinoma of the breast with radiologic features including MR imaging findings.

MeSH Terms

Adenocarcinoma
Breast
Breast Neoplasms
Magnetic Resonance Imaging
Prognosis

Figure

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  Fig. 1 Invasive cribriform carcinoma of the breast in a 48-year-old woman. A. Sonogram shows a 0.9-cm, microlobulated isoechoic mass (arrows) in the left breast at a 1-o'clock position. B, C. The mass (arrow) has an iso-signal intensity on a fat-saturated T1 weighted image (B) and an iso- to slightly high signal intensity on a fat-saturated T2 weighted image (C). D, E. Images reveal oval, smooth early enhancement (arrow) on fat-saturated T1 weighted subtraction images after contrast infusion (D) and show an initial rapid rise and delayed washout pattern in the kinetic curve (E). F. Microscopic examination (hematoxylin-eosin stain, original magnification ×100) shows invasive carcinoma with a cribriform pattern. The nests are punctuated by uniform punched-out spaces.

Reference

1. Page DL, Dixon JM, Anderson TJ, Lee D, Stewart HJ. Invasive cribriform carcinoma of the breast. Histopathology. 1983; 7:525–536.

2. Cribriform carcinoma. In : Rosen PP, editor. Rosen's breast pathology. 2nd Ed. Philadelphia: Lippincott Williams & Wilkins;2001. p. 551–553.

3. Stutz JA, Evans AJ, Pinder S, Ellis IO, Yeoman LJ, Wilson AR, et al. The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. Clin Radiol. 1994; 49:693–669.

4. Nishimura R, Ohsumi S, Teramoto N, Yamakawa T, Saeki T, Takashima S. Invasive cribriform carcinoma with extensive microcalcifications in the male breast. Breast Cancer. 2005; 12:145–148.

5. Venable JG, Schwartz AM, Silverberg SG. Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity. Hum Pathol. 1990; 21:333–338.

6. Marzullo F, Zito FA, Marzullo A, Labriola A, Schittulli F, Gargano G, et al. Infiltrating cribriform carcinoma of the breast. A clinicopathologic and immunohistochemical study of 5 cases. Eur J Gynaecol Oncol. 1996; 17:228–223.

7. Wells CA, Ferguson DJ. Ultrastructural and immunocytochemical study of a case of invasive cribriform breast carcinoma. J Clin Pathol. 1988; 41:17–20.