J Korean Med Sci.  2004 Feb;19(1):149-151. 10.3346/jkms.2004.19.1.149.

Invasive Cystic Hypersecretory Carcinoma of the Breast: A Case Report

• Lee JS
• Lee YJ

• KMID: 1785712
• DOI: http://doi.org/10.3346/jkms.2004.19.1.149

Abstract

Cystic hypersecretory lesions of the breast are rare. These breast lesions include cystic hypersecretory hyperplasia (CHH), atypical CHH, and cystic hypersecretory carcinoma (CHC). The characteristic features are dilated ducts and cysts filled with thyroid colloid-like eosinophilic secretion. Only seven cases of invasive CHC have been reported in the literature. Here, we report an additional case of invasive CHC. The histologic features of the tumor showed both micropapillary intraductal carcinoma and focal high-grade invasive carcinoma in a background of CHH. This case suggests that cystic hypersecretory breast lesions encompass a spectrum of pathologic lesions including CHH, atypical CHH, CHC, and invasive CHC.

Keyword

Breast; Neoplasms; Carcinoma; Cystic Hypersecretory Carcinoma; Cystic Hypersecretory Hyperplasia

MeSH Terms

Breast Neoplasms/*pathology
Carcinoma/*pathology
Carcinoma, Intraductal, Noninfiltrating/pathology
Cell Differentiation
Eosinophils/pathology
Female
Fibrocystic Disease of Breast/pathology
Human
Hyperplasia
Immunohistochemistry
Middle Aged
Neoplasm Invasiveness

Figure

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  Fig. 1 The cut surface of the mass shows numerous cysts, measuring up to 1.2 cm in diameter, with a gelatinous secretion.

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  Fig. 2 Microscopic findings. The lesion is composed of multiple cysts and ducts containing eosinophilic secretion (A, H&E, ×20). Most of the cysts are lined by flat epithelium. The secretion retracts from the surrounding epithelium (B, H&E, ×200). The epithelium of some cysts grows as micropapillary intraductal carcinoma (C, H&E, ×200). An invasive component (arrow) is found adjacent to the intraductal carcinoma component (D, H&E, ×100).

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