Int J Stem Cells.  2012 May;5(1):12-15.

Cancer Stem Cells in Brain Tumors and Their Lineage Hierarchy

Affiliations
  • 1Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. kds026@skku.edu

Abstract

Despite recent advances in the development of novel targeted chemotherapies, the prognosis of malignant glioma remains dismal. The chemo-resistance of this tumor is attributed to tumor heterogeneity. To explain this unique chemo- resistance, the concept of cancer stem cells has been evoked. Cancer stem cells, a subpopulation of whole tumor cells, are now regarded as candidate therapeutic targets. Here, the author reviews and discusses the cancer stem cell concept.

Keyword

Cell of origin; Cancer stem cell; Lineage hierarchy

MeSH Terms

Brain
Brain Neoplasms
Glioma
Neoplastic Stem Cells
Population Characteristics
Prognosis
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