Yonsei Med J.  2009 Oct;50(5):713-716. 10.3349/ymj.2009.50.5.713.

False Positive Immunoglobulin M Antibody to Cytomegalovirus in Child with Infectious Mononucleosis Caused by Epstein-Barr Virus Infection

• Park JM
• Shin JI
• Lee JS
• Jang YH
• Kim SH
• Lee KH
• Lee CH

• KMID: 1103828
• DOI: http://doi.org/10.3349/ymj.2009.50.5.713

Abstract

A 16-month-old boy was admitted because of cough that had lasted for 10 days. The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus (CMV). On the basis of seroconversion to Epstein-Barr nuclear antigen (EBNA) Ig G positivity and reduced CMV Ig M titer with persistently negative CMV Ig G, a definite diagnosis of EBV-induced infectious mononucleosis was established 1 year 2 month later.

Keyword

Hepatomegaly; Epstein-Barr virus; cytomegalovirus

MeSH Terms

Antibodies, Viral/immunology
Cytomegalovirus/*immunology
False Positive Reactions
Herpesvirus 4, Human/*immunology
Humans
Immunoglobulin M/*blood
Infant
Infectious Mononucleosis/*diagnosis/virology
Male

Figure

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  Fig. 1 Plain X-ray finding of hepatomegaly.

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  Fig. 2 Computed tomography finding of hepatomegaly.

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  Fig. 3 Comparision of sonographic findings between first time (A) and 14 months later (B). Sonography at first time (A) shows increased hepatic echogenicity with diffuse enlargement. Follow-up sonography (B) shows improvement of hepatomegaly with normal hepatic echogenicity.

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