Pediatr Gastroenterol Hepatol Nutr.  2013 Mar;16(1):61-64. 10.5223/pghn.2013.16.1.61.

Epstein-Barr Virus Infection with Acute Pancreatitis Associated with Cholestatic Hepatitis

• Kang SJ
• Yoon KH
• Hwang JB

• KMID: 1428809
• DOI: http://doi.org/10.5223/pghn.2013.16.1.61

Abstract

Infection-induced acute hepatitis complicated with acute pancreatitis is associated with hepatitis A virus, hepatitis B virus or hepatitis E virus. Although rare, Epstein-Barr virus (EBV) infection should be considered also in the differential diagnosis if the patient has acute hepatitis combined with pancreatitis. We report a case of EBV infection with cholestatic hepatitis and pancreatitis with review of literature. An 11-year-old female was admitted due to 1-day history of abdominal pain and vomiting without any clinical symptoms of infectious mononucleosis. Diagnosis of reactivated EBV infection was made by the positive result of viral capsid antigen (VCA) IgM, VCA IgG, Epstein-Barr nuclear antigen and heterophile antibody test. We performed serologic tests and magnetic resonance cholangiopancreatography to exclude other viral or bacterial infection, autoimmune disorder, and structural problems. The patient's symptoms recovered rapidly and blood chemistry returned to normal with conservative treatment similar to previously reported cases.

Keyword

Cholestasis; Epstein-Barr virus; Hepatitis; Pancreatitis

MeSH Terms

Abdominal Pain
Bacterial Infections
Capsid
Cholangiopancreatography, Magnetic Resonance
Cholestasis
Diagnosis, Differential
Epstein-Barr Virus Infections
Female
Hepatitis
Hepatitis A virus
Hepatitis B virus
Hepatitis E virus
Herpesvirus 4, Human
Humans
Immunoglobulin G
Immunoglobulin M
Infectious Mononucleosis
Pancreatitis
Serologic Tests
Vomiting
Immunoglobulin G
Immunoglobulin M