J Korean Med Sci.  2003 Dec;18(6):779-782. 10.3346/jkms.2003.18.6.779.

Comparison of Mortality and Morbidity in Multiple versus Singleton Very Low Birth Weight Infants in A Neonatal Intensive Care Unit

  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. wspark@smc.samsung.co.kr
  • 2Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.


Multiple births in Korea have been increased recently as a consequence of increased infertility due to advancing maternal age at first birth, and increased use of assisted reproductive technology. Multiples suffer higher mortality and morbidity than singletons. However, it is not clear whether preterm multiple very low birth weight infants (VLBWI) suffer higher mortality and morbidity than comparable singletons. We evaluated 266 singleton and 113 multiple VLBWI to determine whether mortality and morbidity in multiple VLBWI were higher than those in comparable singletons. The rate of in vitro ertilization and cesarean section were significantly higher in multiples than singletons. The total and the adjusted mortality with gestational age and birth weight were not significantly different between the two groups. Maternal age and the incidence of respiratory distress syndrome, patent ductus arteriosus, bronchopulmonary dysplasia, intracranial hemorrhage (grade> or=3), cystic periventricular leukomalacia, and retinopathy of prematurity (stage> or=3) were not significantly different between the two groups, and the incidence of abnormal brainstem auditory evoked potential was higher among the singletons. These results suggest that multiple VLBWI do not suffer higher mortality or morbidity than comparable singletons.


Multiple Birth Offspring; Infant; Very Low Birth Weight; Mortality; Morbidity

MeSH Terms

Birth Weight
Comparative Study
Gestational Age
*Infant Mortality
Infant, Newborn
*Infant, Very Low Birth Weight
*Intensive Care Units, Neonatal
Maternal Age
*Pregnancy Outcome
*Pregnancy, Multiple
Retrospective Studies
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