- Light and electron microscopic study on dendrotoxic effect of kainic acid in hippocampus of rat brain
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Choi JY, Kim KY, Lee WB, Kim DC
- KMID: 1686603
- Korean J Anat.
- 1993 Dec;26(4):401-415.
No abstract available. -
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- Effects of kainic Acid-induced seizures on GABA and GABA transporter in the cerebellum of the rat
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Hong H, Lee J, Im J, Hwang S, Kim D
- KMID: 1530634
- Korean J Anat.
- 1999 Dec;32(6):837-847.
The effects of kainic acid-induced seizures on GABA and GABA transporter in the rat cerebellum were examined by means of immunohistochemical and Western blot methods. Immunocytochemical analysis showed that kainic... -
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- Excitotoxic change of Hippocampal Neuron by Kainic Acid in Rat Brain
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Chang SH, Kim DE, Kwon OS, Kim KY, Lee WB, Kim DC
- KMID: 2342431
- J Korean Neurol Assoc.
- 1994 Sep;12(3):382-396.
The excitotoxic effect of kainic acid on dendrites and neuronal cell bodies of hippocampus and dentate gyrus was studied with time (1, 4, 8, 16 hours, 2, 7, 14 days)... -
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- Electroencephalographic, Behavioral and Pathologic Characteristics in Experimental Complex Partial Seizure Induced by Microinjection of Kainic Acid into the Unilateral Amygdala in the Rat
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Choi HY, Kim BI, Kim HI, Lee JC
- KMID: 2187830
- J Korean Neurosurg Soc.
- 1993 Feb;22(2):287-299.
Kainic acid(KA) is an excitotoxic analogue of glutamate which is now widely used in the studies of epilepsy. Electroencephalographic, behavioral and pathologic observation were done for 2 months after microinjection... -
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- Regulation of MAPK Activity by Seizure-induced MKP-1 in Rat Hippocampus
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Yu BH, Kang UG, Ahn YM, Chung SJ, Jeon SH, Park JB, Kim YS
- KMID: 2340347
- J Korean Neuropsychiatr Assoc.
- 1999 Jul;38(4):873-880.
OBJECTIVES: Both electroconvulsive shock(ECS) and kainic acid-induced seizures activate mitogenactivated protein kinases(MAPKs)in rat hippocampus. They can also induce the expression of MAPK phosphatase-1(MKP-1)in rat hippocampus. MKP-1 is known as... -
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- Protective Effect of Etomidate on Kainic Acid-induced Neurotoxicity in Rat Hippocampus
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Lee EJ, Kim JU, Gwak MJ, Han SM, Lee JW, Hong HN, Kim D
- KMID: 1936257
- Korean J Anesthesiol.
- 2001 Jun;40(6):794-801.
- doi: 10.4097/kjae.2001.40.6.794
BACKGROUND: The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by using the immunoreactivity of heat shock protein-70 (HSP-70)... -
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- Kainic Acid Treatment Increases Ca²âº-mediated Neurotoxicity in the Mouse Hippocampus
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Lee JE
- KMID: 2328103
- Korean J Phys Anthropol.
- 2016 Jun;29(2):71-79.
- doi: 10.11637/kjpa.2016.29.2.71
Kainic acid (KA)-induced neuronal cell death is associated with intracellular Ca²⺠influx. However, it is unknown whether Lyn/Btk pathway is involved in the Ca²âº-mediated neurotoxicity and neuronal death induced by... -
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- Identification of Differentially Expressed Genes in Murine Hippocampus by Modulation of Nitric Oxide in Kainic Acid-induced Neurotoxic Animal Model
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Suh YA, Kwon OM, Yim SY, Lee HJ, Kim SS
- KMID: 1512895
- Korean J Physiol Pharmacol.
- 2007 Aug;11(4):149-154.
Kainic acid (KA) causes neurodegeneration, but no consensus has been reached concerning its mechanism. Nitric oxide may be a regulator of the mechanism. We identified differentially expressed genes in the... -
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- Changes in somatostatin immunoreactive neurons in rat cerebral cortex after systemic kainic acid administration
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Lee MY, Chung SJ, Ahn CI
- KMID: 1945909
- J Korean Pediatr Soc.
- 1993 Sep;36(9):1279-1290.
This study was aimed to clarify the effects of systemic kainic acid (KA) administration (10 mg/kg i.p.) on somatostatin containing neurons, and to examine the distribution of somatostain immunoreactive neurons... -
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- Neuroprotection by 1,25(OH)2-Vitamin D3 Against Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus
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Choi JY, Lee KS, Kim YI
- KMID: 1572457
- J Korean Neurol Assoc.
- 2006 Jun;24(3):245-251.
BACKGROUND: The neuroprotective effects of 1,25-dihydroxyvitamin D3 on neurotoxicity have already been documented. However, the mechanisms underlying these effects are not fully understood. Extracellular signal-regulated kinase (ERK), one of the... -
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- The Stereotaxic Injection of Kainic Acid into Corpus Striatum: Destruction of Neuron with Sparing Axon
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Ahn BC, Kim DE, Kwon OS, Kim KY, Lee WB, Kim DC
- KMID: 2065921
- J Korean Neurol Assoc.
- 1991 Sep;9(3):315-322.
The ultrastructure of the excitotoxic lesion similar to that occurring in the degenerative neuronal disease was produceby stereotaxic injections of 1 nmol and 10 mnol of kainic acid nto the... -
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- Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex
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Rim HJ, Ha JH, Lee JS, Hyun I, Uh KB
- KMID: 1384293
- Korean J Parasitol.
- 1974 Dec;12(2):141-146.
- doi: 10.3347/kjp.1974.12.2.141
A single dose (2.0, 5.0, 10.0 mg/kg) of pyrantel embonate given to three groups consisting 301 children with Ascaris lumbricoides infection achieved a cure rate of 91.3%, 94.4% and 98.9%... -
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- Effect of kainic acid on the phosphorylation of mitogen activated protein kinases in rat hippocampus
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Won JS, Lee JK, Choi SS, Song DK, Huh SO, Kim YH, Suh HW
- KMID: 1607133
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):451-456.
In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide... -
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- Activation of JNK and p38 in rat hippocampus after kainic acid induced seizure
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Jeon SH, Kim YS, Bae CD, Park JB
- KMID: 755104
- Exp Mol Med.
- 2000 Dec;32(4):227-230.
Kainic acid, an analogue of glutamate, causes limbic seizures and induces cell death in the rat brain. We examined the activation of MAPK family kinases; ERKs, JNKs and... -
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- The Effect of Unilateral Dopaminergic Deafferentation on Kainic acid Induced Seizures in the Rat
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Park KW, Lee DH
- KMID: 2066049
- J Korean Neurol Assoc.
- 1996 Mar;14(1):114-125.
There has been quite a number of research regarding the role of dopamine in epilepsy and it has been still very controversial, In this study, the effect of dopaminergic deafferentation... -
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- Effect of Etomidate on the Expressions of c-JUN and Heat Shock Protein 70 Induced by Kainic Acid in Rats
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Lee JH, Lee YM, Chang BJ, Park SJ, Lee JY, Kim JU, Ku SW
- KMID: 2237538
- Korean J Anesthesiol.
- 2004 Aug;47(2):253-259.
- doi: 10.4097/kjae.2004.47.2.253
BACKGROUND: The present investigation was undertaken to evaluate the neuroprotective effect of etomidate against kainic acid (KA) induced neurotoxicity in rats by Western immunoblotting for heat shock protein 70 (HSP-70),... -
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- The Effects of N-Methyl_D-Aspartic Acid, and Antagonism by Kynurenic Acid on Neurons in the Cathish Retina
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Lee SJ, Jung CS, Bai SH
- KMID: 2205353
- J Korean Ophthalmol Soc.
- 1998 Oct;39(10):2303-2312.
To investigate the mechanism of the excitatory signal transmission, the effects of N-methyl-D-aspartate(NMDA, ionotropic glutamate agonist) and kynurenic acid(glutamate antagonist) on catfish retinal neurons were explored using conventional intracellular recording... -
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- ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus
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Lee YS, Kang JW, Lee YH, Kim DW
- KMID: 1447422
- Anat Cell Biol.
- 2011 Jun;44(2):128-134.
- doi: 10.5115/acb.2011.44.2.128
Inhibitor of DNA binding (ID) proteins bind to and inhibit the function of basic helix-loop-helix transcription factors, including those that regulate proliferation and differentiation during development. However, little is known... -
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- The Effect of Androsterone as the Metabolite of Testosterone to Seizure Suppression
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Kim WJ, Lee SY, Cho KJ, Lee BI
- KMID: 2185030
- J Korean Neurol Assoc.
- 2009 May;27(2):142-146.
BACKGROUND: Androsterone is one of the major metabolites from testosterone whose clinical importance remains unclear. This study evaluated the effects of androsterone on seizure susceptibility in mouse models of epilepsy. METHODS:... -
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- Intracerebroventricular Kainic Acid-Induced Damage Affects Blood Glucose Level in d-glucose-fed Mouse Model
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Kim CH, Hong JS
- KMID: 2052849
- Exp Neurobiol.
- 2015 Mar;24(1):24-30.
- doi: 10.5607/en.2015.24.1.24
We have previously reported that the intracerebroventricular (i.c.v.) administration of kainic acid (KA) results in significant neuronal damage on the hippocampal CA3 region. In this study, we examined possible changes... -
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