- Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
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Jung BK, Lee WJ, Kang E, Ahn HM, Kim YO, Rah DK, Yun CO, Yun IS
- KMID: 2375215
- Arch Craniofac Surg.
- 2017 Mar;18(1):9-15.
- doi: 10.7181/acfs.2017.18.1.9
BACKGROUND: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a... -
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- Epithelial-mesenchymal transition in keloid tissue
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Yang CE, Moon SJ, Kim SJ, Lee JH, Yun CO, Lew DH, Lee WJ
- KMID: 2427555
- Arch Plast Surg.
- 2018 Nov;45(6):600-601.
- doi: 10.5999/aps.2017.01214
No abstract available. -
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- Gene Therapy Using Hepatocyte Growth Factor Expressing Adenovirus Improves Skin Flap Survival in a Rat Model
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Rah DK, Yun IS, Yun CO, Lee SB, Lee WJ
- KMID: 2151418
- J Korean Med Sci.
- 2014 Nov;29(Suppl 3):S228-S236.
- doi: 10.3346/jkms.2014.29.S3.S228
Hepatocyte growth factor (HGF) is a potent angiogenic factor that can stimulate the production of blood vessels in ischemic tissue. We investigated whether gene therapy using HGF-expressing adenovirus could enhance... -
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- Effect of Relaxin Expression from an Alginate Gel-Encapsulated Adenovirus on Scar Remodeling in a Pig Model
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Yun IS, Kang E, Ahn HM, Kim YO, Rah DK, Roh TS, Lee WJ, Yun CO
- KMID: 2457481
- Yonsei Med J.
- 2019 Sep;60(9):854-863.
- doi: 10.3349/ymj.2019.60.9.854
PURPOSE: Relaxin (RLX) is a transforming growth factor-β1 (TGF-β1) antagonist that is believed to function as a potent collagen re-arranger and a major suppressor of extracellular matrix components. Adenoviruses (Ads)... -
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- Effect of Relaxin Expressing Adenovirus for Rat Skin Flap Viability
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Yun IS, Park YS, Cheon YW, Jeon YR, Lee WJ, Yun CO, Rah DK
- KMID: 2322266
- J Korean Soc Plast Reconstr Surg.
- 2010 Sep;37(5):519-525.
PURPOSE: Of various effects of relaxin, we assumed that anti-fibrotic effects, neovascularization effects and vasodilatation effects of relaxin might enhance the survival rate of skin flap. In the current study,... -
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- Imaging of Viral Thymidine Kinase Gene Expression by Replicating Oncolytic Adenovirus and Prediction of Therapeutic Efficacy
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Kim EJ, Yoo JY, Choi YH, Ahn KJ, Lee JD, Yun CO, Yun M
- KMID: 2158200
- Yonsei Med J.
- 2008 Oct;49(5):811-818.
- doi: 10.3349/ymj.2008.49.5.811
PURPOSE: We have used a genetically attenuated adenoviral vector which expresses HSVtk to assess the possible additive role of suicidal gene therapy for enhanced oncolytic effect of the virus. Expression... -
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- Activation of transforming growth factor-β and epithelialmesenchymal transition enhance regulatory T cells-mediated metastasis
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Yoon A, Hong J, Yun CO
- KMID: 2509388
- Korean J Transplant.
- 2020 Dec;34(Supple 1):S198.
- doi: 10.4285/ATW2020.PO-1281
Background: Even though substantial portion of patients with melanoma diagnosis are present with distant metastases, the un-derlying oncogenic process remains unclear. Methods: We have hypothesized that regulatory T cells (Tregs) play... -
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- Mesenchymal stem cells enable delivery of an oncolytic adenovirus specifically to the tumor without posing any risk associated with systemic administration of naked virions to the host
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Yoon A, Hong J, Yun CO
- KMID: 2509389
- Korean J Transplant.
- 2020 Dec;34(Supple 1):S199.
- doi: 10.4285/ATW2020.PO-1282
Background: Systemic delivery oncolytic virus to tumors remains a major challenge due to its poor tumor tropism and immunogenicity. Methods: In this regard, we hypothesize that mesenchymal stem cells (MSCs) with... -
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- Development of Hepatoma-Specific Replication Competent Adenovirus
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Ha TY, Kim JH, Kim MJ, Yun CO
- KMID: 2054980
- J Bacteriol Virol.
- 2003 Dec;33(4):371-382.
A prerequisite for the development of a cancer cell selective targeting adenovirus is the generation of adenoviral vectors that lack native receptor binding ability and additionally contain domains redirecting the... -
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- Evaluation of E1B-mutant Replicating Adenoviruses for Cancer Gene Therapy
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Kim JS, Kim JH, Lee HR, Jung KC, Yun CO
- KMID: 2166225
- Cancer Res Treat.
- 2001 Dec;33(6):500-511.
PURPOSE: Gene-attenuated replication-competent adenoviruses are emerging as a promising new modality for the treatment of cancer. In an effort to continually improve upon cancer gene therapy, we have modified gene-... -
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- Enhanced Oncolytic Effect and Anti-Tumor Effect of Replication Competent Adenovirus with Double Mutation in E1A & E1B Regions
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Kim J, Choi KJ, Kim PH, Kim JH, Sohn JH, Yun CO
- KMID: 1574115
- J Bacteriol Virol.
- 2005 Jun;35(2):113-124.
Gene-modified replication-competent adenoviruses (Ads) are emerging as a promising new modality for the treatment of cancer. We have previously shown that E1B 19kDa and E1B 55kDa gene deleted Ad (Ad-deltaE1B19/55)... -
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- Increased Cytopathic Effect of Replicating Adenovirus Expressing Adenovirus Death Protein
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Kim E, Kim JH, Koo T, Sohn JH, Yun CO
- KMID: 2166160
- Cancer Res Treat.
- 2003 Oct;35(5):425-432.
PURPOSE: Replication-competent adenoviruses (Ads) are promising new modalities for the treatment of cancer. Selective replication of a viral agent in tumor may lead to improved efficacy over non-replicating Ads due... -
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- Development of a Conditional Replication Competent Adenovirus, Controlled by the Human Telomerase Promoter (hTERT)
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Kim E, Kim JH, Shin HY, Lee HS, Sohn JH, Yang JM, Kim J, Yun CO
- KMID: 2166177
- Cancer Res Treat.
- 2003 Jun;35(3):191-206.
PURPOSE: This study has been planned to generate a replication-competent adenovirus which replicates in a cancer cell-specific manner, thus minimizing the side effects and toxicity of cancer gene therapy. MATERIALS... -
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- Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines
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Choi SH, Shin HW, Park JY, Yoo JY, Kim DY, Ro WS, Yun CO, Han KH
- KMID: 1717322
- Korean J Hepatol.
- 2010 Sep;16(3):280-287.
- doi: 10.3350/kjhep.2010.16.3.280
BACKGROUND/AIMS: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of... -
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