- Notch1 in Tumor Microvascular Endothelial Cells and Tumoral miR-34a as Prognostic Markers in Locally Advanced Triple-Negative Breast Cancer
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Kim D, Lee J, Kang J, Kim SH, Yoo TK, Oh S, Lee A
- KMID: 2470893
- J Breast Cancer.
- 2019 Dec;22(4):562-578.
- doi: 10.4048/jbc.2019.22.e56
PURPOSE: Triple-negative breast cancer (TNBC) is associated with poor prognosis with limited treatment options. Angiogenesis is known to be involved in the progression of TNBC, and targeting this pathway results... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- Druggable Molecular Targets for the Treatment of Triple Negative Breast Cancer
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Nakhjavani M, Hardingham JE, Palethorpe HM, Price TJ, Townsend A
- KMID: 2458857
- J Breast Cancer.
- 2019 Sep;22(3):341-361.
- doi: 10.4048/jbc.2019.22.e39
Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient expression of estrogen, progesterone,... -
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- Treatment Outcomes of Weakly Positive Hormone Receptor Breast Cancer and Triple-Negative Breast Cancer
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Yoon MR, Rhu JY, Song BJ, Chae BJ, Yoo TK
- KMID: 2451793
- J Breast Dis.
- 2019 Jun;7(1):1-8.
- doi: 10.14449/jbd.2019.7.1.1
PURPOSE: In breast cancer, response to endocrine therapy depends on estrogen receptor and progesterone receptor status. However, poor prognosis is conferred on patients with hormone receptor (HR)-positive breast cancer. We... -
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- Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
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Lee M, Park IA, Heo SH, Kim YA, Gong G, Lee HJ
- KMID: 2449341
- J Pathol Transl Med.
- 2019 May;53(3):180-187.
- doi: 10.4132/jptm.2019.02.08
BACKGROUND: Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to... -
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- Prognostic Role and Clinical Association of Tumor-Infiltrating Lymphocyte, Programmed Death Ligand-1 Expression with Neutrophil-Lymphocyte Ratio in Locally Advanced Triple-Negative Breast Cancer
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Lee J, Kim DM, Lee A
- KMID: 2464411
- Cancer Res Treat.
- 2019 Apr;51(2):649-663.
- doi: 10.4143/crt.2018.270
PURPOSE: Tumor-infiltrating lymphocyte (TIL), programmed death-ligand 1 (PD-L1) expression and neutrophil-to-lymphocyte ratio (NLR) is associated to immunogenicity and prognosis of breast cancer. We analyzed baseline NLR, changes of NLR, TIL,... -
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- Identification of ERBB Pathway-Activated Cells in Triple-Negative Breast Cancer
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Cho SY
- KMID: 2447793
- Genomics Inform.
- 2019 Mar;17(1):e3.
- doi: 10.5808/GI.2019.17.1.e3
Intratumor heterogeneity within a single tumor mass is one of the hallmarks of malignancy and has been reported in various tumor types. The molecular characterization of intratumor heterogeneity in breast... -
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- Use of positron emission tomography-computed tomography to predict axillary metastasis in patients with triple-negative breast cancer
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Youm JH, Chung Y, Yang YJ, Han SA, Song JY
- KMID: 2432612
- Korean J Clin Oncol.
- 2018 Dec;14(2):135-141.
- doi: 10.14216/kjco.18023
PURPOSE: Axillary lymph node dissection (ALND) and sentinel lymph node biopsy (SLNB) are important for staging of patients with node-positive breast cancer. However, these can be avoided in select micrometastatic... -
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- T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer
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Byun KD, Hwang HJ, Park KJ, Kim MC, Cho SH, Ju MH, Lee JH, Jeong JS
- KMID: 2429819
- J Breast Cancer.
- 2018 Dec;21(4):406-414.
- doi: 10.4048/jbc.2018.21.e61
PURPOSE: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is an emerging immune response molecule related to T-cell anergy. There has been tremendous interest in breast cancer targeting immune checkpoint... -
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- miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer
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Yang L, Cai Y, Zhang D, Sun J, Xu C, Zhao W, Jiang W, Pan C
- KMID: 2429815
- J Breast Cancer.
- 2018 Dec;21(4):371-381.
- doi: 10.4048/jbc.2018.21.e60
PURPOSE: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7... -
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- High Cytoplasmic CXCR4 Expression Predicts Prolonged Survival in Triple-Negative Breast Cancer Patients Treated with Adjuvant Chemotherapy
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Shim B, Jin MS, Moon JH, Park IA, Ryu HS
- KMID: 2427519
- J Pathol Transl Med.
- 2018 Nov;52(6):369-377.
- doi: 10.4132/jptm.2018.09.19
BACKGROUND: Chemokine receptor CXC chemokine receptor type 4 (CXCR4) and its ligand CXC motif chemokine 12 (CXCL12; stromal cell-derived factor-1) are implicated in tumor growth, metastasis, and tumor cell-microenvironment interaction.... -
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- ABT-737 ameliorates docetaxel resistance in triple negative breast cancer cell line
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Hwang E, Hwang SH, Kim J, Park JH, Oh S, Kim YA, Hwang KT
- KMID: 2422933
- Ann Surg Treat Res.
- 2018 Nov;95(5):240-248.
- doi: 10.4174/astr.2018.95.5.240
PURPOSE: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). METHODS: Western blot analysis... -
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- Breast Conservation Therapy Versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23
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Kim K, Park HJ, Shin KH, Kim JH, Choi DH, Park W, Ahn SD, Kim SS, Kim DY, Kim TH, Kim JH, Kim J
- KMID: 2424803
- Cancer Res Treat.
- 2018 Oct;50(4):1316-1323.
- doi: 10.4143/crt.2017.575
PURPOSE: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC). MATERIALS... -
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- Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo
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Deng YW, Hao WJ, Li YW, Li YX, Zhao BC, Lu D
- KMID: 2421365
- J Breast Cancer.
- 2018 Sep;21(3):251-258.
- doi: 10.4048/jbc.2018.21.e40
PURPOSE: Multidrug resistance (MDR) remains a major obstacle in the treatment of triple-negative breast cancer (TNBC) with conventional chemotherapeutic agents. A previous study demonstrated that hsa-miRNA-143-3p plays a vital role... -
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- Efficiency of Cytokine-Induced Killer Cells in Combination with Chemotherapy for Triple-Negative Breast Cancer
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Li M, Wang Y, Wei F, An X, Zhang N, Cao S, Ren B, Zhang X, Ren X
- KMID: 2413933
- J Breast Cancer.
- 2018 Jun;21(2):150-157.
- doi: 10.4048/jbc.2018.21.2.150
PURPOSE: The treatment of triple-negative breast cancer (TNBC) remains challenging, due to the absence of estrogen, progesterone, and human epidermal growth factor receptors. This study was designed to evaluate the... -
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- Lymphocyte-Activation Gene-3 Expression and Prognostic Value in Neoadjuvant-Treated Triple-Negative Breast Cancer
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Wang Y, Dong T, Xuan Q, Zhao H, Qin L, Zhang Q
- KMID: 2413930
- J Breast Cancer.
- 2018 Jun;21(2):124-133.
- doi: 10.4048/jbc.2018.21.2.124
PURPOSE: In this study, we aimed to evaluate lymphocyte-activation gene-3 (LAG-3) expression and its prognostic value in neoadjuvant-treated triple-negative breast cancer (TNBC). METHODS: LAG-3, programmed death-1 (PD-1), programmed death ligand-1 (PD-L1),... -
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- Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1
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Maharjan S, Park BK, Lee SI, Lim Y, Lee K, Kwon HJ
- KMID: 2421742
- Biomol Ther.
- 2018 May;26(3):322-327.
- doi: 10.4062/biomolther.2017.235
A type of breast cancer with a defect in three molecular markers such as the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor is called triple-negative breast cancer... -
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- Sonographic features that can be used to differentiate between small triple-negative breast cancer and fibroadenoma
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Yoon GY, Cha JH, Kim HH, Shin HJ, Chae EY, Choi WJ
- KMID: 2409566
- Ultrasonography.
- 2018 Apr;37(2):149-156.
- doi: 10.14366/usg.17036
PURPOSE: Our study investigated whether any sonographic findings could be useful for differentiating between small triple-negative breast cancer (TNBC) and fibroadenoma. METHODS: This retrospective study was approved by our Institutional Review... -
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- Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer
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Chung JM, Jung Y, Kim YP, Song J, Kim S, Kim JY, Kwon M, Yoon JH, Kim MD, Lee JK, Chung DY, Lee SY, Kang J, Kang HC
- KMID: 2441872
- J Breast Cancer.
- 2018 Mar;21(1):87-90.
- doi: 10.4048/jbc.2018.21.1.87
Triple-negative breast cancer (TNBC) has a higher risk of death within 5 years of being diagnosed than the other forms of breast cancer. It is the second leading cause of... -
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- Lymphovascular invasion as a negative prognostic factor for triple-negative breast cancer after surgery
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Ahn KJ, Park J, Choi Y
- KMID: 2401787
- Radiat Oncol J.
- 2017 Dec;35(4):332-339.
- doi: 10.3857/roj.2017.00416
PURPOSE: This study aimed to evaluate the prognostic effects of lymphovascular invasion (LVI) in triple-negative breast cancer (TNBC) patients who underwent surgical resection. MATERIALS AND METHODS: A total of 63 non-metastatic... -
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