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Issues on Long-term Management after Liver Transplantation in Children

Kim KM

With advancements of liver transplantation, the patient's survival improved remarkably. Thus the long-term survivors are increasing especially for the pediatric liver transplantation recipients. Consequently they are facing the challenge of...
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Prevention of Allograft Rejection by Immune Tolerance

Lee JS, Kwon B, Cho HR

  • KMID: 2003575
  • J Korean Soc Transplant.
  • 2006 Jun;20(1):1-13.
The development of immunosuprressants has had a significant contribution to inhibition of acute allograft rejection. However, long-term graft survival has not been realized by immunosuppressants, probably because of their nonspecific...
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Clinical Strategies to Develop Transplantation Tolerance

Lee JS, Kwon B, Cho HR

  • KMID: 1512743
  • Hanyang Med Rev.
  • 2006 Aug;26(3):70-76.
The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific...
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Induction of Donor-Specific Tolerance: Is This Achievable?

Cho EJ, Park JI, An JN, Kim YS

No abstract available.
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Allograft Immune Reaction of Kidney Transplantation: Part 1. Mechanism of Allograft Rejection

Kang HG

  • KMID: 2322082
  • J Korean Soc Pediatr Nephrol.
  • 2008 Apr;12(1):23-29.
Kidney allograft transplantation is the most effective method of renal replacement for end stage renal disease patients. Still, it is another kind of 'disease', requiring immunosuppression to keep the allograft...
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Comparative Analyses of Signature Genes in Acute Rejection and Operational Tolerance

Choi JW, Kim YH, Oh JW

Using biomarkers as prediction tools or therapeutic targets can be a valuable strategy in transplantation. Recent studies identified biomarkers of acute rejection (AR) and operational tolerance (TOL) through the application...
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Innate immunity and transplantation tolerance: the potential role of TLRs/NLRs in GVHD

Shin OS, Harris JB

Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic cell transplantation (HCT) and this occurs as donor T lymphocytes, activated by recipient antigen presenting cells (APC), attack the host...
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Association of Foxp3 Polymorphism With Allograft Outcome in Kidney Transplantation

Park H, Lee N, In JW, Roh EY, Park KU, Shin S, Yang J, Song EY

BACKGROUND: Forkhead box P3 (Foxp3) is the most reliable marker for regulatory T cells, which play an important role in maintaining renal allograft tolerance. Recently, Foxp3 polymorphisms have been reported...
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Donor Bone Marrow Infusion in Deceased and Living Donor Renal Transplantation

Ciancio G, Burke GW, Moon J, Morales RG, Rosen A, Esquenazi , Mathew J, Jin Y, Miller J

The infusion and persistence in a transplant recipient of donor-derived bone marrow cells (DBMC) of multi-lineage can lead to a state of permanent chimerism. In solid vascular organ transplantation, the...
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The Differential Effects of Donor-Strain Immature Dendritic Cell Subtypes and the Blockade of CD40/CD154 Pathway on the Creation of Allograft Tolerance

Yang SH, Seong EY, Lee JE, Shin JH, Zhe JJ, Sangidorj , Kim YS

  • KMID: 2254156
  • Korean J Nephrol.
  • 2006 Mar;25(2):195-204.
BACKGOUND: Dendritic cells (DC) are pivotal antigen presenting cells and serve a unique role in initiating immunity. To test the hypothesis that pre-immunization of recipient with certain DC subsets of...
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The Effects of Maturation Resistant Donor Dendritic Cells on Alloimmune Response in Mice

Lee JE, Kang HK, Seoung EY, Yang SH, Kim SJ, Shin SJ, Kim YS, Lee JS, Kim S

  • KMID: 2079489
  • Korean J Nephrol.
  • 2005 Jul;24(4):514-525.
BACKGROUND: Although dendritic cells (DCs) are the most influential antigen presenting cells maturation of DC is the critical control point toward either activation or regulation of immunity. We hypothesized that...
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Sirolimus Conversion Efficacy for Graft Function Improvement and Histopathology in Renal Recipients with Mild to Moderate Renal Insufficiency

Joo DJ, Yang CW, Jeong HJ, Lim BJ, Huh KH, Chung BH, Choi YJ, Kang SW, Kim YS

This study was designed to evaluate whether sirolimus (SRL) conversion effectively improves renal function and histopathology in calcineurin inhibitor (CNI)-treated renal recipients with mild to moderate renal insufficiency. SRL conversion...
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