Hanyang Med Rev.
2006 Aug;26(3):70-76.
Clinical Strategies to Develop Transplantation Tolerance
- Affiliations
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- 1Department of Internal Medicine, Ulsan University Hospital, College of Medicine, University of Ulsan, Korea.
- 2Department of Surgery, Ulsan University Hospital, College of Medicine, University of Ulsan, Korea. hrcho@uuh.ulsan.kr
- 3Department of Biological Science, University of Ulsan, Korea.
Abstract
- The development of immunosuprressants has had a significant influence on inhibition of acute allograft rejection. However, long-term graft survival has not been achieved by immunosuppressants, probably because of their nonspecific suppression of T cell activity and nonimmune side effects. The ideal way to overcome the limitations of current immunosuppressants is to induce allograft-specific immune tolerance. Transplant immunologists are exerting their efforts in achieving transplantation tolerance using four different approaches; costimulatory blockade, mixed hematopoietic chimerism, T cell depletion, and regulation by regulatory T cells. It is expected that transplantation tolerance will soon be established as a standard immunosuppressive regimen with little side effects in preventing and reversing allograft rejection.
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