- Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies
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Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S
- KMID: 2467417
- Asian Spine J.
- 2019 Dec;13(6):875-889.
- doi: 10.31616/asj.2019.0073
STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against... -
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- LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis
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Liu C, Ren S, Zhao S, Wang Y
- KMID: 2460226
- Yonsei Med J.
- 2019 Nov;60(11):1081-1092.
- doi: 10.3349/ymj.2019.60.11.1081
PURPOSE: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)... -
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- Differential Diagnosis and Treatment of Thrombotic Microangiopathy Syndrome
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Hong J
- KMID: 2438029
- Korean J Med.
- 2019 Feb;94(1):83-88.
- doi: 10.3904/kjm.2019.94.1.83
Diagnosis of thrombotic microangiopathy (TMA) is challenging due to its close association with other forms of microangiopathic hemolytic anemia, such as malignant hypertension and disseminated intravascular coagulation, and because other... -
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- Inhibition of the Expression of Matrix Metalloproteinases in Articular Chondrocytes by Resveratrol through Affecting Nuclear Factor-Kappa B Signaling Pathway
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Kang DG, Lee HJ, Lee CJ, Park JS
- KMID: 2427509
- Biomol Ther.
- 2018 Nov;26(6):560-567.
- doi: 10.4062/biomolther.2018.132
In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B (NF-κB) in articular chondrocytes. Rabbit articular chondrocytes were... -
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- Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth
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Yoo JY, You YA, Kwon EJ, Park MH, Shim S, Kim YJ
- KMID: 2426021
- Obstet Gynecol Sci.
- 2018 Sep;61(5):565-574.
- doi: 10.5468/ogs.2018.61.5.565
OBJECTIVE: This study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion. METHODS: We examined the association between differentially methylated regions (DMRs) and differentially expressed genes... -
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- Clinical characteristics and outcomes of thrombotic microangiopathy in Malaysia
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Yap YY, Sathar J, Law KB, Zulkurnain PAB, Edmund SC, Chang KM, Baker R
- KMID: 2451031
- Blood Res.
- 2018 Jun;53(2):130-137.
- doi: 10.5045/br.2018.53.2.130
BACKGROUND: Thrombotic microangiopathy (TMA) with non-deficient ADAMTS-13 (a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13) outcome is unknown hence the survival analysis correlating with ADAMTS-13 activity is conducted... -
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- In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin
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Kim TH, Yun YP, Shim KS, Kim HJ, Kim SE, Park K, Song HR
- KMID: 2411875
- Tissue Eng Regen Med.
- 2018 Jun;15(3):263-274.
- doi: 10.1007/s13770-018-0119-9
The aim of this study was to prepare inclusion nanocomplexes of hyaluronic acid-β-cyclodextrin and simvastatin (HA-β-CD/SIM) and evaluate in vitro anti-inflammation effects on lipopolysaccharide (LPS)-activated synoviocytes and chondrogenic differentiation effects... -
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- Effect of oleanolic acid on the activity, secretion and gene expression of matrix metalloproteinase-3 in articular chondrocytes in vitro and the production of matrix metalloproteinase-3 in vivo
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Kang DG, Lee HJ, Kim KT, Hwang SC, Lee CJ, Park JS
- KMID: 2371038
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):197-204.
- doi: 10.4196/kjpp.2017.21.2.197
In the present study, we tried to examine whether oleanolic acid regulates the activity, secretion and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well... -
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- Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat
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Ra HJ, Lee HJ, Jo HS, Nam DC, Lee YB, Kang BH, Moon DK, Kim DH, Lee CJ, Hwang SC
- KMID: 2371064
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):19-26.
- doi: 10.4196/kjpp.2017.21.1.19
We investigated whether betulin affects the gene expression, secretion and proteolytic activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3... -
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- Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo
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Nam DC, Kim BK, Lee HJ, Shin HD, Lee CJ, Hwang SC
- KMID: 2388679
- Korean J Physiol Pharmacol.
- 2016 Mar;20(2):221-228.
- doi: 10.4196/kjpp.2016.20.2.221
We investigated whether prunetin affects the proteolytic activity, secretion, and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3... -
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- Apigenin Regulates Interleukin-1β-Induced Production of Matrix Metalloproteinase Both in the Knee Joint of Rat and in Primary Cultured Articular Chondrocytes
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Park JS, Kim DK, Shin HD, Lee HJ, Jo HS, Jeong JH, Choi YL, Lee CJ, Hwang SC
- KMID: 2170528
- Biomol Ther.
- 2016 Mar;24(2):163-170.
- doi: 10.4062/biomolther.2015.217
We examined whether apigenin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in... -
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- Chondroprotective Effects of Wogonin in Experimental Models of Osteoarthritis in vitro and in vivo
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Park JS, Lee HJ, Lee DY, Jo HS, Jeong JH, Kim DH, Nam DC, Lee CJ, Hwang SC
- KMID: 2380293
- Biomol Ther.
- 2015 Sep;23(5):442-448.
- doi: 10.4062/biomolther.2015.045
We evaluated the chondroprotective effects of wogonin by investigating its effects on the gene expression and production of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as... -
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- A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation
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Choi JY, Lee JW, Ju HY, Hong CR, Kim H, Lee DS, Kim NH, Kang HJ, Park KD, Shin HY
- KMID: 2279824
- Clin Pediatr Hematol Oncol.
- 2014 Oct;21(2):140-144.
- doi: 10.0000/cpho.2014.21.2.140
Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report... -
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- Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure
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Pyun JA, Kim S, Kwack K
- KMID: 1805494
- Clin Exp Reprod Med.
- 2014 Sep;41(3):120-124.
- doi: 10.5653/cerm.2014.41.3.120
OBJECTIVE: The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated... -
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- Luteolin Inhibits the Activity, Secretion and Gene Expression of MMP-3 in Cultured Articular Chondrocytes and Production of MMP-3 in the Rat Knee
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Kang BJ, Ryu J, Lee CJ, Hwang SC
- KMID: 2170642
- Biomol Ther.
- 2014 May;22(3):239-245.
We investigated whether luteolin affects the gene expression, secretion and activity of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as production of MMP-3 in the rat... -
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- PPARgamma modulates vascular smooth muscle cell phenotype via a protein kinase G-dependent pathway and reduces neointimal hyperplasia after vascular injury
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Yang HM, Kim BK, Kim JY, Kwon YW, Jin S, Lee JE, Cho HJ, Lee HY, Kang HJ, Oh BH, Park YB, Kim HS
- KMID: 2154284
- Exp Mol Med.
- 2013 Nov;45(11):e65.
Vascular smooth muscle cells (VSMCs) undergo phenotypic changes in response to vascular injury such as angioplasty. Protein kinase G (PKG) has an important role in the process of VSMC phenotype... -
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- A Disintegrin and Metalloprotease with Thrombospondin Motif 2 May Contribute to Cirrhosis in Humans through the Transforming Growth Factor-beta/SMAD Pathway
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Dong C, Li HJ, Chang S, Liao HJ, Zhang ZP, Huang P, Tang HH
- KMID: 2135073
- Gut Liver.
- 2013 Mar;7(2):213-220.
BACKGROUND/AIMS: We aimed to investigate the correlation between a disintegrin and metalloprotease with thrombospondin motif 2 (ADAMTS-2) and transforming growth factor-beta1 (TGF-beta1) in clinical human cirrhotic tissues. METHODS: The liver tissues... -
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- Type 3 Repeats of Thrombospondin-2 Increases Metastasis in Mouse Colorectal Cancer CT-26 Cells
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Jin Z, Kim YJ, Park YK, Choi YD, Lee JH, Lee D, Choi CY, Juhng SW, Choi C
- KMID: 2172251
- Chonnam Med J.
- 2010 Apr;46(1):7-18.
- doi: 10.4068/cmj.2010.46.1.7
Thrombospondins (TSPs) are secreted multimeric glycoproteins that modulate extracellular matrix structure and cell behaviour. TSPs are involved in platelet aggregation, cell adhesion, migration, angiogenesis, wound healing, and proliferation. The purpose... -
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- Gene Expression in the Capsule Tissue of the Frozen Shoulder
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Kim JM, Kim YS, Ji JH, Lee JY, Yoo HH, Lee YK
- KMID: 2185596
- J Korean Orthop Assoc.
- 2010 Feb;45(1):65-72.
- doi: 10.4055/jkoa.2010.45.1.65
PURPOSE: To investigate the overall expression of extracellular matrix (ECM) and adhesion molecule genes using a gene array technique in the joint capsule of a frozen shoulder. MATERIALS AND METHODS: Tissues... -
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- Clinical Significance of von Willebrand Factor-Cleaving Protease (ADAMTS13) Deficiency in Patients with Sepsis-Induced Disseminated Intravascular Coagulation
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Kim YK, Lee J, Lee KA, Kwon HU
- KMID: 2170254
- Infect Chemother.
- 2009 Apr;41(2):78-81.
- doi: 10.3947/ic.2009.41.2.78
BACKGROUND: Deficiency of von Willebrand factor-cleaving protease, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13), is thought to be responsible for platelet aggregation and microthrombi formation, which... -
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