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The effect of alpha-lipoic acid on expression of VCAM-1 in type 2 diabetic rat

Ismawati , Mukhyarjon , Asni E, Romus I

Macrovascular diabetes complications are generally caused by a process called atherosclerosis. Evidences suggest that to initiate atherosclerosis, oxidated low-density lipoprotein (oxLDL) has to promote the expression of adhesion molecule. Several...
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Anti-Inflammatory and Antioxidative Effects of Alpha Lipoic Acid on Cultured Human Sebocytes

Lee WJ, Eun DH, Kim SM, Kim JY, Jang YH, Lee SJ

No abstract available.
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Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease

Lee SB, Lee MY, You JH, Kim SH, Nam JS

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia, extremely high serum insulin levels, and high titers of autoantibodies against endogenous insulin, in the absence of exogenous insulin injection. IAS...
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Comparison of R(+)-α-lipoic acid exposure after R(+)-α-lipoic acid 200 mg and 300 mg and thioctic acid 600 mg in healthy Korean male subjects

Yoon J, Moon SJ, Lee KO, Yoon SH, Jang IJ, Yu KS, Lee S

Alpha-lipoic acid, a physiological form of thioctic acid, is a strong antioxidant that relieves diabetic neuropathic symptoms. R(+)-α-lipoic acid shows superior antioxidative effects to its racemate. We compared the pharmacokinetics...
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Recurrent Insulin Autoimmune Syndrome Caused by alpha-Lipoic Acid in Type 2 Diabetes

Bae SM, Bae MN, Kim EY, Kim IK, Seo MW, Shin JK, Cho SR, Jeong GH

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the...
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Suppression of VEGF and STAT3 by Lipoic acid in Experimental Diabetic Rat Retina

Yu SI, Jung HJ, Her DY, Kim HW, Yun IH

  • KMID: 2210949
  • J Korean Ophthalmol Soc.
  • 2007 May;48(5):715-724.
PURPOSE: We evaluated whether lipoic acid as antioxidant could inhibit expression of VEGF and STAT3 in experimental diabetic rat retina. METHODS: Diabetes was induced chemically by injection of streptozotocin in...
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The Effect of Alpha-lipoic Acid on the Cell Cycle Arrest and Apoptosis in Rat Vascular Smooth Muscle Cells

Kim HJ, Lee IK, Kim YH, Shin SY, Lee YH, Kim JG, Kim BW, Kim HS, Kim MK, Park KG, Ryu SY

BACKGROUND: The proliferation of vascular smooth muscle cells (VSMCs) is a hallmark of atheroscelrosis and post-angioplasty restenosis. We previously showed that alpha-lipoic acid (ALA) inhibited neointimal hyperplasia and has potential...
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Effects of alpha-Lipoic Acid on Apoptotic Cell Death in Rat Hippocampus Following Transient Forebrain Ischemia-reperfusion Injury

Ahn HC, Song JH, Kim KS, Yoo SJ

  • KMID: 2331506
  • J Korean Soc Emerg Med.
  • 2007 Apr;18(2):134-142.
PURPOSE: The purpose of this study was to evaluate effect of alpha-lipoic acid on apoptotic cell death in rat hippocampal neuron following transient forebrain ischemia-reperfusion (I/R) injury. METHODS: The four-vessel occlusion...
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Effects of Alpha-lipoic Acid on Nitric Oxide Synthase Expression and Ultrastructural Changes in the Bladder of Rats with Streptozotocin-induced Diabetes

Kang DI, Kim SH, Lee SD, Kwak HS, Choi SH, Kim DR, Min KS

PURPOSE: To evaluate whether alpha-lipoic acid (ALA) is effective at restoring the levels of nitric oxide synthase (NOS) expression and preventing ultrastructural changes in the bladder of rats with streptozotocin-...
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The Efficacy of alpha-lipoic Acid on the Endotoxin-induced Acute Lung Injury

Huh JW, Hong SB, Kim MJ, Lim CM, Koh Y

BACKGROUND: Oxidative stress may play an important role in the pathogenesis of endotoxin-induced acute lung injury (ALI). This study evaluated the therapeutic effect of alpha-lipoic acid, a nonenzymatic antioxidant, in...
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The Effect of Alpha-Lipoic Acid on the Protection of Epidermal Nerve Fibers and Microcapillaries in the Streptozotocin-Induced Diabetic Rats

Piao MH, Jin HY, Song SK, Kang SM, Kim SY, Park JH, Baek HS, Park TS

BACKGROUND: Diabetic neuropathy is associated with risk factors for macrovascular diseases and other microvascular complications. Alpha-lipoic acid (ALA) administration has been reported to improve metabolic abnormalities and ameliorate peripheral polyneuropathy...
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The Effect of Oral Administration of Alpha Lipoic Acid and Alpha Lipoic Acid Coated Stent in Porcine In-Stent Restenosis Model

Lim SY, Bae EH, Jeong MH, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC, Cho DL, Kim KS, Joo SJ

BACKGROUND AND OBJECTIVES: Alpha lipoic acid (ALA) is beneficial for improving endothelial dysfunction and preventing atherosclerosis-related diseases. We evaluated the affect of ALA on stent restenosis in a porcine model. MATERIALS...
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The Effects of Alpha-Lipoic Acid on Epidermal Nerve Preservation in the Diabetic Neuropathy of OLETF Rats

Piao MH, Park JH, Baek HS, Park TS

BACKGROUND: Alpha-Lipoic acid (ALA) administration has been reported to ameliorate some of symptoms of peripheral polyneuropathy in diabetic patients and to improve endoneurial nutritive neural blood flow and nerve conduction...
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The Comparison of Efficacy with alpha-lipoic Acid Treatment Methods in Diabetic Polyneuropathy

Lee H, Min KW, Han KA

BACKGROUND: Diabetic neuropathy represents a major health problem, as it is responsible for substantial morbidity, increased mortality, and impaired quality of life. Antioxidant treatment has been shown to prevent nerve...
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Alpha-Lipoic acid Inhibits TNF-alpha-Induced Fractalkine Expression in Rat aortic Smooth Muscle Cells

Park KG, Kim HS, Ryu SY, Nam CW, Chae BK, Jung ED, Kim JG, Kim BW, Lee IK

  • KMID: 2008233
  • J Korean Diabetes Assoc.
  • 2005 Sep;29(5):409-417.
BACKGOUND: The induction of vascular inflammation via the proinflammatory cytokine/ nuclear factor (NF)-kappaB pathway is one of the key mechanisms in the development and progression of atherosclerosis. Accumulating evidence suggests...
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Effect of 12-week Oral Treatment with alpha-lipoic acid on the Nerve Conduction in Symptomatic Diabetic Neuropathy

Sohn TS, Lee JM, Chang SA, Son HS, Cha BY, Son HY, Lee KW, Kang SK

  • KMID: 2177741
  • J Korean Diabetes Assoc.
  • 2005 Nov;29(6):533-539.
BACKGROUND: Diabetic peripheral neuropathy is multifactorial disorder arising from hyperglycemia and insulin deficiency. It has been suggested that oxidative stress resulting from enhanced free-radical formation and defects in antioxidant defence...
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Effects of alpha-Lipoic Acid on Bone Metabolism in Rats with Low Bone Mass

Koh JM, Lee HS, Kim DJ, Kim GS

BACKGROUND: Growing evidence has shown a biochemical link between increased oxidative stress and reduced bone density. In our previous study, alpha-lipoic acid (alpha-LA), a thiol antioxidant, suppressed both osteoclastogenesis and...
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Neurotrophic Effect of alpha-Lipoic Acid on Diabetic Neuropathy

Lee WT, Ha HJ, Ahn SK, Lee JE, Park KA

  • KMID: 2092855
  • Korean J Anat.
  • 2005 Oct;38(5):379-383.
The metabolic antioxidant alpha-lipoate has been shown to be potent antioxidants to regenerate through redox cycling other antioxidants and to raise intracelluar glutathione levels. The peripheral nerve of experimental diabetic...
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Improvement of Metabolic Syndrom by Alpha-lipoic Acid

Koh EH, Lee WJ, Kim MS, Park JY, Lee KU

  • KMID: 1515269
  • J Korean Soc Endocrinol.
  • 2004 Jun;19(3):267-273.
No abstract available.
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Effect of Peroxisome Proliferator Activated Receptor-gamma Agonist, Angiotensin II Receptor Blocker and alpha-lipoic Acid on Renal VEGF Expression in Diabetic Nephropathy

Koh JH, Lee Y, Kim MJ, Shin YG, Lee EY, Chung CH

  • KMID: 2008165
  • J Korean Diabetes Assoc.
  • 2004 Oct;28(5):367-376.
BACKGROUND: Diabetic nephropathy is one of the most serious complications in diabetes mellitus, and it is the leading cause of end stage renal disease. It has been reported that angiotensin...
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