- Lyso-globotriaosylsphingosine induces endothelial dysfunction via autophagy-dependent regulation of necroptosis
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Hwang AR, Park S, Woo CH
- KMID: 2541635
- Korean J Physiol Pharmacol.
- 2023 May;27(3):231-240.
- doi: 10.4196/kjpp.2023.27.3.231
Fabry disease is a lysosomal storage disorder characterized by the lysosomal accumulations of glycosphingolipids in a variety of cytotypes, which include endothelial cells. The disease is inherited and originates from... -
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- MST1R as a potential new target antigen of chimeric antigen receptor T cells to treat solid tumors
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An W, Kang JS, Oh S, Tu A
- KMID: 2541636
- Korean J Physiol Pharmacol.
- 2023 May;27(3):241-256.
- doi: 10.4196/kjpp.2023.27.3.241
Although chimeric antigen receptor T cell (CAR-T) is a promising immunotherapy in hematological malignancies, there remain many obstacles to CART cell therapy for solid tumors. Identifying appropriate tumor-associated antigens (TAAs)... -
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- Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression
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Zheng W, Li T, Wei J, Yan Y, Yang S
- KMID: 2541633
- Korean J Physiol Pharmacol.
- 2023 May;27(3):209-220.
- doi: 10.4196/kjpp.2023.27.3.209
This study is to determine the regulation of nitric oxide synthase 3 (NOS3) by edaravone in mice with hypoxic pulmonary hypertension (HPH). C57BL/6J mice were reared in a hypoxic chamber.... -
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- Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice
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Zhu Q, Zhou Q, Luo Xl, Zhang Xj, Li Sy
- KMID: 2541634
- Korean J Physiol Pharmacol.
- 2023 May;27(3):221-230.
- doi: 10.4196/kjpp.2023.27.3.221
Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these... -
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- New in vitro multiple cardiac ion channel screening system for preclinical Torsades de Pointes risk prediction under the Comprehensive in vitro Proarrhythmia Assay concepta
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An JR, Mun SY, Jung IK, Kim KS, Kwon CH, Choi SO, Park WS
- KMID: 2541638
- Korean J Physiol Pharmacol.
- 2023 May;27(3):267-275.
- doi: 10.4196/kjpp.2023.27.3.267
Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive... -
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- Saturated fatty acid-inducible miR-103-3p impairs the myogenic differentiation of progenitor cells by enhancing cell proliferation through Twinfilin-1/F-actin/YAP1 axis
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Nguyen MT, Lee W
- KMID: 2541639
- Korean J Physiol Pharmacol.
- 2023 May;27(3):277-287.
- doi: 10.4196/kjpp.2023.27.3.277
Actin dynamics play an essential role in myogenesis through multiple mechanisms, such as mechanotransduction, cell proliferation, and myogenic differentiation. Twinfilin-1 (TWF1), an actin-depolymerizing protein, is known to be required for... -
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- LINC00562 drives gastric cancer development by regulating miR-4636–AP1S3 axis
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Xu L, Liu D, Wang X
- KMID: 2541632
- Korean J Physiol Pharmacol.
- 2023 May;27(3):197-208.
- doi: 10.4196/kjpp.2023.27.3.197
Dysregulation of certain long non-coding RNAs may facilitate tumor initiation and progression. However, numerous carcinogenesis-related long non-coding RNAs have not been characterized. The goal of this study was to elucidate... -
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- Rac1 inhibition protects the kidney against kidney ischemia/ reperfusion through the inhibition of macrophage migration
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Park YR, Kong MJ, Noh MR, Park KM
- KMID: 2541637
- Korean J Physiol Pharmacol.
- 2023 May;27(3):257-265.
- doi: 10.4196/kjpp.2023.27.3.257
Kidney ischemia/reperfusion (I/R) injury, a common cause of acute kidney injury (AKI), is associated with the migration of inflammatory cells into the kidney. Ras-related C3 botulinum toxin substrate 1 (Rac1),... -
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