- 27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms
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Kim BY, Son Y, Cho Hr, Lee D, Eo SK, Kim K
- KMID: 2512954
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):111-118.
- doi: 10.4196/kjpp.2021.25.2.111
27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on... -
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- Far-infrared rays enhance mitochondrial biogenesis and GLUT3 expression under low glucose conditions in rat skeletal muscle cells
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Seo Y, Kim YW, Lee D, Kim D, Kim K, Kim T, Baek C, Lee Y, Lee J, Lee H, Jang G, Jeong W, Choi J, Hwang D, Suh JS, Kim SW, Kim HK, Han J, Bang H, Kim JH, Zhou T, Ko JH
- KMID: 2512960
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):167-175.
- doi: 10.4196/kjpp.2021.25.2.167
Far-infrared rays (FIR) are known to have various effects on atoms and molecular structures within cells owing to their radiation and vibration frequencies. The present study examined the effects of... -
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- IDH2 gene deficiency accelerates unilateral ureteral obstructioninduced kidney inflammation through oxidative stress and activation of macrophages
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Kim JI, Noh MR, Yoon GE, Jang HS, Kong MJ, Park KM
- KMID: 2512957
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):139-146.
- doi: 10.4196/kjpp.2021.25.2.139
Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the... -
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- NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria
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Wu Cz, Li X, Hong L, Han Zn, Liu Y, Wei Cx, Cui X
- KMID: 2512959
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):159-166.
- doi: 10.4196/kjpp.2021.25.2.159
Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are the major enzymatic source of reactive oxygen species (ROS). NOX2 and NOX4 are expressed in the heart but its role in hypoxia-induced atrial... -
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- Centromere protein U enhances the progression of bladder cancer by promoting mitochondrial ribosomal protein s28 expression
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Liu BB, Ma T, Sun W, Gao WY, Liu JM, Li LQ, Li WY, Wang S, Guo YY
- KMID: 2512955
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):119-129.
- doi: 10.4196/kjpp.2021.25.2.119
Bladder cancer is one of the most common types of cancer. Most gene mutations related to bladder cancer are dominantly acquired gene mutations and are not inherited. Previous comparative transcriptome... -
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- Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway
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Cheng J, Ren C, Cheng R, Li Y, Liu P, Wang W, Liu L
- KMID: 2512956
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):131-137.
- doi: 10.4196/kjpp.2021.25.2.131
Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a wellknown C-glucoside xanthone in mango leaves with lots of... -
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- Paeoniflorin treatment regulates TLR4/NF-κB signaling, reduces cerebral oxidative stress and improves white matter integrity in neonatal hypoxic brain injury
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Yang F, Li Y, Sheng X, Liu Y
- KMID: 2512953
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):97-109.
- doi: 10.4196/kjpp.2021.25.2.97
Neonatal hypoxia/ischemia (H/I), injures white matter, results in neuronal loss, disturbs myelin formation, and neural network development. Neuroinflammation and oxidative stress have been reported in neonatal hypoxic brain injuries. We... -
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- Puerarin pretreatment attenuates cardiomyocyte apoptosis induced by coronary microembolization in rats by activating the PI3K/Akt/GSK-3β signaling pathway
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Chen ZQ, Zhou Y, Huang JW, Chen F, Zheng J, Li HL, Li T, Li L
- KMID: 2512958
- Korean J Physiol Pharmacol.
- 2021 Mar;25(2):147-157.
- doi: 10.4196/kjpp.2021.25.2.147
Coronary microembolization (CME) is associated with cardiomyocyte apoptosis and cardiac dysfunction. Puerarin confers protection against multiple cardiovascular diseases, but its effects and specific mechanisms on CME are not fully known.... -
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