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Effects of hydrogen peroxide on voltage-dependent K+ currents in human cardiac fibroblasts through protein kinase pathways

Bae H, Lee D, Kim YW, Choi J, Lee HJ, Kim SW, Kim T, Noh YH, Ko JH, Bang H, Lim I

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):315-324.
  • doi: 10.4196/kjpp.2016.20.3.315
Human cardiac fibroblasts (HCFs) have various voltage-dependent K+ channels (VDKCs) that can induce apoptosis. Hydrogen peroxide (H2O2) modulates VDKCs and induces oxidative stress, which is the main contributor to cardiac...
NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts

Thu VT, Kim HK, Long LT, Thuy TT, Huy NQ, Kim SH, Kim N, Ko KS, Rhee BD, Han J

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):305-314.
  • doi: 10.4196/kjpp.2016.20.3.305
Inflammatory and fibrotic responses are accelerated during the reperfusion period, and excessive fibrosis and inflammation contribute to cardiac malfunction. NecroX compounds have been shown to protect the liver and heart...
Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome

Kim JH, Hwang KH, Lkhagvadorj S, Jung JH, Chung HC, Park KS, Kong ID, Eom M, Cha SK

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):297-304.
  • doi: 10.4196/kjpp.2016.20.3.297
Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have...
Voluntary stand-up physical activity enhances endurance exercise capacity in rats

Seo DY, Lee SR, Kwak HB, Seo KW, McGregor R, Yeo JY, Ko TH, Bolorerdene S, Kim N, Ko KS, Rhee BD, Han J

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):287-295.
  • doi: 10.4196/kjpp.2016.20.3.287
Involuntary physical activity induced by the avoidance of electrical shock leads to improved endurance exercise capacity in animals. However, it remains unknown whether voluntary stand-up physical activity (SPA) without forced...
Neuroprotective effect of caffeic acid phenethyl ester in 3-nitropropionic acid-induced striatal neurotoxicity

Bak J, Kim HJ, Kim SY, Choi YS

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):279-286.
  • doi: 10.4196/kjpp.2016.20.3.279
Caffeic acid phenethyl ester (CAPE), derived from honeybee hives, is a bioactive compound with strong antioxidant activity. This study was designed to test the neuroprotective effect of CAPE in 3-nitropropionic...
Ellagic acid plays a protective role against UV-B-induced oxidative stress by up-regulating antioxidant components in human dermal fibroblasts

Baek B, Lee SH, Kim K, Lim HW, Lim CJ

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):269-277.
  • doi: 10.4196/kjpp.2016.20.3.269
Ellagic acid (EA), an antioxidant polyphenolic constituent of plant origin, has been reported to possess diverse pharmacological properties, including anti-inflammatory, anti-tumor and immunomodulatory activities. This work aimed to clarify the...
Immunotherapy with methyl gallate, an inhibitor of Treg cell migration, enhances the anti-cancer effect of cisplatin therapy

Kim H, Lee G, Sohn SH, Lee C, Kwak JW, Bae H

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):261-268.
  • doi: 10.4196/kjpp.2016.20.3.261
Foxp3+ CD25+CD4+ regulatory T (Treg) cells are crucial for the maintenance of immunological self-tolerance and are abundant in tumors. Most of these cells are chemo-attracted to tumor tissues and suppress...
4-(Tert-butyl)-2,6-bis(1-phenylethyl)phenol induces pro-apoptotic activity

Kim JH, Lee Y, Kim MY, Cho JY

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):253-259.
  • doi: 10.4196/kjpp.2016.20.3.253
Previously, we found that KTH-13 isolated from the butanol fraction of Cordyceps bassiana (Cb-BF) displayed anti-cancer activity. To improve its antiproliferative activity and production yield, we employed a total synthetic...
Prospective validation of a novel dosing scheme for intravenous busulfan in adult patients undergoing hematopoietic stem cell transplantation

Cho SH, Lee JH, Lim HS, Lee KH, Kim DY, Choe S, Bae KS, Lee JH

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):245-251.
  • doi: 10.4196/kjpp.2016.20.3.245
The objective of this study was to externally validate a new dosing scheme for busulfan. Thirty-seven adult patients who received busulfan as conditioning therapy for hematopoietic stem cell transplantation (HCT)...
Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mTOR and ROS-dependent pathway

Shi Y, Song Q, Hu D, Zhuang X, Yu S, Teng D

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):237-243.
  • doi: 10.4196/kjpp.2016.20.3.237
Oleanolic acid (OA) has a wide variety of bioactivities such as hepatoprotective, anti-inflammatory and anti-cancer activity and is used for medicinal purposes in many Asian countries. In the present study,...
Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells

Bae EH, Joo SY, Ma SK, Lee J, Kim SW

  • Korean J Physiol Pharmacol.
  • 2016 May;20(3):229-236.
  • doi: 10.4196/kjpp.2016.20.3.229
Resveratrol (RSV) may provide numerous protective eff ects against chronic inflammatory diseases. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress, and aldehyde products...

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