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Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association

Park PW, Ahn JY, Yang D

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):433-440.
  • doi: 10.4196/kjpp.2016.20.4.433
Inositol-1,4,5-triphosphate [IP3] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly...
Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells

Pai YH, Lim CS, Park KA, Cho HS, Lee GS, Shin YS, Kim HW, Jeon BH, Yoon SH, Park JB

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):425-432.
  • doi: 10.4196/kjpp.2016.20.4.425
In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the...
Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages

Bae YA, Cheon HG

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):415-424.
  • doi: 10.4196/kjpp.2016.20.4.415
Berberine is an isoquinoline alkaloid found in Rhizoma coptidis, and elicits anti-inflammatory effects through diverse mechanisms. Based on previous reports that activating transcription factor-3 (ATF-3) acts as a negative regulator...
Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain

Lee JH, Go D, Kim W, Lee G, Bae H, Quan FS, Kim SK

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):407-414.
  • doi: 10.4196/kjpp.2016.20.4.407
This study was performed to investigate whether the spinal cholinergic and serotonergic analgesic systems mediate the relieving effect of electroacupuncture (EA) on oxaliplatin-induced neuropathic cold allodynia in rats. The cold...
Preventive effects of imperatorin on perfluorohexanesulfonate-induced neuronal apoptosis via inhibition of intracellular calcium-mediated ERK pathway

Lee E, Choi SY, Yang JH, Lee YJ

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):399-406.
  • doi: 10.4196/kjpp.2016.20.4.399
Early life neuronal exposure to environmental toxicants has been suggested to be an important etiology of neurodegenerative disease development. Perfluorohexanesulfonate (PFHxS), one of the major perfluoroalkyl compounds, is widely distributed...
Sequestration of sorcin by aberrant forms of tau results in the defective calcium homeostasis

Kim SI, Lee HJ, Kim SS, Kwon YS, Chun W

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):387-397.
  • doi: 10.4196/kjpp.2016.20.4.387
Neurofi brillary tangles (NFTs) of microtubule-associated protein tau are a pathological hallmark of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress has been known to be involved in the pathogenesis of...
Effects of analgesics and antidepressants on TREK-2 and TRESK currents

Park H, Kim EJ, Han J, Han J, Kang D

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):379-385.
  • doi: 10.4196/kjpp.2016.20.4.379
TWIK-related K+ channel-2 (TREK-2) and TWIK-related spinal cord K+ (TRESK) channel are members of two-pore domain K+ channel family. They are well expressed and help to set the resting membrane...
Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin

Hong JY, Hara K, Kim JW, Sato EF, Shim EB, Cho KH

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):367-378.
  • doi: 10.4196/kjpp.2016.20.4.367
Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a...
Effects of systemic administration of ibuprofen on stress response in a rat model of post-traumatic stress disorder

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):357-366.
  • doi: 10.4196/kjpp.2016.20.4.357
Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of...
Cryptotanshinone inhibits TNF-α-induced LOX-1 expression by suppressing reactive oxygen species (ROS) formation in endothelial cells

Ran X, Zhao W, Li W, Shi J, Chen X

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):347-355.
  • doi: 10.4196/kjpp.2016.20.4.347
Cryptotanshinone (CPT) is a natural compound isolated from traditional Chinese medicine Salvia miltiorrhiza Bunge. In the present study, the regulatory effect and potential mechanisms of CPT on tumor necrosis factor...
The effect of progesterone and 17-β estradiol on membrane-bound HLA-G in adipose derived stem cells

Moslehi A, Hashemi-beni B, Moslehi A, Akbari MA, Adib M

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):341-346.
  • doi: 10.4196/kjpp.2016.20.4.341
Membrane-bound HLA-G (mHLA-G) discovery on adipose derived stem cells (ADSCs) as a tolerogenic and immunosuppressive molecule was very important. Many documents have shown that HLA-G expression can be controlled via...
Effect of edaravone in diabetes mellitus-induced nephropathy in rats

Varatharajan R, Lim LX, Tan K, Tay CS, Teoh YL, Akhtar SS, Rupeshkumar M, Chung I, Abdullah N, Banik U, Dhanaraj S, Balakumar

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):333-340.
  • doi: 10.4196/kjpp.2016.20.4.333
Edaravone, a synthetic-free radical scavenger, has been reported to reduce ischemia-reperfusion-induced renal injury by improving tubular cell function, and lowering serum creatinine and renal vascular resistance. The present study investigated...
Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation

Hu M, Liu B

  • Korean J Physiol Pharmacol.
  • 2016 Jul;20(4):325-332.
  • doi: 10.4196/kjpp.2016.20.4.325
Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions,...

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