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17 results

Polyphenols of Rubus coreanum Inhibit Catecholamine Secretion from the Perfused Adrenal Medulla of SHRs

Yu BS, Na DM, Kang MY, Lim DY

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):517-526.
  • doi: 10.4196/kjpp.2009.13.6.517
The present study was attempted to investigate whether polyphenolic compounds isolated from wine, which is brewed from Rubus coreanum Miquel (PCRC), may affect the release of catecholamines (CA) from the...
Cytotoxic Activity and Three-Dimensional Quantitative Structure Activity Relationship of 2-Aryl-1,8-naphthyridin-4-ones

Kim YJ, Kim EA, Chung ML, Im C

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):511-516.
  • doi: 10.4196/kjpp.2009.13.6.511
A series of substituted 2-arylnaphthyridin-4-one analogues, which were previously synthesized in our laboratory, were evaluated for their in vitro cytotoxic activity against human lung cancer A549 and human renal cancer...
Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents

Kim YC, Choi W, Sung R, Kim H, You RY, Park SM, Youn SJ, Kim MJ, Song YJ, Xu WX, Lee SJ, Yun HY

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):503-510.
  • doi: 10.4196/kjpp.2009.13.6.503
To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5' -cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects...
Efficient Management Design for Swimming Exercise Treatment

Kim K, Kyung T, Kim W, Shin C, Song Y, Lee MY, Lee H, Cho Y

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):497-502.
  • doi: 10.4196/kjpp.2009.13.6.497
Exercise-mediated physical treatment has attracted much recent interest. In particular, swimming is a representative exercise treatment method recommended for patients experiencing muscular and cardiovascular diseases. The present study sought to...
p38 MAPK Participates in Muscle-Specific RING Finger 1-Mediated Atrophy in Cast-Immobilized Rat Gastrocnemius Muscle

Kim J, Won KJ, Lee HM, Hwang BY, Bae YM, Choi WS, Song H, Lim KW, Lee CK, Kim B

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):491-496.
  • doi: 10.4196/kjpp.2009.13.6.491
Skeletal muscle atrophy is a common phenomenon during the prolonged muscle disuse caused by cast immobilization, extended aging states, bed rest, space flight, or other factors. However, the cellular mechanisms...
Knockdown of RCAN1.4 Increases Susceptibility to FAS-mediated and DNA-damage-induced Apoptosis by Upregulation of p53 Expression

Kim YS, Lee HJ, Jang C, Kim HS, Cho YJ

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):483-489.
  • doi: 10.4196/kjpp.2009.13.6.483
Despite the potential importance of the human regulator of calcineurin 1 (RCAN-1) gene in the modulation of cell survival under stress, little is known about its role in death-inducing signal...
Rifampicin Inhibits the LPS-induced Expression of Toll-like Receptor 2 via the Suppression of NF-kappaB DNA-binding Activity in RAW 264.7 Cells

Kim SK, Kim YM, Yeum CE, Jin SH, Chae GT, Lee SB

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):475-482.
  • doi: 10.4196/kjpp.2009.13.6.475
Rifampicin is a macrocyclic antibiotic which is used extensively for treatment against Mycobacterium tuberculosis and other mycobacterial infections. Recently, a number of studies have focused on the immune-regulatory effects of...
Intraocular Injection of Muscimol Induces Illusory Motion Reversal in Goldfish

Lee SY, Jung CS

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):469-473.
  • doi: 10.4196/kjpp.2009.13.6.469
Induced activation of the gamma-aminobutyric acidA (GABA(A)) receptor in the retina of goldfish caused the fish to rotate in the opposite direction to that of the spinning pattern during an...
Nitric Oxide Modulation of GABAergic Synaptic Transmission in Mechanically Isolated Rat Auditory Cortical Neurons

Lee JJ

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):461-467.
  • doi: 10.4196/kjpp.2009.13.6.461
The auditory cortex (A1) encodes the acquired significance of sound for the perception and interpretation of sound. Nitric oxide (NO) is a gas molecule with free radical properties that functions...
Type II and III Taste Bud Cells Preferentially Expressed Kainate Glutamate Receptors in Rats

Lee SB, Lee CH, Kim SN, Chung KM, Cho YK, Kim KN

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):455-460.
  • doi: 10.4196/kjpp.2009.13.6.455
Glutamate-induced cobalt uptake reveals that non-NMDA glutamate receptors (GluRs) are present in rat taste bud cells. Previous studies involving glutamate induced cobalt staining suggest this uptake mainly occurs via kainate...
Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats

Seo E, Park EJ, Joe Y, Kang S, Kim MS, Hong SH, Park MK, Kim DK, Koh H, Lee HJ

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):449-454.
  • doi: 10.4196/kjpp.2009.13.6.449
5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (alpha) and two regulatory (beta and gamma) subunits. Two isoforms are known for catalytic subunit (alpha1, alpha2) and...
Electrically-evoked Neural Activities of rd1 Mice Retinal Ganglion Cells by Repetitive Pulse Stimulation

Ryu SB, Ye JH, Lee JS, Goo YS, Kim CH, Kim KH

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):443-448.
  • doi: 10.4196/kjpp.2009.13.6.443
For successful visual perception by visual prosthesis using electrical stimulation, it is essential to develop an effective stimulation strategy based on understanding of retinal ganglion cell (RGC) responses to electrical...
Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca2+ Channels in Neonatal Rat Ventricular Cardiomyocytes

Yarishkin , Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):437-442.
  • doi: 10.4196/kjpp.2009.13.6.437
A non-steroidal anti-inflammatory drug (NSAID) has many adverse effects including cardiovascular (CV) risk. Diclofenac among the nonselective NSAIDs has the highest CV risk such as congestive heart failure, which resulted...
Overexpression of Ref-1 Inhibits Lead-induced Endothelial Cell Death via the Upregulation of Catalase

Lee KH, Lee SK, Kim HS, Cho EJ, Joo HK, Lee EJ, Lee JY, Park MS, Chang SJ, Cho CH, Park JB, Jeon BH

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):431-436.
  • doi: 10.4196/kjpp.2009.13.6.431
The role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the lead (Pb)-induced cellular response was investigated in the cultured endothelial cells. Pb caused progressive cellular death in endothelial cells, which occurred...
The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats

Kwon YB, Jeong YC, Kwon JK, Son JS, Kim KW

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):425-429.
  • doi: 10.4196/kjpp.2009.13.6.425
Intracranial headaches, including migraines, are mediated by nociceptive activation of the trigeminal nucleus caudalis (TNC), but the precise mechanisms are poorly understood. We previously demonstrated that selective blockage of spinal...
Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells

Park YR, Eun JS, Choi HJ, Nepal M, Kim DK, Seo SY, Li R, Moon WS, Cho NP, Cho SD, Bae TS, Kim BI, Soh Y

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):417-424.
  • doi: 10.4196/kjpp.2009.13.6.417
Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast...
Altered Gene Expression in Cerulein-Stimulated Pancreatic Acinar Cells: Pathologic Mechanism of Acute Pancreatitis

Yu JH, Lim JW, Kim H

  • Korean J Physiol Pharmacol.
  • 2009 Dec;13(6):409-416.
  • doi: 10.4196/kjpp.2009.13.6.409
Acute pancreatitis is a multifactorial disease associated with the premature activation of digestive enzymes. The genes expressed in pancreatic acinar cells determine the severity of the disease. The present study...

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