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The effect of rebamipide on cellular release of leukotriene B4 by Helicobacter pylori

Lee JJ, Han BG, Ro JY, Rhee KH, Youn HS, Kim MN, Chung MH

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):825-830.
Leukotrienes (LTs) are known to act as a mediator provoking tissue response in inflammation. This finding implicates that LTs also play important roles in the pathogenesis of H. pylori-induced gastritis and gastric ulceration....
Apoptosis induced by adenosine 5'-trisphosphate in mouse leukemic cells

Joo NY, Park KS, Chung HS, Lee JW

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):817-824.
Extracellular ATP elicits various biological responses and plays a significant role in physiological regulation. Recently, ATP-induced growth inhibitions were reported in some tumor cell lines, but these effects and mechanisms are not well...
Role of endogenous nitric oxide in the control salivary secretion and blood flow

Kim W, Nam SC, Kim M

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):809-816.
The present study was designed to investigate whether endogenous nitric oxide (EDNO) is involved in submandibular vasodilation and salivation induced by parasympathetic nerve stimulation. Effects of Nw-nitro-L-arginine-methyl ester (L-NAME) which blocks the synthesis...
The effect of sodium nitroprusside on muscle tension in guinea-pig ileum

Kwon SC, Kim SY, Kim EJ, Kang BS

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):797-808.
Nitric oxide (NO) has been known as a mediator of nonadrenergic, noncholinergic inhibitory neurotransmitter in intestinal smooth muscles. It has been suggested that NO donor such as sodium nitroprusside (SNP) produces relaxation of...
Action mechanisms of NANC neurotransmitters in smooth muscle of guinea pig ileum

Lee YH, Kim JH, Kang BS

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):783-796.
The relaxation induced by stimulation of the inhibitory non-adrenergic, non-cholinergic (iNANC) nerve is mediated by the release of iNANC neurotransmitters such as nitric oxide (NO), vasoactive intestinal peptide (VIP) and adenosine triphosphate (ATP)....
Determinant role of the severity of hypoxia in the induction of reoxygenation injury in cat lung

Nam HJ, Kim YK, Na HS, Hong SK

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):775-781.
Although reoxygenation is the best way to salvage hypoxic tissues, reduced oxygen species (ROS) generated during reoxygenation are known to cause further tissue injuries and the induction of heat shock proteins (HSPs). The...
Involvement of peripheral benzodiazepine receptor on contractility of canine trachealis muscle

Rhyu HY, Choi HC, Choi EM, Sohn UD, Lee KY, Kim WJ, Ha JH

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):769-774.
Non-neuronal high affinity binding sites for benzodiazepines have been found in many peripheral tissues including cardiac muscle and vascular smooth muscle, and have been designated as 'peripheral benzodiazepine receptor'. Benzodiazepines have been shown...
In vitro pharmacological characteristics of SKP-450, a novel K+ channel opener, in non-vascular smooth muscles in comparison with levcromakalim

Hong KW, Park JY, Kim HH, Yoo SE

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):759-767.
In the present study, we characterized the non-vascular smooth muscle relaxant effects of a novel benzoyran derivative, SKP-450 (2-(2"(1",3"-dioxolone)-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6-nitro- 2H-1-benzopyran) and its metabolite, SKP-310, in comparison with levcromakalim (LCRK). In the rat stomach fundus,...
Pretreatment of hyperbaric oxygenation increases the activities of myocardial antioxidant enzymes and protects the ischemia-reperfusion injury of the heart

Oh DJ, Kim YH, Kim CH, Park JW, Kim MS

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):749-758.
Myocardial ischemia-reperfusion injury is known to be mediated by reactive oxygen species. The myocardial cell is equipped with endogenous antioxidant defensive system which can be adaptively stimulated by various oxidative stress. It is...
Effect of metabolic inhibition on inward rectifier K current in single rabbit ventricular myocytes

Chung YJ, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):741-748.
In the present study, we have investigated the effect of metabolic inhibition on the inward rectifer K current (IK1). Using whole cell patch clamp technique we applied voltage ramp from +80 mV...
Effects of cyclic-GMP on hyperpolarization-activated inward current (I|f) in sino-atrial node cells of rabbit

Shin Y, Ho WK, Earm YE

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):731-739.
The aim of present study is to investigate the effects of cGMP on hyperpolarization activated inward current (If), pacemaker current of the heart, in rabbit sino-atrial node cells using the whole-cell patch clamp...
Regulation of Mg2+ release in guinea pig heart and isolated ventricular myocytes by alpha1-adrenergic stimulation

Kang HS, Chang SE, Kim JS

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):717-730.
Mg2+ is the fourth most abundant cation in cellular organisms. Although the biological chemistry and the physiological roles of the magnesium ion were well known, the regulation of intracellular Mg2+ in mammalian cells...
Studies on the roles of Na+/-Ca2+ exchange according to postnatal age in the negative staircase effect of the rat heart

Lee HY, Kim SJ, Ko CM

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):707-716.
Recent reports revealed that the Na+/-Ca2+ exchangers and feet structures of sarcoplasmic reticulum (SR) are located in close vicinity in the specific compartment. Therefore, we investigated the possibility that the Na+/-Ca2+ exchanger may...
Apoptotic process is involved in the L-glutamate-induced PC12 cell death

Sung KW, Jung KH, Kim SY, Kang JH, Lee SB

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):699-705.
Although it is known that neuronal cell death during development occurs by apoptosis, the mechanisms underlying excitatory amino acid-induced neuronal cell death remain poorly understood. In this study we have examined the mechanism...
The c-myc expression on the opioid tolerance in human neuroblastoma SH-SY5Y cells

Kim SK, Park CK, Kwon GY, Suh SI

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):691-697.
The mechanisms underlying opiate tolerance and dependence are not fully understood. We used human neuroblastoma SH-SY5Y cells as a model system for studying effects of morphine tolerance and withdrawal on c-myc induction and...
Effects of K+ channel modulators on extracellular K+ accumulation during ischemia in the rat hippocampal slice

Choi JK, Chun BG, Ryu PD

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):681-690.
Loss of synaptic transmission and accumulation of extracellular K+((K+)o) are the key features in ischemic brain damage. Here, we examined the effects of several K+ channel modulators on the early ischemic changes in...
Role of nitric oxide in ischemia-evoked release of norepinephrine from rat cortex slices

Kim KW, Eun YA, Kim DC, Cho KP

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):673-679.
It has been generally accepted that glutamate mediates the ischemic brain damage, excitotoxicity, and induces release of neurotransmitters, including norepinephrine (NE), in ischemic milieu. In the present study, the role of nitric oxide...
Effect of PAF antagonists on the nitric oxide synthesis in ischemic cerebral cortex

Lee WS, No SK, Park KH

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):665-672.
This study aimed to investigate the mechanism of cerebroprotection of platelet-activating factor (PAF) antagonists in transient cerebral ischemia of rat. Right middle cerebral artery (MCA) of Sprague-Dawley rat was occluded for 2 hours...
Effect of adenosine on the release of (3H)-5-hydroxytryptamine during glucose/oxygen deprivation from rat hippocampal slices

Lee KE, Cha KE, Pae YS

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):657-664.
The effects of adenosine, adenosine A1 receptor antagonist (DPCPX), or NMDA receptor antagonist (APV) on the spontaneous release of (3H)-5-hydroxytryptamine ((3H)-5-HT) during normoxic/normoglycemic or hypoxic/hypoglycemic period were studied in the rat hippocampal slices. The...
Effects of cyclic nucleotides and glipizide on the cardiovascular response of baclofen in the rats

Shin IC, Koh HC, Ha JH

  • Korean J Physiol Pharmacol.
  • 1997 Dec;1(6):647-655.
The purpose of present study is to investigate the influence of a spinal gamma-aminobutyric acid B(GABA|B) receptor on a central regulation of blood pressure (BP) and heart rate (HR), and to define its...

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