- Toward a grey box approach for cardiovascular physiome
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Hwang M, Leem CH, Shim EB
- KMID: 2455806
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):305-310.
- doi: 10.4196/kjpp.2019.23.5.305
The physiomic approach is now widely used in the diagnosis of cardiovascular diseases. There are two possible methods for cardiovascular physiome: the traditional mathematical model and the machine learning (ML)... -
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- Theoretical Estimation of Cannulation Methods for Left Ventricular Assist Device Support as a Bridge to Recovery
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Lim KM, Lee JS, Song JH, Youn CH, Choi JS, Shim EB
- KMID: 1786015
- J Korean Med Sci.
- 2011 Dec;26(12):1591-1598.
- doi: 10.3346/jkms.2011.26.12.1591
Left ventricular assist device (LVAD) support under cannulation connected from the left atrium to the aorta (LA-AA) is used as a bridge to recovery in heart failure patients because it... -
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- Minimal systems analysis of mitochondria-dependent apoptosis induced by cisplatin
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Hong JY, Hara K, Kim JW, Sato EF, Shim EB, Cho KH
- KMID: 2371054
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):367-378.
- doi: 10.4196/kjpp.2016.20.4.367
Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a... -
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- Computational Quantification of the Cardiac Energy Consumption during Intra-Aortic Balloon Pumping Using a Cardiac Electromechanics Model
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Lim KM, Lee JS, Gyeong MS, Choi JS, Choi SW, Shim EB
- KMID: 2158007
- J Korean Med Sci.
- 2013 Jan;28(1):93-99.
- doi: 10.3346/jkms.2013.28.1.93
To quantify the reduction in workload during intra-aortic balloon pump (IABP) therapy, indirect parameters are used, such as the mean arterial pressure during diastole, product of heart rate and peak... -
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- Computational Analysis of Tumor Angiogenesis Patterns Using a Two-dimensional Model
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Shim EB, Kwon YG, Ko HJ
- KMID: 1734055
- Yonsei Med J.
- 2005 Apr;46(2):275-283.
- doi: 10.3349/ymj.2005.46.2.275
Tumor angiogenesis was simulated using a two-dimensional computational model. The equation that governed angiogenesis comprised a tumor angiogenesis factor (TAF) conservation equation in time and space, which was solved numerically... -
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- Development and Clinical Validity of a Mild Vascular Cognitive Impairment Assessment Tool for Korean Stroke Patients
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Oh HS, Kim JS, Shim EB, Seo WS
- KMID: 2344321
- Asian Nurs Res.
- 2015 Sep;9(3):226-234.
- doi: 10.1016/j.anr.2015.04.005
PURPOSE: The present study was conducted to develop a mild vascular cognitive impairment (MVCI) assessment tool for patients with stroke and to examine its validity, reliability, and clinical adequacy. METHODS: Items... -
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- Inducibility of human atrial fibrillation in an in silico model reflecting local acetylcholine distribution and concentration
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Hwang M, Lee HS, Pak HN, Shim EB
- KMID: 2150480
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):111-117.
- doi: 10.4196/kjpp.2016.20.1.111
Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of... -
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- An Integrative Model of the Cardiovascular System Coupling Heart Cellular Mechanics with Arterial Network Hemodynamics
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Kim YT, Lee JS, Youn CH, Choi JS, Shim EB
- KMID: 1793020
- J Korean Med Sci.
- 2013 Aug;28(8):1161-1168.
- doi: 10.3346/jkms.2013.28.8.1161
The current study proposes a model of the cardiovascular system that couples heart cell mechanics with arterial hemodynamics to examine the physiological role of arterial blood pressure (BP) in left... -
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- In silico evaluation of the acute occlusion effect of coronary artery on cardiac electrophysiology and the body surface potential map
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Ryu AJ, Lee KE, Kwon SS, Shin ES, Shim EB
- KMID: 2443618
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):71-79.
- doi: 10.4196/kjpp.2019.23.1.71
Body surface potential map, an electric potential distribution on the body torso surface, enables us to infer the electrical activities of the heart. Therefore, observing electric potential projected to the... -
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- Numerical Simulation of the Effect of Sodium Profile on Cardiovascular Response to Hemodialysis
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Lim KM, Choi SW, Min BG, Shim EB
- KMID: 1793193
- Yonsei Med J.
- 2008 Aug;49(4):581-591.
- doi: 10.3349/ymj.2008.49.4.581
PURPOSE: We developed a numerical model that predicts cardiovascular system response to hemodialysis, focusing on the effect of sodium profile during treatment. MATERIALS and METHODS: The model consists of a... -
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- Computational analysis of the electromechanical performance of mitral valve cerclage annuloplasty using a patient-specific ventricular model
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Lee KE, Kim KT, Lee JH, Jung S, Kim JH, Shim EB
- KMID: 2443617
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):63-70.
- doi: 10.4196/kjpp.2019.23.1.63
We aimed to propose a novel computational approach to predict the electromechanical performance of pre- and post-mitral valve cerclage annuloplasty (MVCA). Furthermore, we tested a virtual estimation method to optimize... -
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- The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study
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Yun Y, Hwang M, Park JH, Shin H, Shim EB, Pak HN
- KMID: 1734924
- J Korean Med Sci.
- 2014 Mar;29(3):370-377.
- doi: 10.3346/jkms.2014.29.3.370
Although complex fractionated electrogram (CFE) is known to be a target for catheter ablation of fibrillation, its physiological meaning in fibrillation wave-dynamics remains to be clarified. We evaluated the spatiotemporal... -
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- Spatial reproducibility of complex fractionated atrial electrogram depending on the direction and configuration of bipolar electrodes: an in-silico modeling study
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Song JS, Lee YS, Hwang M, Lee JK, Li C, Joung B, Lee MH, Shim EB, Pak HN
- KMID: 2350507
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):507-514.
- doi: 10.4196/kjpp.2016.20.5.507
Although 3D-complex fractionated atrial electrogram (CFAE) mapping is useful in radiofrequency catheter ablation for persistent atrial fibrillation (AF), the directions and configuration of the bipolar electrodes may affect the electrogram.... -
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