- FSL-1, a Toll-like Receptor 2/6 Agonist, Induces Expression of Interleukin-1alpha in the Presence of 27-hydroxycholesterol
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Heo W, Kim SM, Eo SK, Rhim BY, Kim K
- KMID: 2285549
- Korean J Physiol Pharmacol.
- 2014 Dec;18(6):475-480.
- doi: 10.4196/kjpp.2014.18.6.475
We investigated the question of whether cholesterol catabolite can influence expression of inflammatory cytokines via Toll-like receptors (TLR) in monocytic cells. Treatment of THP-1 monocytic cells with 27-hydroxycholesterol (27OHChol) resulted... -
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- Comparison of Students' Characteristics and Perceptions Before and After Introduction Into Graduate Medical School System
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Yoon TH, Yune SJ, Yoon S, Lee SH, Jeong IS, Park BK, Lee SY, Chang CL, Kim HK, Rhim BY, Jeong HJ
- KMID: 2306722
- Korean J Med Educ.
- 2007 Sep;19(3):251-255.
PURPOSE: This study was performed to compare the characteristics and perceptions of medical school students and professional graduate medical school students. METHODS: Study subjects were 131 medical students from a national... -
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- A Study on Using Questions during Lectures in Medical School: Reality vs. Awareness of the Professors
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Jeong HJ, Lee SY, Kim YK, Kim YJ, Kim HK, Park NH, Park BK, Park JH, Baik SW, Woo JS, Yoon S, Lee WS, Rhim BY, Chang CL, Jeong IS
- KMID: 2306796
- Korean J Med Educ.
- 2005 Apr;17(1):83-96.
PURPOSE: Questions are known to be an important teaching technique. And, waiting for the answers is essential in making questions effective and valuable. The objective of this study is to... -
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- Alteration in Endothelin Receptor-Mediated Responses in Femoral Arteries from Hyperlipidemic Rabbits
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Suh KT, Lee CB, Shim WS, Rhim BY
- KMID: 2189546
- J Korean Orthop Assoc.
- 1999 Feb;34(1):147-155.
OBJECTIVE: To investigate the roles of ET in the regulation of peripheral vascular tone, we studied the effect of hyperlipidemia on vascular responsiveness in femoral arteries from rabbits with control... -
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- Pharmacological evidence that cromakalim inhibits Ca2+ release from intracellular stores in porcine coronary artery
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Rhim BY, Hong SH, Kim CD, Lee WS, Hong KW
- KMID: 2285155
- Korean J Physiol Pharmacol.
- 1997 Feb;1(1):27-34.
In the present study, it was aimed to further identify the intracellular action mechanism of cromakalim and levcromakaliin in the porcine coronary artery. In intact porcine coronary arterial strips loaded with fura-2/AM, acetylcholine... -
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- 7alpha-Hydroxycholesterol Elicits TLR6-Mediated Expression of IL-23 in Monocytic Cells
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Seo HC, Kim SM, Eo SK, Rhim BY, Kim K
- KMID: 2380367
- Biomol Ther.
- 2015 Jan;23(1):84-89.
- doi: 10.4062/biomolther.2014.067
We investigated the question of whether 7-oxygenated cholesterol derivatives could affect inflammatory and/or immune responses in atherosclerosis by examining their effects on expression of IL-23 in monocytic cells. 7alpha-Hydroxycholesterol (7alphaOHChol)... -
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- Expression of Nitric Oxide Synthase and Endothelin-1 in Human Uterine Artery from Full-Term Pregnancies
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Choi OH, Lee SH, Kim EJ, Kim KH, Rhim BY
- KMID: 1600059
- Korean J Physiol Pharmacol.
- 2005 Jun;9(3):165-172.
The aim of this study was to determine the roles of ET-1 and NO on uterine blood flow in pregnancy. Uterine arteries were isolated from 17 nonpregnant and 12 pregnant... -
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- Multiple Signaling Pathways Contribute to the Thrombin-induced Secretory Phenotype in Vascular Smooth Muscle Cells
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Jeong JY, Son Y, Kim BY, Eo SK, Rhim BY, Kim K
- KMID: 2070795
- Korean J Physiol Pharmacol.
- 2015 Nov;19(6):549-555.
- doi: 10.4196/kjpp.2015.19.6.549
We attempted to investigate molecular mechanisms underlying phenotypic change of vascular smooth muscle cells (VSMCs) by determining signaling molecules involved in chemokine production. Treatment of human aortic smooth muscle cells... -
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- Roles of ERK and NF-kappa B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
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Kang SH, Lee JH, Choi KH, Rhim BY, Kim K
- KMID: 1838355
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):171-176.
- doi: 10.4196/kjpp.2008.12.4.171
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate... -
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- Development and Assessment of Multimedia Learning Tool on Clinical Microbiology for Undergraduate Medical Students
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Oh SH, Lee SM, Kim HH, Lee EY, Jeong HJ, Lee SY, Kim SS, Kim HK, Park BK, Woo JS, Rhim BY, Baik SW, Jeong IS, Chang CL
- KMID: 2306757
- Korean J Med Educ.
- 2006 Aug;18(2):161-170.
PURPOSE: Insufficient teaching of clinical microbiology, often caused by limited resources in medical schools, might be a reason for inaccurate diagnosis and treatment of infectious diseases by doctors. The purpose... -
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- The Cholesterol-Binding Antibiotic Nystatin Induces Expression of Macrophage Inflammatory Protein-1 in Macrophages
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Baek S, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2170684
- Biomol Ther.
- 2013 Jan;21(1):42-48.
Nystatin, a polyene antifungal antibiotic, is a cholesterol sequestering agent. The antifungal agent alters composition of the plasma membrane of eukaryotic cells, whereas its effects on cells are poorly investigated.... -
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- Conditioned Medium from Dying Smooth Muscle Cell Induced Apoptotic Death
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Bu MH, Lee KA, Kim KH, Rhim BY
- KMID: 2071613
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):315-322.
In this study, the authors investigated whether death of vascular smooth muscle cell (VSMC) had a pathological pertinence. Conditioned media obtained from rat aorta smooth muscle cell (SMC) that were... -
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- Changes in the endothelin-1-induced contraction of aorta in streptozotocin-induced diabetic rats.
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Cheong HJ, Kim EJ, Kim SJ, Lee SH, Rhim BY
- KMID: 1580805
- Korean J Physiol Pharmacol.
- 2000 Jun;4(3):185-195.
Vascular diseases are significant complications of diabetes mellitus (DM), and the endothelial cells may play a pivotal role in the development of vascular disease in DM. Endothelin-1 (ET-1) released from endothelium is a... -
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- Synergistic Efficacy of Concurrent Treatment with Cilostazol and Probucol on the Suppression of Reactive Oxygen Species and Inflammatory Markers in Cultured Human Coronary Artery Endothelial Cells
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Park SY, Lee JH, Shin HK, Kim CD, Lee WS, Rhim BY, Shin YW, Hong KW
- KMID: 1838354
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):165-170.
- doi: 10.4196/kjpp.2008.12.4.165
In the present study, we aimed to identify the synergistic effects of concurrent treatment of low concentrations of cilostazol and probucol to inhibit the oxidative stress with suppression of inflammatory... -
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- Angiotensin II-induced aortic ring constriction is mediated by phosphatidylinositol 3-kinase/L-type calcium channel signaling pathway
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Do KH, Kim MS, Kim JH, Rhim BY, Lee WS, Kim CD, Bae SS
- KMID: 1119322
- Exp Mol Med.
- 2009 Aug;41(8):569-576.
- doi: 10.3858/emm.2009.41.8.062
Angiotensin II (AngII) is a crucial hormone that affects vasoconstriction and exerts hypertrophic effects on vascular smooth muscle cells. Here, we showed that phosphatidylinositol 3-kinase-dependent calcium mobilization plays pivotal roles... -
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- Mechanisms underlying relaxations caused by angiotensin II and its analogs in isolated rabbit mesenteric artery
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Hong KW, Park JY, Kim CD, Lee WS, Rhim BY, Yoo SE
- KMID: 2071511
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):393-402.
In the present study, we characterized the angiotensin II (AII)-induced relaxations in the phenylephrineprecontracted rabbit mesenteric arteries with endothelium. 1) AII-induced relaxation was consistently observed in the rabbit mesenteric arteries with and without endothelium,... -
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- Contractile Responses to Endothelins in Isolated Arteries from Human Uterus
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Choi OH, Jang MK, Rhim BY
- KMID: 2261368
- Korean J Obstet Gynecol.
- 1999 Mar;42(3):582-590.
OBJECTIVE: We examined the vasoconstricting poperties of endothelin (ET) on isolated arteries from pregnant as well as non-pregnant uterus. METHODS: Arteries of the uterus were obtained from both hysterectomized uterus... -
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- Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages
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Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2285454
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):447-453.
- doi: 10.4196/kjpp.2012.16.6.447
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to... -
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- Extracellular Nucleotides Can Induce Chemokine (C-C motif) Ligand 2 Expression in Human Vascular Smooth Muscle Cells
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Kim JI, Kim HY, Kim SM, Lee SA, Son YH, Eo SK, Rhim BY, Kim K
- KMID: 2389106
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):31-36.
To understand the roles of purinergic receptors and cellular molecules below the receptors in the vascular inflammatory response, we determined if extracellular nucleotides up-regulated chemokine expression in vascular smooth muscle... -
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- Characterization of ETB Receptor-mediated Relaxation in Precontracted Mesenteric Artery from Streptozotocin-induced Diabetic Rats
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Eom YK, Kim KH, Rhim BY
- KMID: 1600114
- Korean J Physiol Pharmacol.
- 2005 Oct;9(5):305-314.
Diabetes mellitus is associated with vascular complications, including an impairment of vascular function and alterations in the reactivity of blood vessels to vasoactive substances in various vasculature. In the present... -
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