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Hyaluronic acid has chondroprotective and joint-preserving effects on LPS-induced synovitis in horses

Neuenschwander HM, Moreira JJ, Vendruscolo CP, Fülber J, Seidel SR, Michelacci YM, Baccarin R

The intra-articular use of hyaluronic acid (HA) for the treatment of synovitis and osteoarthritis is still controversial. As a consequence, corticosteroids remain the most frequently employed therapeutic agents, despite their...
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Neutrophil oxidative burst as a diagnostic indicator of IgG-mediated anaphylaxis

Won DI, Kim S, Lee EH

BACKGROUND: IgG-mediated anaphylaxis occurs after infusion of certain monoclonal antibody-based therapeutics. New in vitro tests are urgently needed to diagnose such reactions. We investigated whether allergens trigger neutrophil oxidative burst...
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Evaluation of Platelet-Rich Plasma and Neutrophil Antimicrobial Extract as Two Autologous Blood-Derived Agents

Szponder T, Wessely-Szponder J, Smolira A

The platelet-rich plasma (PRP) and antimicrobial peptides neutrophil extract (AMP extract) were prepared from rabbit neutrophils as two autologous blood-derived preparations, which could be applied locally to enhance healing process...
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Characterization of Lactobacillus reuteri BCLR-42 and Lactobacillus plantarum BCLP-51 as novel dog probiotics with innate immune enhancing properties

Kim EJ, Kang YI, Bang TI, Lee MH, Lee SW, Choi IS, Song CS, Lee JB, Park SY

Probiotics that are able to provide beneficial effects on animal health have become important ingredients of dog foods. This study was conducted to characterize the probiotic potentials of two strains,...
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Phenotypic and Functional Analysis of HL-60 Cells Used in Opsonophagocytic-Killing Assay for Streptococcus pneumoniae

Kim KH, Seoh JY, Cho SJ

Differentiated HL-60 is an effector cell widely used for the opsonophagocytic-killing assay (OPKA) to measure efficacy of pneumococcal vaccines. We investigated the correlation between phenotypic expression of immunoreceptors and phagocytic...
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Respiratory epithelial cell lines exposed to anoxia produced inflammatory mediator

Shahriary , Chin TW, Nussbaum E

Human epithelial cell lines were utilized to examine the effects of anoxia on cellular growth and metabolism. Three normal human epithelial cells lines (A549, NHBE, and BEAS-2B) as well as...
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The effect of conglutinin on production of reactive oxygen species in bovine granulocytes

Dec M, Wernicki A, Puchalski , Urban-Chmiel R, Wasko A

Conglutinin is a high molecular-weight lectin originally detected in bovine serum. It belongs to the family of collectins that bind sugar residues in a Ca(2+)-dependent manner and are effector molecules...
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A Study on the Mechanism of Immunomodulating Effects of Moxifloxacin in Oleic Acid-Induced Acute Lung Injury

Lee YM

BACKGROUND: It was hypothesized that the immunomodulating effects of moxifloxacin contribute to ameliorate oleic acid (OA)-induced acute lung injury (ALI) by suppression of cytosolic phospholipase A2 (cPLA2). This was based...
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Moxifloxacin Alleviates Oleic Acid-provoked Neutrophilic Respiratory Burst in the Rat Lung through the Inhibition of Cytosolic Phospholipase A2

Lee YM

BACKGROUND: According to the notion of the immunoregulatory functions of moxifloxacin (MFX), the effect of MFX on the neutrophilic respiratory burst in conjunction with the expression of cytosolic phospholipase A2...
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Moxifloxacin Ameliorates Oleic Acid-induced Acute Lung Injury by Modulation of Neutrophilic Oxidative Stress in Rats

Kim BY, Lee YM

BACKGROUND: Based on the known immunoregulatory functions of moxifloxacin on phagocytes, the therapeutic effect of moxifloxacin on oleic acid (OA)-induced acute lung injury (ALI) was investigated. METHODS: Moxifloxacin (10 mg/kg) was...
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Role of the PLA2-Activated Neutrophilic Oxidative Stress in Oleic Acid-Induced Acute Lung Injury

Lee YM, Kim BY, Park YY

BACKGROUND: The underlying pathogenesis of fat embolism-induced acute lung injury (ALI) has not been elucidated. In the present study, the pathogenesis of fat embolism-induced ALI was probed in association with...
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Non-specific Immune Response of Rainbow Trout (Oncorhynchus Mykiss) by Dietary Heat-inactivated Potential Probiotics

Choi SH, Yoon TJ

BACKGROUND: The effects of the dietary administration of two heat-inactivated whole bacteria from the Vibrionaceae family, singly or combined, on innate immune response of the rainbow trout were studied. The...
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Cytosolic Phospholipase A2 Activity in Neutrophilic Oxidative Stress of Platelet-activating Factor-induced Acute Lung Injury

Kwon YS, Hyun DS, Lee YM

  • KMID: 2318980
  • Tuberc Respir Dis.
  • 2007 Dec;63(6):497-506.
BACKGROUND: The present investigation was performed in rats and isolated human neutrophils in order to confirm the presumptive role of the positive feedback loop of cytosolic phospholipase A2 (cPLA2) activation...
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A Case of Chronic Neutrophilic Leukemia with Multiple Myeloma and an Increased Function of Her Neutrophils

Kim S, Park CJ, Lee KH, Jang S, Chi HS, Seo EJ

We describe here a 64-year-old woman who simultaneously presented with chronic neutrophilic leukemia (CNL) and multiple myeloma (MM). The patient presented with mature neutrophilic leukocytosis, hepatosplenomegaly, the absence of Philadelphia...
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Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 after Administration of Endotoxin in Diabetic Rats

Seo KH, Choi JS, Na JO, Uh ST, Kim YH, Park CS

BACKGROUND: An acute lung injury(ALI) is characterized by the recruitment, activation, and apoptosis of inflammatory cells, numerous products released by inflammatory cells such as reactive oxygen species, inflammatory mediators, and...
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Age-Related Decrease and a Simple Flow Cytometric Assay of Neutrophil Function

Won DI, Heo WB, Suh JS

  • KMID: 2038262
  • Korean J Lab Med.
  • 2005 Aug;25(4):273-279.
BACKGROUND: We intended to confirm a decline in neutrophil function with aging and to devise a simple neutrophil function test protocol for use in a clinical setting. Reversely, the reliability...
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Neutrophil Apoptosis and H2O2 Release by LPS in Diabetics

Seo KH, Na JO, Moon SH, Uh ST, Kim YH, Park CS

BACKGROUND: Bacterial infections in diabetic patients are an important cause of increased morbidity and mortality. It has been reported that bacterial infections in diabetics showed more impaired PMN functions such...
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Increased Reactive Oxygen Species Production by Peripheral Blood Mononuclear Leukocytes, not by Polymorphonuclear Leukocytes, in Atopic Dermatitis

Huh EJ, Ryu KH, Huh JK, Yoon JS, Kim YH, Kim JT, Hahn H, Lee KH, Lee JS

  • KMID: 2314310
  • Pediatr Allergy Respir Dis.
  • 2004 Mar;14(1):53-61.
PURPOSE: Reactive oxygen species (ROS) are known as a potential mediators that sustain chronic inflammation in atopic dermatitis (AD). To determine the role of peripheral blood mononuclear leukocytes (MO) and...
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Hydrogen Peroxide Modulates Phospholipase A2 Aactivity and Endogenous Oxidative Stress in the Free Radical Induced Acute Lung Injury

Bae CH, Kang HS, Lee S, Jheon SH, Ahn WS, Kwon OC

  • KMID: 2288967
  • Korean J Thorac Cardiovasc Surg.
  • 2002 May;35(5):343-349.
BACKGROUND: In an attempt to investigate the role of oxidants in the activation of phospholipase A2(PLA2) and endogenous oxidative stress in the lung, acute inflammatory lung injury was induced by...
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Phospholipase A2 Contributes to Hemorrhage-induced Acute Lung Injury Through Neutrophilic Respiratory Burst

Jang YS, Kim SE, Jheon SH, Shin TR, Lee YM

BACKGROUND: The present study was carried out in association with neutrophilic respiratory burst in the lung in order to clarify the pathogenesis of acute respiratory distress syndrome(ARDS) following acute severe...
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