Korean J Hematol.
2001 Nov;36(4):359-363.
A Case of Chronic Neutrophilic Leukemia Associated with Increased Respiratory Burst Activity of Neutrophils
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea. moisa@ewha.ac.kr
- 2Department of Microbiology, College of Medicine, Ewha Womans University, Seoul, Korea.
- 3Department of Clinical Pathology, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
- Chronic neutrophilic leukemia is a rare myeloproliferative disorder. We have experienced a typical case of chronic neutrophilic leukemia in a 76-year-old man who complained abdominal distension due to hepatosplenomegaly. White blood cell count of peripheral blood was 50,500/nL with 90% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score and the serum levels of vitamin B12 and uric acid were elevated. Chromosome study showed a normal karyotype without Philadelphia chromosome or bcr/abl rearrangement. Phorbol myristate acetate-activated respiratory burst activity of neutrophils measured with chemiluminescence showed increased activity.
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