- Cholinergic activity related to cardiovascular regulation in rostral ventrolateral medulla of spontaneously hypertensive rats
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Lee SY, Lee SB
- KMID: 1917067
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):29-34.
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to... -
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- Electron Microscopic Study of Enalapril Effect on Left Ventricular Hypertrophy in Spontaneously Hypertensive Rat
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Lee BH, Kim JH, Lim HK, Lee CK, Choi IG
- KMID: 2229373
- Korean Circ J.
- 1990 Jun;20(2):232-241.
- doi: 10.4070/kcj.1990.20.2.232
Left ventricular hypertrophy is a compensatory response to hemodynamic overload secondary to an increased systemic resistance. This increase, however, is not the only cause of hypertrophy, and there are other... -
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- Effect of Thiopental and Thiamylal on Isolated Thoracic Aorta in Normotensive and Spontaneously Hypertensive Rats
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Kim SH, Park JW, Kim BK
- KMID: 1933070
- Korean J Anesthesiol.
- 1988 Dec;21(6):889-897.
- doi: 10.4097/kjae.1988.21.6.889
The present study was undertaken to measure the effects of thiopental and thiamylal on isolated thoracic aortic hlical strips in normotensive Wistar rats(NWR) and spontaneously hypertensive rats(SHR). Phenylphrine(10(-9) ~ 10(-5)... -
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- Studies on the structural changes of aortic media and its repairing effect by enalapril in spontaneously hypertensive rats
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Hong SP, Chung CH
- KMID: 2229234
- Korean Circ J.
- 1993 Jun;23(3):426-439.
- doi: 10.4070/kcj.1993.23.3.426
BACKGROUND: It has been known that arteries of hypertensive animals and patients are generally thicker and more rigid than those of normal subjects, resulting from the morphological changes induced by... -
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- Altered Cellular Kinetics in the Growth Plate of the Femoral Head of Spontaneously Hypertensive Rats
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Park H, Kong SY, Kim HW
- KMID: 1777000
- Yonsei Med J.
- 2012 May;53(3):625-633.
- doi: 10.3349/ymj.2012.53.3.625
PURPOSE: Pathologic changes in the growth plate remain unknown in Legg-Calve-Perthes (LCP) disease. Spontaneously hypertensive rats have proven to be a good model for studying LCP disease. This study investigated... -
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- Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
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Kim SH, Chu YK, Kwon OW, McCune SA, Davidorf F
- KMID: 711583
- Yonsei Med J.
- 1998 Oct;39(5):453-462.
- doi: 10.3349/ymj.1998.39.5.453
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the... -
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- Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats
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Kim SW, Moon KH, Lee SC, Kim NH, Kang DG, Lee JU, Choi KC, Kang YJ
- KMID: 759080
- Korean J Intern Med.
- 1999 Jan;14(1):21-26.
OBJECTIVES: The present study was aimed at exploring whether the pathogenesis of hypertension is related with an altered expression of nitric oxide synthase (NOS) isozymes, i.e., bNOS, iNOS... -
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- Changes in Myogenic Tone in Spontaneously Hypertensive Rat: Role of RhoA and Protein Kinase C
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Seo JP, Ryu SK, Kang NY, Ahn DS, Lee YH
- KMID: 1938907
- Korean Circ J.
- 2002 Mar;32(3):257-267.
- doi: 10.4070/kcj.2002.32.3.257
BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular... -
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- Effect of adenosine analogues on the plasma renin concentration in spontaneously hypertensive rats
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Park IS, Kang CW, Kim SH, Cho KW
- KMID: 1686841
- J Korean Soc Endocrinol.
- 1993 Mar;8(1):42-50.
No abstract available. -
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- Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment
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Lee SW, Kim Y, Kim KC, Sohn S, Hong YM
- KMID: 2171364
- Ewha Med J.
- 2016 Apr;39(2):45-50.
- doi: 10.12771/emj.2016.39.2.45
OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system... -
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- Distributional patterns of phospholipase C isozymes in heart and brain of spontaneously hypertensive and normotensive rats
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Choi JW, Cho YJ, Cha SH, Lee KH, Lee SB
- KMID: 2071510
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):385-392.
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in... -
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- Expression of Vascular Endothelial Growth Factor in an Animal Model of Avascular Necrosis of the Femoral Head
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Yang IH, Kim SH, Kong SY, Joo SY, Yang KH, Hahn SB, Park HW, Kim HW
- KMID: 1848281
- J Korean Orthop Res Soc.
- 2004 Oct;7(2):115-124.
PURPOSE: To evaluate the pathologic changes, apoptosis of chondrocytes, and expression pattern of vascular endothelial growth factor (VEGF) in the growth plate of Spontaneouly Hypertensive Rats (SHR). MATERIALS AND METHODS: Sixty... -
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- Actions of beta-Adrenergic Stimulation for Coronary Circulation in Spontaneously Hypertensive Rat Hearts
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Kim EJ, Kang YH
- KMID: 2229317
- Korean Circ J.
- 1994 Oct;24(5):709-716.
- doi: 10.4070/kcj.1994.24.5.709
No abstract available. -
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- Effects of kimchi supplementation on blood pressure and cardiac hypertrophy with varying sodium content in spontaneously hypertensive rats
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Lee SM, Cho Y, Chung HK, Shin DH, Ha WK, Lee SC, Shin MJ
- KMID: 2313610
- Nutr Res Pract.
- 2012 Aug;6(4):315-321.
We tested the effects of dietary intake of freeze-dried Korean traditional fermented cabbage (generally known as kimchi) with varying amounts of sodium on blood pressure and cardiac hypertrophy in spontaneously... -
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- Differentially-altered vascular guanylate cyclase isoforms in experimental hypertensive rats
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Lee JU, Kang DG, Kook H, Kim IK, Oh BS
- KMID: 1731311
- J Korean Med Sci.
- 1999 Aug;14(4):386-392.
- doi: 10.3346/jkms.1999.14.4.386
Pathophysiological implications of the vascular nitric oxide (NO)/cGMP pathway were investigated in various rat models of hypertension. The expression of brain and endothelial constitutive NO synthases (bNOS, ecNOS) was determined... -
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- Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats
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Yap WB, Ahmad FM, Lim YC, Zainalabidin S
- KMID: 2364266
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):621-628.
- doi: 10.4196/kjpp.2016.20.6.621
Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of... -
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- Altered cerebral vasomotion with decreased CGRP level in pial arteries of spontaneously hypertensive rats
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Lee KH, Choi JM, Hong KW
- KMID: 2071537
- Korean J Physiol Pharmacol.
- 1998 Oct;2(5):573-580.
The study aims to identify the mechanism (s) underlying the altered vasodilatory responses of the pial artery of spontaneously hypertensive rats (SHR) under a hypothesis that calcitonin gene-related peptide (CGRP) exerts a modulator... -
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- Antihypertensive Properties of Dried Radish Leaves Powder in Spontaneously Hypertensive Rats
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Kim BR, Park JH, Kim SH, Cho KJ, Chang MJ
- KMID: 2268052
- Korean J Nutr.
- 2010 Dec;43(6):561-569.
- doi: 10.4163/kjn.2010.43.6.561
The study aim was to investigate the antihypertensive effect after oral supplementation of dried radish leaves powder (DRLP). Angiotensin-converting enzyme (ACE) activity was measured by spectrophotometric assay. The systolic blood... -
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- Prolonged hypotensive effect of human tissue kallikrein gene delivery and recombinant enzyme administration in spontaneous hypertension rats
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Sun H, Zhang L, Wang A, Xue Z
- KMID: 755661
- Exp Mol Med.
- 2004 Feb;36(1):23-27.
To evaluate the feasibility of treating hypertension by human tissue kallikrein gene (KLK1) delivery and by enzyme (rK1) administration, two recombinant vectors expressing KLK1 cDNA were constructed for gene delivery... -
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- The Study on the Na(+), K(+)-ATPase Activities of the Spontaneously Hypertensive Rats
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Won KH, Kyoung NH, Hah JS, Kim KJ
- KMID: 2093245
- Korean Circ J.
- 1988 Dec;18(4):559-574.
- doi: 10.4070/kcj.1988.18.4.559
Although the mechanism of the development of hypertension has not been fully elucidated, abnormal ion transport across the cardiovascular musle membrance may play some role in this mechanism. The elevation... -
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