- Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment
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Lee H, Kim KC, Hong YM
- KMID: 2447196
- Korean J Pediatr.
- 2019 Mar;62(3):95-101.
- doi: 10.3345/kjp.2018.06856
PURPOSE: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by... -
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- Potentiation of endothelium-dependent vasorelaxation of mesenteric arteries from spontaneously hypertensive rats by gemigliptin, a dipeptidyl peptidase-4 inhibitor class of anti-diabetic drug
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Kim HJ, Baek EB, Kim SJ
- KMID: 2430094
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):713-719.
- doi: 10.4196/kjpp.2018.22.6.713
Dipeptidyl peptidase4 (DPP4) inhibitors such as gemigliptin are anti-diabetic drugs elevating plasma concentration of incretins such as GLP-1. In addition to the DPP4 inhibition, gemigliptin might directly improve the functions... -
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- Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats
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Jin JY, Park EH, Jeon YA, Lee YJ
- KMID: 2394909
- Korean J Vet Res.
- 2017 Sep;57(3):181-187.
- doi: 10.14405/kjvr.2017.57.3.181
Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10... -
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- Sulfatase 1 mediates the inhibitory effect of angiotensin II type 2 receptor inhibitor on angiotensin II-induced hypertensive mediator expression and proliferation in vascular smooth muscle cells from spontaneously hypertensive rats
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Kim HY, Cha HJ, Kim HS
- KMID: 2400328
- Yeungnam Univ J Med.
- 2017 Jun;34(1):43-54.
- doi: 10.12701/yujm.2017.34.1.43
BACKGROUND: Extracellular sulfatases (Sulfs), sulfatase 1 (Sulf1) and sulfatase 2 (Sulf2), play a pivotal role in cell signaling by remodeling the 6-O-sulfation of heparan sulfate proteoglycans on the cell surface.... -
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- Lactobacillus casei strain C1 attenuates vascular changes in spontaneously hypertensive rats
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Yap WB, Ahmad FM, Lim YC, Zainalabidin S
- KMID: 2364266
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):621-628.
- doi: 10.4196/kjpp.2016.20.6.621
Hypertension can be caused by various factors while the predominant causes include increase in body fluid volume and resistance in the circulatory system that elevate the blood pressure. Consumption of... -
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- Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment
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Lee SW, Kim Y, Kim KC, Sohn S, Hong YM
- KMID: 2171364
- Ewha Med J.
- 2016 Apr;39(2):45-50.
- doi: 10.12771/emj.2016.39.2.45
OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system... -
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- Does Methylphenidate Affect Cystometric Parameters in Spontaneously Hypertensive Rats?
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Kim KH, Jung HB, Choi DK, Park GH, Cho ST
- KMID: 2380830
- Int Neurourol J.
- 2015 Jun;19(2):67-73.
- doi: 10.5213/inj.2015.19.2.67
PURPOSE: Methylphenidate (MPH) is one of the most commonly prescribed psychostimulants for attention deficit hyperactivity disorder (ADHD). However, there is limited research on its effects on lower urinary tract function.... -
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- The Effects of CCl4 on the Expressions of Aquaporin and Superoxide Dismutase in the Kidney of the Spontaneously Hypertensive Rat
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Kim KT, Lee D, Seo YK, Kim SY
- KMID: 2283757
- Korean J Phys Anthropol.
- 2015 Jun;28(2):87-101.
- doi: 10.11637/kjpa.2015.28.2.87
Carbon tetrachloride (CCl4) induces hepatocellular damage, resulting in liver cirrhosis by generating reactive oxygen species (ROS). At the stage of decompensated liver cirrhosis, many patients suffer from the abnormal regulation... -
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- CCL5 Inhibits Elevation of Blood Pressure and Expression of Hypertensive Mediators in Developing Hypertension State Spontaneously Hypertensive Rats
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Kim HY, Cha HJ, Choi JH, Kang YJ, Park SY, Kim HS
- KMID: 2149214
- J Bacteriol Virol.
- 2015 Jun;45(2):138-150.
- doi: 10.4167/jbv.2015.45.2.138
CCL5, a proinflammatory chemokine, has been shown to attenuate angiotensin (Ang) II-induced expression of hypertensive mediators as well as Ang II-induced inhibition of anti-hypertensive mediator expression in vascular smooth muscle... -
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- Beneficial effects of ethanol extracts of Red Liriope platyphylla on vascular dysfunction in the aorta of spontaneously hypertensive rats
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Lee YJ, Koh EK, Kim JE, Go J, Song SH, Seong JE, Son HJ, Kang BC, Hwang DY
- KMID: 1787647
- Lab Anim Res.
- 2015 Mar;31(1):13-23.
- doi: 10.5625/lar.2015.31.1.13
Some biological effects of Red Liriope platyphylla (RLP) on various chronic diseases including Alzheimer's disease, diabetes and obesity were suggested after a report of the production from Liriope platyphylla (L.... -
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- The Effect of tolterodine Via Oral and Intravenous Administrations on Voiding in Awake Spontaneously Hypertensive Rats as an Overactive Bladder Model
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Lee SY, Jin LH, Kwon YH, Jang JH, Kang YJ, Yoon SM, Lee T
- KMID: 2331556
- J Korean Continence Soc.
- 2009 Dec;13(2):152-158.
PURPOSE: We investigated the effect of oral or intravenous tolterodine on cystometric parameters in awake spontaneously hypertensive rats (SHRs) as a model of overactive bladder (OAB). The aim of our... -
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- Reduction of Brain Infarct Size and Extracellular Glutamate Accumulation by Dihydrokinate in Spontaneously Hypertensive Rat after Transient Forebrain Ischemia
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Zhang YH, Cai ZH, Chen Y, Li YC
- KMID: 1588443
- J Korean Neurosurg Soc.
- 2004 Oct;36(4):310-316.
No abstract available. -
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- Supplementary Effect of Lentinus Edodes on Serum and Hepatic Lipid Levels in Spontaneously Hypertensive Rat
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Lee SH, Park HJ, Cho SY, Jeong HJ
- KMID: 2269791
- Korean J Nutr.
- 2004 Sep;37(7):509-514.
This study was conducted to investigate the supplementary effects of Lentinus edodes on blood pressure and blood lipid levels in the Hypertensive Rat. We supplied 3 kinds of experimental diets... -
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- The Effect of Combination Treatment with Angiotensin Converting Enzyme Inhibitor & Angiotensin II Receptor Blocker on the Apoptosis in the Kidney and on the MAP of Spontaneously Hypertensive Rats
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Tak WT, Yoon SC, Kim YJ
- KMID: 1989563
- Korean J Nephrol.
- 2004 Jan;23(1):22-35.
BACKGROUND: Either of the angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ARB) has been known to be effective on the inhibition of progressive renal disease. The ACEI... -
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- Age-Related Changes of Catalase Immunoreactivity in the Main Olfactory Bulbs of Wistar and Spontaneously Hypertensive Rats
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Kim DS, Yoo KY, An SJ, Park SK, Hwang IK, Jung JY, Lee KW, Cho JH, Kang TC, Won MH
- KMID: 2092804
- Korean J Anat.
- 2003 Oct;36(5):353-361.
The reactive oxygen species (ROS) is well-known for the causative factors inducing ischemia, Parkinson's disease, Alzheimer, amylotrophic lateral sclerosis, hypertension and aging. Catalase (CAT) is an important endogenous antioxidant enzyme... -
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- Changes in Myogenic Tone in Spontaneously Hypertensive Rat: Role of RhoA and Protein Kinase C
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Seo JP, Ryu SK, Kang NY, Ahn DS, Lee YH
- KMID: 1938907
- Korean Circ J.
- 2002 Mar;32(3):257-267.
- doi: 10.4070/kcj.2002.32.3.257
BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular... -
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- Comparisons of Renoprotective Activities between White Ginseng Radix and Rootlet in Spontaneously Hypertensive Rats with Diabetes
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Chung SH, Ko SK, Park SH
- KMID: 1614861
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):57-61.
The renoprotective activities of white ginseng radix and rootlet were compared in spontaneously hypertensive rat (SHR) with diabetes. During oral administration of white ginseng radix (Ginseng Radix Alba, GRA) and... -
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- Apoptosis in Kidney and the Heart of the Spontaneously Hypertensive Rats
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Yoon SC, Kim YK, Kim YJ
- KMID: 2254929
- Korean J Nephrol.
- 2000 May;19(3):383-391.
BACKGROUND: The terminal features of hypertensive target organ damage include decrease in the kidney size and increase in the heart size and wall thickness. Increased apoptosis has been known in... -
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- Effect of Estrogen Replacement on Vascular Responsiveness in Ovariectomized Spontaneously Hypertensive Rat
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Seo B, Choi DJ, Hwang JY, Cheon IS, Lee YP
- KMID: 2227381
- Korean Circ J.
- 2000 Apr;30(4):528-528.
- doi: 10.4070/kcj.2000.30.4.528
BACKGROUND: Although postmenopausal estrogen replacement therapy is known to reduce cardiovascular mortality, the mechanism is not clear yet. Furthermore, the effect of estrogen on vascular tonus is reportedly variable according... -
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- The Studies of Contractile and Relaxing Responses of Abdominal Aorta and Effects of Angiotensin II Blocker(Losartan) in Spontaneously Hypertensive Rats Combined with Renovascular Hypertension
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Lee HJ, Han BK, Lee EY, Kim JS, Gal EH, Kim MH, Kim JM, Song KH, Choi SO
- KMID: 2307279
- Korean J Nephrol.
- 1999 Nov;18(6):887-893.
This study was designed to evaluate the contractile and relaxing responses of abdominal aorta in renovascular hypertension accompanied with essential hyper- tension and to examine the effect of angiotensin II... -
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