1. Delles C, McBride MW, Graham D, Padmanabhan S, Dominiczak AF. Genetics of hypertension: from experimental animals to humans. Biochim Biophys Acta. 2010; 1802:1299–1308.
2. Choi SM, Seo MJ, Kang KK, Kim JH, Ahn BO, Yoo M. Beneficial effects of the combination of amlodipine and losartan for lowering blood pressure in spontaneously hypertensive rats. Arch Pharm Res. 2009; 32:353–358.
3. Okamoto K, Aoki K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J. 1963; 27:282–293.
4. Zhang H, Wu S, Huang C, Li X. Long term treatment of spontaneously hypertensive rats with losartan and molecular basis of modulating Ito of ventricular myocytes. Mol Med Rep. 2014; 9:1959–1967.
5. Ravassa S, Fortuno MA, Gonzalez A, Lopez B, Zalba G, Fortuno A, et al. Mechanisms of increased susceptibility to angiotensin II-induced apoptosis in ventricular cardiomyocytes of spontaneously hypertensive rats. Hypertension. 2000; 36:1065–1071.
6. Cha JH, Lee HR, Kim KC, Cho MS, Hong YM. Changes of gene expressions in spontaneously hypertensive rat model after losartan treatment. Korean Circ J. 2012; 42:761–768.
7. Dai Q, Xu M, Yao M, Sun B. Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. Br J Pharmacol. 2007; 152:1042–1048.
8. Diep QN, El Mabrouk M, Yue P, Schiffrin EL. Effect of AT(1) receptor blockade on cardiac apoptosis in angiotensin II-induced hypertension. Am J Physiol Heart Circ Physiol. 2002; 282:H1635–H1641.
9. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007; 59:251–287.
10. Nishiyama A, Hitomi H, Rahman A, Kiyomoto H. Drug discovery for overcoming chronic kidney disease (CKD): pharmacological effects of mineralocorticoid-receptor blockers. J Pharmacol Sci. 2009; 109:1–6.
11. Cagnoni F, Njwe CA, Zaninelli A, Ricci AR, Daffra D, D'Ospina A, et al. Blocking the RAAS at different levels: an update on the use of the direct renin inhibitors alone and in combination. Vasc Health Risk Manag. 2010; 6:549–559.
12. Koprdova R, Cebova M, Kristek F. Long-term effect of losartan administration on blood pressure, heart and structure of coronary artery of young spontaneously hypertensive rats. Physiol Res. 2009; 58:327–335.
13. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, et al. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2007; 115:114–126.
14. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007; 25:1105–1187.
15. Fortuno MA, Ravassa S, Etayo JC, Diez J. Overexpression of Bax protein and enhanced apoptosis in the left ventricle of spontaneously hypertensive rats: effects of AT1 blockade with losartan. Hypertension. 1998; 32:280–286.
16. Zhao LL, Chen HJ, Chen JZ, Yu M, Ni YL, Zhang WF. Losartan reduced connexin43 expression in left ventricular myocardium of spontaneously hypertensive rats. J Zhejiang Univ Sci B. 2008; 9:448–454.
17. Yamamoto H, Okuzaki D, Yamanishi K, Xu Y, Watanabe Y, Yoshida M, et al. Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats. Int J Mol Med. 2013; 31:1057–1065.
18. McBride MW, Charchar FJ, Graham D, Miller WH, Strahorn P, Carr FJ, et al. Functional genomics in rodent models of hypertension. J Physiol. 2004; 554:56–63.
19. Okamoto K, Hazama F, Yamori Y, Haebara H, Nagaoka A. Pathogenesis and prevention of stroke in spontaneously hypertensive rats. Clin Sci Mol Med Suppl. 1975; 2:161s–163s.
20. Qin XP, Zeng SY, Tian HH, Deng SX, Ren JF, Zheng YB, et al. Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats. Clin Exp Pharmacol Physiol. 2009; 36:319–324.
21. Akioyamen L, Levine M, Sherifali D, O'Reilly D, Frankfurter C, Pullenayegum E, et al. Cardiovascular and cerebrovascular outcomes of long-term angiotensin receptor blockade: meta-analyses of trials in essential hypertension. J Am Soc Hypertens. 2016; 10:55–69.e1.
22. ESH/ESC Task Force for the Management of Arterial Hypertension. 2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2013; 31:1925–1938.
23. Zhao Q, Kelly TN, Li C, He J. Progress and future aspects in genetics of human hypertension. Curr Hypertens Rep. 2013; 15:676–686.