Korean J Anesthesiol.  1988 Dec;21(6):889-897. 10.4097/kjae.1988.21.6.889.

Effect of Thiopental and Thiamylal on Isolated Thoracic Aorta in Normotensive and Spontaneously Hypertensive Rats

• Kim SH
• Park JW
• Kim BK

• KMID: 1933070
• DOI: http://doi.org/10.4097/kjae.1988.21.6.889

Abstract

The present study was undertaken to measure the effects of thiopental and thiamylal on isolated thoracic aortic hlical strips in normotensive Wistar rats(NWR) and spontaneously hypertensive rats(SHR). Phenylphrine(10(-9) ~ 10(-5) M) caused a dose-dependant contraction in thoracic aortic strips contracted with 30mM KCI in NWR and SHR. The contraction induced by 30mM KCI was taken as 100% and the mean absolute values of NWR and SHR were 463+/-30 and 457+/-38mg, respectively. The ED50 of phenylphrine in thoracic aortic strips contracted with 30mM KCI in NWR and SHR was (2.3+/-1.2) X 10(-8) M and (2.1+/-1.1) X 10(-9) M, respectively. There were no significant differences in the contractile response of thoracic aorta from NWR and SHR to 30mM KCI. In helically cut strips of thoracic aorts contracted with 30mM KCI, the cumulative administration of thiopental (10(-5) ~ 10(-3) M) caused a dose related contraction in NWR and SHR. The contraction induced by 30mM KCI was taken as 100% and the mean absolute values of NWR and SHR were 496+/-31 and 541+/-69mg, respectively. There were significant differences (p<0.05 and p<0.01) in the contractile responses of thoracic aorta from NWR and SHR to thiamylal(3X10(-4) and 10(-3) M). The dose-related contraction to thiamylal was greater than that to thiopental in NWR and SHR.

Keyword

Spontaneously hypertensive rat; Thiopenta; Thiamylal; Vascular smooth muscle contraction

MeSH Terms

Aorta, Thoracic*
Rats, Inbred SHR*
Thiamylal*
Thiopental*
Thiamylal
Thiopental