- LAMC1 is a prognostic factor and a potential therapeutic target in endometrial cancer
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Kunitomi H, Kobayashi , Wu RC, Takeda T, Tominaga E, Banno K, Aoki D
- KMID: 2470864
- J Gynecol Oncol.
- 2020 Mar;31(2):e11.
- doi: 10.3802/jgo.2020.31.e11
OBJECTIVE: With the emerging significance of genetic profiles in the management of endometrial cancer, the identification of tumor-driving genes with prognostic value is a pressing need. The LAMC1 gene, encoding... -
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- Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
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Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC
- KMID: 2468466
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):338-358.
- doi: 10.4168/aair.2020.12.2.338
PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to... -
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- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
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Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells
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Cho E, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Choi HK, Chun YJ
- KMID: 2462887
- Biomol Ther.
- 2019 Nov;27(6):591-602.
- doi: 10.4062/biomolther.2019.063
Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA... -
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- Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes
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Jang HS, Lee JE, Myung CH, Park JI, Jo CS, Hwang JS
- KMID: 2462884
- Biomol Ther.
- 2019 Nov;27(6):570-576.
- doi: 10.4062/biomolther.2019.025
Particulate matter (PM), which refers to the mixture of particles present in the air, can have harmful effects. Damage to cells by PM, including disruption of organelles and proteins, can... -
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- Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⺠signaling of differentiated C2C12 myotubes
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Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM
- KMID: 2461047
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):539-547.
- doi: 10.4196/kjpp.2019.23.6.539
Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane... -
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- TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis
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Lian W, Liu X, Chen W
- KMID: 2460221
- Yonsei Med J.
- 2019 Nov;60(11):1045-1053.
- doi: 10.3349/ymj.2019.60.11.1045
PURPOSE: To explore the molecular mechanism of the upregulation of multidrug resistance-associated protein 4 (MRP4) in cholestasis. MATERIALS AND METHODS: The mRNA and protein levels of MRP4 in liver samples from... -
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- Expression Pattern and Role of Klotho in Human Hair Follicles
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Jin XH, Pi LQ, Lee WS
- KMID: 2456227
- Ann Dermatol.
- 2019 Oct;31(5):511-517.
- doi: 10.5021/ad.2019.31.5.511
BACKGROUND: Klotho protein plays a pivotal role in aging regulation. However, it is unclear whether klotho is expressed in human hair follicles and is correlated with hair growth. OBJECTIVE: The purpose... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Suppression of CD81 promotes bladder cancer cell invasion through increased matrix metalloproteinase expression via extracellular signal-regulated kinase phosphorylation
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Park HS, Lee S, Lee J, Shin HB, Yoo SM, Lee MS, Park J
- KMID: 2455968
- Investig Clin Urol.
- 2019 Sep;60(5):396-404.
- doi: 10.4111/icu.2019.60.5.396
PURPOSE: CD81 is a prognostic biomarker for high-grade bladder cancer (BC). In this study, we aimed to determine the functional mechanisms underlying the role of CD81 in BC progression. MATERIALS AND... -
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- Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2
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Cai N, Li C, Wang F
- KMID: 2452956
- Yonsei Med J.
- 2019 Aug;60(8):751-759.
- doi: 10.3349/ymj.2019.60.8.751
PURPOSE: This study aimed to explore the effects and mechanisms of long non-coding RNA (lncRNA) anti-differentiation non-coding RNA (ANCR) on the osteogenesis of osteoblast cells in postmenopausal osteoporosis (PMOP). MATERIALS AND... -
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- Long Non-Coding RNA LINC00525 Promotes the Stemness and Chemoresistance of Colorectal Cancer by Targeting miR-507/ELK3 Axis
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Wang S, Li J, Yang X
- KMID: 2465904
- Int J Stem Cells.
- 2019 Jul;12(2):347-359.
- doi: 10.15283/ijsc19041
BACKGROUND AND OBJECTIVES: This study aims to explore the effects of a long non-coding RNA, LINC00525, on colorectal cancer (CRC) and its underlying molecular mechanisms. METHODS: The qPCR, MTT, colony formation,... -
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- Long Noncoding RNA N-BLR Upregulates the Migration and Invasion of Gastric Adenocarcinoma
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Youn YH, Byun HJ, Yoon JH, Park CH, Lee SK
- KMID: 2458526
- Gut Liver.
- 2019 Jul;13(4):421-429.
- doi: 10.5009/gnl18408
BACKGROUND/AIMS: Gastric cancer is one of the most common malignant tumors worldwide with poor prognosis due to a lack of effective treatment modalities. Recent research showed that a long noncoding... -
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- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer
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Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ
- KMID: 2454281
- Cancer Res Treat.
- 2019 Jul;51(3):886-900.
- doi: 10.4143/crt.2018.375
PURPOSE: Jab1 is a coactivator of c-Jun that enhances the transcriptional function of c-Jun. Jab1 is frequently overexpressed in various cancers and is associatedwith poor prognosis of cancer patients. Thus,... -
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- Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells
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Cho SJ, Ryu JH, Surh YJ
- KMID: 2454670
- J Cancer Prev.
- 2019 Jun;24(2):112-122.
- doi: 10.15430/JCP.2019.24.2.112
BACKGROUND: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. This reduces quinone levels and thereby minimizes... -
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- MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
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Zhang C, Dai J, Fan Y, He X, Wei R
- KMID: 2448356
- Korean J Intern Med.
- 2019 May;34(3):634-642.
- doi: 10.3904/kjim.2016.315
BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples.... -
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- β-Catenin expression is associated with cell invasiveness in pancreatic cancer
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Nan JN, Kim OR, Lee MA
- KMID: 2448354
- Korean J Intern Med.
- 2019 May;34(3):618-625.
- doi: 10.3904/kjim.2017.155
BACKGROUND/AIMS: This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. METHODS: We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line. We... -
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- Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier
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Gyawali A, Krol S, Kang YS
- KMID: 2447856
- Biomol Ther.
- 2019 May;27(3):290-301.
- doi: 10.4062/biomolther.2019.007
Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of... -
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- Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells
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Kim MH, Bae CH, Choi YS, Na HG, Song SY, Kim YD
- KMID: 2447427
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):181-189.
- doi: 10.21053/ceo.2018.00493
OBJECTIVES: Endoplasmic reticulum (ER) stress is known to be associated with inflammatory airway diseases, and three major transmembrane receptors: double-stranded RNA-activated protein kinase-like ER kinase, inositol requiring enzyme 1, and... -
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