- Quercetin-induced apoptosis ameliorates vascular smooth muscle cell senescence through AMP-activated protein kinase signaling pathway
-
Kim SG, Sung JY, Kim JR, Choi HC
- KMID: 2466571
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):69-79.
- doi: 10.4196/kjpp.2020.24.1.69
Aging is one of the risk factors for the development of cardiovascular diseases. During the progression of cellular senescence, cells enter a state of irreversible growth arrest and display resistance... -
- CITED
-
- Close
- SHARE
-
- Close
- ¹H-NMR Analysis of Metabolic Changes Induced by Snf1/AMP-Activated Protein Kinase During Environmental Stress Responses
-
Kim J, Oh J, Yoon DH, Sung GH
- KMID: 2470147
- Mycobiology.
- 2019 Sep;47(3):346-349.
- doi: 10.1080/12298093.2019.1625854
AMP-activated protein kinase sucrose non-fermenting 1 (Snf1) is a representative regulator of energy status that maintains cellular energy homeostasis. In addition, Snf1 is involved in the mediation of environmental stress... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling
-
Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH
- KMID: 2458392
- J Lipid Atheroscler.
- 2019 Sep;8(2):267-276.
- doi: 10.12997/jla.2019.8.2.267
OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both... -
- CITED
-
- Close
- SHARE
-
- Close
- Humanin suppresses receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation via AMP-activated protein kinase activation
-
Kang N, Kim KW, Shin DM
- KMID: 2455817
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):411-417.
- doi: 10.4196/kjpp.2019.23.5.411
Humanin (HN) is a mitochondrial peptide that exhibits cytoprotective actions against various stresses and diseases. HN has been shown to induce the phosphorylation of AMP-activated protein kinase (AMPK), which is... -
- CITED
-
- Close
- SHARE
-
- Close
- Metformin, an Activator of AMPK, Promotes the Growth of Hair Follicles via the AMPK/β-catenin Signaling Pathway
-
Moon HR, Park KY, Kang HJ, Lee WJ, Won CH, Chang SE, Lee MW, Choi JH, Park GH
- KMID: 2449198
- Korean J Dermatol.
- 2019 May;57(4):175-181.
BACKGROUND: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous... -
- CITED
-
- Close
- SHARE
-
- Close
- Metabolic Reprogramming by the Excessive AMPK Activation Exacerbates Antigen-Specific Memory CD8⺠T Cell Differentiation after Acute Lymphocytic Choriomeningitis Virus Infection
-
Son J, Cho YW, Woo YJ, Baek YA, Kim EJ, Cho Y, Kim JY, Kim BS, Song JJ, Ha SJ
- KMID: 2444159
- Immune Netw.
- 2019 Apr;19(2):e11.
- doi: 10.4110/in.2019.19.e11
During virus infection, T cells must be adapted to activation and lineage differentiation states via metabolic reprogramming. Whereas effector CD8⺠T cells preferentially use glycolysis for their rapid proliferation, memory... -
- CITED
-
- Close
- SHARE
-
- Close
- Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
-
Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY
- KMID: 2438085
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):113-120.
- doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the... -
- CITED
-
- Close
- SHARE
-
- Close
- Poly-L-Lactic Acid Increases Collagen Gene Expression and Synthesis in Cultured Dermal Fibroblast (Hs68) Through the p38 MAPK Pathway
-
Kim SA, Kim HS, Jung JW, Suh SI, Ryoo YW
- KMID: 2430812
- Ann Dermatol.
- 2019 Feb;31(1):97-100.
- doi: 10.5021/ad.2019.31.1.97
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver
-
Cho KW, Cho DH
- KMID: 2434096
- Yeungnam Univ J Med.
- 2019 Jan;36(1):26-35.
- doi: 10.12701/yujm.2019.00059
BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in... -
- CITED
-
- Close
- SHARE
-
- Close
- Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
-
Ali A, Kim MJ, Kim MY, Lee HJ, Roh GS, Kim HJ, Cho GJ, Choi WS
- KMID: 2430195
- Anat Cell Biol.
- 2018 Dec;51(4):274-283.
- doi: 10.5115/acb.2018.51.4.274
Hyper-O-GlcNAcylation is a general feature of cancer which contributes to various cancer phenotypes, including cell proliferation and cell growth. Quercetin, a naturally occurring dietary flavonoid, has been reported to reduce... -
- CITED
-
- Close
- SHARE
-
- Close
- The Novel Neuroprotective Compound KMS99220 Has an Early Anti-neuroinflammatory Effect via AMPK and HO-1, Independent of Nrf2
-
Lee JA, Kim HR, Kim J, Park KD, Kim DJ, Hwang O
- KMID: 2424735
- Exp Neurobiol.
- 2018 Oct;27(5):408-418.
- doi: 10.5607/en.2018.27.5.408
We have previously reported a novel synthetic compound KMS99220 that prevented degeneration of the nigral dopaminergic neurons and the associated motor deficits, suggesting a neuroprotective therapeutic utility for Parkinson's disease.... -
- CITED
-
- Close
- SHARE
-
- Close
- Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
-
Moon E, Choe BM, Park JM, Chung YI, Lee BD, Park JH, Lee YM, Jeong HJ, Cheon Y, Choi Y, Park J
- KMID: 2424024
- Psychiatry Investig.
- 2018 Sep;15(9):907-913.
- doi: 10.30773/pi.2018.05.23
OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC)... -
- CITED
-
- Close
- SHARE
-
- Close
- Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
-
Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK
- KMID: 2417312
- Gut Liver.
- 2018 Jul;12(4):449-456.
- doi: 10.5009/gnl17443
BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway... -
- CITED
-
- Close
- SHARE
-
- Close
- Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes
-
Park EH, Kim JS, Lee JS, Lee YJ, Song YW, Lee EY
- KMID: 2415607
- J Rheum Dis.
- 2018 Jul;25(3):188-196.
- doi: 10.4078/jrd.2018.25.3.188
OBJECTIVE: This study examined the anti-inflammatory and chondroprotective effects of compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) patients following stimulation with interleukin (IL)-1β. METHODS: Articular cartilage samples... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-proliferative Effect of 15,16-Dihydrotanshinone I Through Cell Cycle Arrest and the Regulation of AMP-activated Protein Kinase/Akt/mTOR and Mitogen-activated Protein Kinase Signaling Pathway in Human Hepatocellular Carcinoma Cells
-
Hong JY, Park SH, Park HJ, Lee SK
- KMID: 2417368
- J Cancer Prev.
- 2018 Jun;23(2):63-69.
- doi: 10.15430/JCP.2018.23.2.63
BACKGROUND: 15,16-dihydrotanshinone I (DHTS) is a natural abietane diterpenoid that is mainly found in the roots of Salvia miltiorrhiza Bunge (Labiatae). DHTS exhibits a potential anti-proliferative effect in various human... -
- CITED
-
- Close
- SHARE
-
- Close
- Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells
-
Bae EH, Kim IJ, Choi HS, Kim HY, Kim CS, Ma SK, Kim IS, Kim SW
- KMID: 2410103
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):135-143.
- doi: 10.4196/kjpp.2018.22.2.135
Tumor necrosis factor-α (TNFα) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. We investigated the mechanisms by which TNFα-converting enzyme (TACE) contributes... -
- CITED
-
- Close
- SHARE
-
- Close
- Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
-
Koo BH, Yi BG, Jeong MS, Kwon SH, Hoe KL, Kwon YG, Won MH, Kim YM, Ryoo S
- KMID: 2440020
- Exp Mol Med.
- 2018 Feb;50(2):e438.
- doi: 10.1038/emm.2017.254
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that... -
- CITED
-
- Close
- SHARE
-
- Close
- Calcium-dependent protein kinases are potential targets for Toxoplasma gondii vaccine
-
Foroutan M, Ghaffarifar F
- KMID: 2402535
- Clin Exp Vaccine Res.
- 2018 Jan;7(1):24-36.
- doi: 10.7774/cevr.2018.7.1.24
Toxoplasma gondii belongs to the Apicomplexa phylum that caused a widespread zoonotic infection in wide range of intermediate hosts. Over one-third of the world's population are latently infected with T.... -
- CITED
-
- Close
- SHARE
-
- Close
- Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages
-
Kim JN, Han SN, Ha TJ, Kim HK
- KMID: 2390127
- Nutr Res Pract.
- 2017 Oct;11(5):357-364.
- doi: 10.4162/nrp.2017.11.5.357
BACKGROUND/OBJECTIVES: Oxidative stress is closely related with inflammation and development of many diseases. Black soybean seed coat contains high amount of anthocyanins, which are well-known for free radical scavenging activities.... -
- CITED
-
- Close
- SHARE
-
- Close
- Reserpine treatment activates AMP activated protein kinase (AMPK)
-
Park R, Lee KI, Kim H, Jang M, Ha TK, Oh WK, Park J
- KMID: 2393795
- Nat Prod Sci.
- 2017 Sep;23(3):157-161.
- doi: 10.20307/nps.2017.23.3.157
Reserpine is a well-known medicine for the treatment of hypertension, however the role of reserpine in cell signaling is not fully understood. Here, we report that reserpine treatment induces the... -
- CITED
-
- Close
- SHARE
-
- Close
