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Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics Approach

Sood D, Kumar N, Singh A, Sakharkar , Tomar V, Chandra R

Fluoroquinolone (FQ) antibiotics are an important class of synthetic antibacterial agents. These are the most extensively used drugs for treating bacterial infections in the field of both human and veterinary...
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Identification of microbiome with 16S rRNA gene pyrosequencing and antimicrobial effect of egg white in bovine mastitis

Kim D, Kim EK, Seong WJ, Ro Y, Ko DS, Kim NH, Kim JH, Kwon HJ

Bovine mastitis is an important microbial disease in the dairy industry. We investigated the frequencies of bacterial pathogens in 62 farms and pathogen antibiotic resistance from mastitis samples (n =...
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Antimicrobial Susceptibility and Clonal Distribution of the Blood Isolates of Pseudomonas aeruginosa from Two Korean Hospitals

Kim CH, Lee JC

An increasing prevalence of infections caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) causes a serious therapeutic problem in clinical setting. This study investigated the antimicrobial susceptibility, resistance mechanisms against...
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Magnetic nanoparticle based purification and enzyme-linked immunosorbent assay using monoclonal antibody against enrofloxacin

Kim NG, Kim MA, Park YI, Jung TS, Son SW, So B, Kang HG

Monoclonal anti-enrofloxacin antibody was prepared for a direct competitive enzyme-linked immunosorbent assay (ELISA) and purification system using monoclonal antibody (mAb) coupled magnetic nanoparticles (MNPs). The IC50 values of the developed...
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Efflux-mediated resistance identified among norfloxacin resistant clinical strains of group B Streptococcus from South Korea

Dang TN, Srinivasan U, Britt Z, Marrs CF, Zhang L, Ki M, Foxman B

OBJECTIVES: Group B Streptococcus (GBS), a common bowel commensal, is a major cause of neonatal sepsis and an emerging cause of infection in immune-compromised adult populations. Fluoroquinolones are used to...
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Antimicrobial Resistance Pattern in Enterococcus faecalis Strains Isolated From Expressed Prostatic Secretions of Patients With Chronic Bacterial Prostatitis

Seo Y, Lee G

  • KMID: 2316006
  • Korean J Urol.
  • 2013 Jul;54(7):477-481.
PURPOSE: Enterococcus faecalis is one of the most common pathogens linked to chronic bacterial prostatitis (CBP). Owing to a limited number of previous studies addressing this topic, we aimed to...
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Ciprofloxacin Resistance in Enterococcus faecalis Strains Isolated From Male Patients With Complicated Urinary Tract Infection

Lee G

  • KMID: 2316017
  • Korean J Urol.
  • 2013 Jun;54(6):388-393.
PURPOSE: Urinary tract infection (UTI) is one of the most prevalent bacterial infections, and fluoroquinolone therapy is a well-known standard regimen for UTI. The prevalence and risk factor analysis of...
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Biphasic anaphylaxis to gemifloxacin

Yilmaz I, Doğan S, Tutar N, Kanbay A, Büyükoğlan H, Demir R

Anaphylaxis have been documented as adverse effects of ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and moxifloxacin. However resistant and biphasic anaphlylactic reactions to gemifloxacin have not been reported to date. Management of...
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Mutations in gyrA and parC Genes and Plasmid-Mediated Quinolone Resistance in Non-typhoid Salmonella Isolated from Pediatric Patients with Diarrhea in Seoul

Jin YH, Jung JH, Jeon SJ, Lee JK, Oh YH, Choi SM, Chae YZ

A total of 91 non-typhoid Salmonella isolated from pediatric patients with diarrhea in Seoul from 2003 to 2009 was tested for antimicrobial susceptibility of nalidixic acid (NA). Forty strains of...
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Comparison of Methicillin-Sensitive Staphylococcus Epidermidis (MSSE) Keratits and Methicillin-Resistant Staphylococcus Epidermidis (MRSE) Keratitis

Jeong JG, Kweon EY, Cho NC, You IC

PURPOSE: To investigate the clinical features and treatment outcomes between methicillin-sensitive Staphylococcus epidermidis (MSSE) and methicillin-resistant Staphylococcus epidermidis (MRSE) keratitis groups. METHODS: A retrospective analysis of case series was conducted of...
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Serovars distribution and antimicrobial resistance patterns of Salmonella spp. isolated from the swine farms and slaughter houses

Jung H, Lee S, Kim C, Sunwoo S, Lyoo YS

  • KMID: 1446204
  • Korean J Vet Res.
  • 2011 Jun;51(2):123-128.
Salmonella spp. is an important pathogen to both public and swine industry. The aim of this study was to investigate the distribution of Salmonella serovar and antibiotics susceptibility of the...
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Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits

Pavithra B, Prakash N, Jayakumar

Investigation was carried out in adult New Zealand white rabbits to study the influence of curcumin pre-treatment on pharmacokinetic disposition of norfloxacin following single oral administration. Sixteen rabbits were divided...
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Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs

Chang ZQ, Oh BC, Kim JC, Jeong KS, Lee MH, Yun HI, Hwang MH, Park SC

The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight....
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Alteration in gyrA and parC Gene Associated with Fluoroquinolone Resistance of Enterococcus spp. Isolated from Feces of Chicken

Cho JK, Kim KS, Lee YJ, Park CK, Kwak DM, Kim AR, Kang MS, Kim JW, Kim BH, Ku BK

The purpose of this study was to investigate the fluoroquinolone resistance frequency of Enterococcus spp. from normal chicken feces and to analyse mutations of the gyrA and parC gene associated...
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Molecular Epidemiology of Nalidixic Acid Resistance in Shigella sonnei Isolates

Seol SY, Do YK, Jeong YS, Kang HY, Lee JC, Lee YC, Cho DT, Jung TH

  • KMID: 2168478
  • J Bacteriol Virol.
  • 2005 Mar;35(1):23-30.
Twenty-six nalidixic acid-resistant Shigella sonnei strains isolated from 1982 to 2001 and 56 nalidixic acid-resistant mutants induced by quinolone drugs from susceptible wild strains were analyzed by sequencing the gyrA...
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Norfloxacin Hydrogel Coated Urethral Catheters for Prevention of Catheter Associated Urinary Tract Infection in the Rabbit

Kim DI, Lee SJ, Cho YH

  • KMID: 2292263
  • Korean J Urol.
  • 2002 Nov;43(11):980-986.
PURPOSE: We developed a norfloxacin hydrogel coated urethral catheters, and evaluated its efficacy in a rabbit model. Our goal was to create a catheter that would prevent the development of...
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A Case of Drug Eruption Caused by Quinolones

Kim KH, Lew W

  • KMID: 2250967
  • Korean J Dermatol.
  • 2001 Dec;39(12):1440-1442.
The drug eruptions caused by quinolones are rarely reported. The patient took norfloxacin for several days prior to admission and was admitted due to systemic erythematous maculopapular eruptions. For the...
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Antibacterial Activity of Water Soluble Components of Elfvingia applanata Alone and in Combinations with Quinolones

Kim YS, Eo SK, Oh KW, Lee CK, Lee YN, Han SS

  • KMID: 2312336
  • Mycobiology.
  • 2001 Mar;29(1):11-14.
A preparation of water soluble components(EA) was made from carpophores of Elfvingia applanata(Pers.) Karst and its in vitro antibacterial activity on a number of bacterial species was examined by macrobroth...
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Biochemical, Serological and Virulence-associated Characteristics of Yersinia enterocolitica Isolated in Korea

Park JY, Park YH, Yoo HS

  • KMID: 2248701
  • Korean J Infect Dis.
  • 2000 Jun;32(3):186-196.
BACKGROUND: Yersinia enterocolitica is an inhabitant in lower intestinal tract of many domestic and wild animals as well as in nature. Of the several forms of diseases by Y. enterocolitica,...
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Mutation of gyrA in Quinolone-Resistant Clinical Isolates of Escherichia coli

Seol SY, Lee YC, Chang HK

  • KMID: 1943425
  • J Korean Soc Microbiol.
  • 1999 Apr;34(2):103-113.
To study the gyrA mutations of E. coli from clinical specimens, 410 strains were isolated from 1994 to 1997 in Kyungpook National Vniversity hospital. Antimicrobial susceptibility tests, PCR and sequencing...
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