Mycobiology.  2001 Mar;29(1):11-14.

Antibacterial Activity of Water Soluble Components of Elfvingia applanata Alone and in Combinations with Quinolones

• Kim YS
• Eo SK
• Oh KW
• Lee CK
• Lee YN
• Han SS

Abstract

A preparation of water soluble components(EA) was made from carpophores of Elfvingia applanata(Pers.) Karst and its in vitro antibacterial activity on a number of bacterial species was examined by macrobroth dilution assay. Among 16 species of bacteria tested, the most potent antibacterial activity was observed against Staphylococcus epiderrnidis and Proteus vulgaris, of which MICs were 1.25 mg/ml. To investigate the antibacterial effects in combinations of EA with quinolone antibiotics, such as ciprofloxacin, enoxacin, lomefloxacin, norfloxacin, and ofloxacin, the fractional inhibitory concentrations(FICs) and the fractional inhibitory concentration indices(FICIs) for four bacterial strains were determined by macrobroth dilution checkerboard assay. Combinations of EA and quinolones exhibited either additive or indifferent effects of antibacterial activity in most instances. However, both synergistic and antagonistic effects were not observed in any cases.

Keyword

Elfvingia applanata; Macrobroth dilution checkerboard assay; Minimal inhibitory concentration(MIC); Fractional inhibitory concentration(FIC); Fractional inhibitory concentration index(FICI)

MeSH Terms

Anti-Bacterial Agents
Bacteria
Ciprofloxacin
Enoxacin
Norfloxacin
Ofloxacin
Proteus vulgaris
Quinolones*
Staphylococcus
Anti-Bacterial Agents
Ciprofloxacin
Enoxacin
Norfloxacin
Ofloxacin
Quinolones