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p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line

Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J

  • KMID: 1115940
  • Exp Mol Med.
  • 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known...
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Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma

Laks DR, Visnyei K, Kornblum H

At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem...
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Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells

Ishii H, Doki Y, Mori M

Although the notion that cancer is a disease caused by genetic and epigenetic alterations is now widely accepted, perhaps more emphasis has been given to the fact that cancer is...
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Clinicopathological Significance of Maspin Expression in Breast Cancer

Lee MJ, Suh CH, Li ZH

Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated...
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The function of p27(KIP1) during tumor development

Lee J, Kim SS

Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which...
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Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells

Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, Yook JI

  • KMID: 1089447
  • Exp Mol Med.
  • 2005 Oct;37(5):379-390.
Since genetic abnormalities of human cancer are greatly geographically dependent, cultural and environmental backgrounds are thought to be closely related to the carcinogenic process. In the present study, eight human...
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IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1

Yu SJ, Kim HS, Cho SW, Sohn J

  • KMID: 1094082
  • Exp Mol Med.
  • 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the...
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Induction of steroid sulfatase expression by tumor necrosis factor-alpha through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells

Suh BY, Jung JJ, Park N, Seong CH, Im HJ, Kwon Y, Kim D, Chun YJ

Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and has a pivotal role in regulating the formation of biologically active estrogens. STS may be...
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DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells

Sung HY, Ju W, Ahn JH

PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads...
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Comparison of Her-2, EGFR and Cyclin D1 in Primary Breast Cancer and Paired Metastatic Lymph Nodes: An Immunohistochemical and Chromogenic In Situ Hybridization Study

Cho EY, Han JJ, Choi YL, Kim KM, Oh YL

The significant advance in the development of molecular-targeting drugs has made an evaluation of Her-2, EGFR, and cyclin D1 an important clinical issue in breast cancer patients. This study compared...
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Altered p53 expression in Epstein Barr virus positive T cell lymphomas

Lee JH, Lee SS, Park JS, Lee S, Yang MH, Yoon TY

Recent studies have suggested a probable association between Epstein-Barr virus (EBV) and nasal/nasopharyngeal T cell lymphomas but the role of oncogenes or tumor suppressor genes is poorly understood. We have...
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Prognostic Significance of p21 and p53 Expression in Gastric Cancer

Seo YH, Joo YE, Choi SK, Rew JS, Park CS, Kim SJ

  • KMID: 1106143
  • Korean J Intern Med.
  • 2003 Jun;18(2):98-103.
BACKGROUND: Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of...
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Characterization of a brain tumor cell line established from transgenic mice expressing the vasopressin SV-40 T antigen

Kim SH, Kim MO, Lee SR, Kim KS, Lee TH, Lee HT, Ha JH, Kim TY, Ryoo ZY

  • KMID: 1094144
  • Exp Mol Med.
  • 2006 Jun;38(3):196-202.
We previously reported that transgenic mice produced with a transgene consisting of the SV40 T antigen and vasopressin without the 3'-flanking region exhibit brain tumors and lymphoma. In this study,...
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Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells

Jeon YJ, Kim YS

BACKGROUND/AIMS: Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. METHODS: Huh7 cells were...
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Hepatitis C virus and hepatocarcinogenesis

Jeong SW, Jang JY, Chung RT

Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The...
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The biological complexity of RKIP signaling in human cancers

Farooqi AA, Li Y, Sarkar FH

The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have...
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Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma

Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH

  • KMID: 756074
  • Exp Mol Med.
  • 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment...
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Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma

Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES

BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such...
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beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I

An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene....
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Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells

Sung HY, Park AK, Ju W, Ahn JH

PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are...
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