- p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line
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Jiang A, Yu C, Zhang P, Chen W, Liu W, Hu X, Zhang J
- KMID: 1115940
- Exp Mol Med.
- 2006 Dec;38(6):625-633.
Prostate cancer is a disease involving complicated multiple-gene alterations. Both NKX3.1 and p53 are related to prostate cancer and play crucial roles in prostate cancer progression. However, little is known... -
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- Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
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Laks DR, Visnyei K, Kornblum H
- KMID: 1071412
- Yonsei Med J.
- 2010 Sep;51(5):633-640.
- doi: 10.3349/ymj.2010.51.5.633
At this time, brain tumor stem cells remain a controversial hypothesis while malignant brain tumors continue to present a dire prognosis of severe morbidity and mortality. Yet, brain tumor stem... -
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- Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells
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Ishii H, Doki Y, Mori M
- KMID: 1071410
- Yonsei Med J.
- 2010 Sep;51(5):617-621.
- doi: 10.3349/ymj.2010.51.5.617
Although the notion that cancer is a disease caused by genetic and epigenetic alterations is now widely accepted, perhaps more emphasis has been given to the fact that cancer is... -
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- Clinicopathological Significance of Maspin Expression in Breast Cancer
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Lee MJ, Suh CH, Li ZH
- KMID: 1781841
- J Korean Med Sci.
- 2006 Apr;21(2):309-314.
- doi: 10.3346/jkms.2006.21.2.309
Maspin is a unique serine proteinase inhibitor that has tumor suppressor activity. It has been reported that maspin is expressed in normal human mammary epithelial cells and it is down-regulated... -
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- The function of p27(KIP1) during tumor development
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Lee J, Kim SS
- KMID: 1122277
- Exp Mol Med.
- 2009 Nov;41(11):765-771.
- doi: 10.3858/emm.2009.41.11.102
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitors (CKIs) which... -
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- Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells
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Lee EJ, Kim J, Lee SA, Kim EJ, Chun YC, Ryu MH, Yook JI
- KMID: 1089447
- Exp Mol Med.
- 2005 Oct;37(5):379-390.
Since genetic abnormalities of human cancer are greatly geographically dependent, cultural and environmental backgrounds are thought to be closely related to the carcinogenic process. In the present study, eight human... -
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- IL-4 inhibits proliferation of renal carcinoma cells by increasing the expression of p21WAF1 and IRF-1
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Yu SJ, Kim HS, Cho SW, Sohn J
- KMID: 1094082
- Exp Mol Med.
- 2004 Aug;36(4):372-379.
Interleukin (IL)-4 inhibits proliferation of several human cancer cell lines in vitro. Although IL-4 is known to regulate proliferation of lymphocytes by modulating p27KIP1 expression, the mechanism involved in the... -
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- Induction of steroid sulfatase expression by tumor necrosis factor-alpha through phosphatidylinositol 3-kinase/Akt signaling pathway in PC-3 human prostate cancer cells
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Suh BY, Jung JJ, Park N, Seong CH, Im HJ, Kwon Y, Kim D, Chun YJ
- KMID: 1025168
- Exp Mol Med.
- 2011 Nov;43(11):646-652.
- doi: 10.3858/emm.2011.43.11.073
Steroid sulfatase (STS) is responsible for the hydrolysis of aryl and alkyl steroid sulfates and has a pivotal role in regulating the formation of biologically active estrogens. STS may be... -
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- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- Comparison of Her-2, EGFR and Cyclin D1 in Primary Breast Cancer and Paired Metastatic Lymph Nodes: An Immunohistochemical and Chromogenic In Situ Hybridization Study
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Cho EY, Han JJ, Choi YL, Kim KM, Oh YL
- KMID: 1107533
- J Korean Med Sci.
- 2008 Dec;23(6):1053-1061.
- doi: 10.3346/jkms.2008.23.6.1053
The significant advance in the development of molecular-targeting drugs has made an evaluation of Her-2, EGFR, and cyclin D1 an important clinical issue in breast cancer patients. This study compared... -
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- Altered p53 expression in Epstein Barr virus positive T cell lymphomas
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Lee JH, Lee SS, Park JS, Lee S, Yang MH, Yoon TY
- KMID: 927170
- J Korean Med Sci.
- 1995 Dec;10(6):399-405.
- doi: 10.3346/jkms.1995.10.6.399
Recent studies have suggested a probable association between Epstein-Barr virus (EBV) and nasal/nasopharyngeal T cell lymphomas but the role of oncogenes or tumor suppressor genes is poorly understood. We have... -
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- Prognostic Significance of p21 and p53 Expression in Gastric Cancer
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Seo YH, Joo YE, Choi SK, Rew JS, Park CS, Kim SJ
- KMID: 1106143
- Korean J Intern Med.
- 2003 Jun;18(2):98-103.
BACKGROUND: Cyclin-dependent kinase inhibitors (CDKI), including p21, p27 and p57 of the KIP family, are negative regulators of cell cycle progression and potentially act as tumor suppressors. The expression of... -
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- Characterization of a brain tumor cell line established from transgenic mice expressing the vasopressin SV-40 T antigen
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Kim SH, Kim MO, Lee SR, Kim KS, Lee TH, Lee HT, Ha JH, Kim TY, Ryoo ZY
- KMID: 1094144
- Exp Mol Med.
- 2006 Jun;38(3):196-202.
We previously reported that transgenic mice produced with a transgene consisting of the SV40 T antigen and vasopressin without the 3'-flanking region exhibit brain tumors and lymphoma. In this study,... -
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- Cyclosporin A Inhibits Albumin Synthesis in Huh7 Cells
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Jeon YJ, Kim YS
- KMID: 1022171
- Korean J Intern Med.
- 2011 Sep;26(3):314-319.
- doi: 10.3904/kjim.2011.26.3.314
BACKGROUND/AIMS: Hypoalbuminemia occurs frequently in renal transplant recipients immediately after renal transplantation. We studied the regulation of hepatic albumin synthesis by cyclosporin A (CsA) in Huh7 cells. METHODS: Huh7 cells were... -
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- Hepatitis C virus and hepatocarcinogenesis
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Jeong SW, Jang JY, Chung RT
- KMID: 1410890
- Clin Mol Hepatol.
- 2012 Dec;18(4):347-356.
- doi: 10.3350/cmh.2012.18.4.347
Hepatitis C virus (HCV) is an RNA virus that is unable to integrate into the host genome. However, its proteins interact with various host proteins and induce host responses. The... -
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- The biological complexity of RKIP signaling in human cancers
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Farooqi AA, Li Y, Sarkar FH
- KMID: 2155439
- Exp Mol Med.
- 2015 Sep;47(9):e185.
- doi: 10.1038/emm.2015.70
The Raf kinase inhibitory protein (RKIP) has been demonstrated to modulate different intracellular signaling pathways in cancers. Studies have shown that RKIP is frequently downregulated in cancers; therefore, attempts have... -
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- Mutation analysis of p31(comet) gene, a negative regulator of Mad2, in human hepatocellular carcinoma
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Yun MY, Kim SB, Park S, Han CJ, Han YH, Yoon SH, Kim SH, Kim CM, Choi DW, Cho MH, Park GH, Lee KH
- KMID: 756074
- Exp Mol Med.
- 2007 Aug;39(4):508-513.
Failure of mitotic checkpoint machinery leads to the chromosomal missegregation and nuclear endoreduplication, thereby driving the emergence of aneuploidy and tetraploidy population. Although abnormal nuclear ploidy and the resulting impairment... -
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- Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma
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Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES
- KMID: 1775922
- Korean J Gastroenterol.
- 2010 Jan;55(1):19-25.
- doi: 10.4166/kjg.2010.55.1.19
BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such... -
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- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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- Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells
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Sung HY, Park AK, Ju W, Ahn JH
- KMID: 1799482
- Yonsei Med J.
- 2014 Sep;55(5):1206-1213.
- doi: 10.3349/ymj.2014.55.5.1206
PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are... -
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