- Therapeutic Approaches for Inhibition of Protein Aggregation in Huntington's Disease
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Kim S, Kim KT
- KMID: 2009023
- Exp Neurobiol.
- 2014 Mar;23(1):36-44.
- doi: 10.5607/en.2014.23.1.36
Huntington's disease (HD) is a late-onset and progressive neurodegenerative disorder that is caused by aggregation of mutant huntingtin protein which contains expanded-polyglutamine. The molecular chaperones modulate the aggregation in early... -
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- Heat Shock Proteins as Molecular Chaperons in Neuropsychiatry
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Oh DH, Yang BH, Choi J
- KMID: 2249323
- Korean J Biol Psychiatry.
- 2007 Nov;14(4):221-231.
Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage... -
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- Screening Molecular Chaperones Similar to Small Heat Shock Proteins in Schizosaccharomyces pombe
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Han J, Kim K, Lee S
- KMID: 2312823
- Mycobiology.
- 2015 Sep;43(3):272-279.
- doi: 10.5941/MYCO.2015.43.3.272
To screen molecular chaperones similar to small heat shock proteins (sHsps), but without alpha-crystalline domain, heat-stable proteins from Schizosaccharomyces pombe were analyzed by 2-dimensional electrophoresis and matrix assisted laser desorption/ionization... -
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- Bioinformatics Analysis of Hsp20 Sequences in Proteobacteria
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Heine M, Chandra SB
- KMID: 2166438
- Genomics Inform.
- 2009 Mar;7(1):26-31.
Heat shock proteins are a class of molecular chaperones that can be found in nearly all organisms from Bacteria, Archaea and Eukarya domains. Heat shock proteins experience increased transcription during... -
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- The immune modulating properties of the heat shock proteins after brain injury
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Kim JY, Yenari MA
- KMID: 2046752
- Anat Cell Biol.
- 2013 Mar;46(1):1-7.
- doi: 10.5115/acb.2013.46.1.1
Inflammation within the central nervous system often accompanies ischemia, trauma, infection, and other neuronal injuries. The immune system is now recognized to play a major role in neuronal cell death... -
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- Age-related decline in expression of calnexin
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Choi BH, Kim JS
- KMID: 1123772
- Exp Mol Med.
- 2004 Oct;36(5):499-503.
Aging is accompanied by the changes in the cells that decrease their capacity to respond to various forms of stress. Cells are known to respond to stresses through expression of... -
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- Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family
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Cheong K, Choi J, Choi J, Park J, Jang S, Lee YH
- KMID: 1806271
- Genomics Inform.
- 2013 Mar;11(1):52-54.
- doi: 10.5808/GI.2013.11.1.52
Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A... -
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- Heat Shock Protein as Molecular Targets for Breast Cancer Therapeutics
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Kim LS, Kim JH
- KMID: 2394768
- J Breast Cancer.
- 2011 Sep;14(3):167-174.
Recent advances in the understanding of the molecular mechanisms involved in the breast cancer development and progression have led to the identification of numerous novel molecular targets. Among these, heat... -
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- The Roles of Clusterin on Morphogenesis of Beta Cells During Pancreas Regeneration
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Hong SW, Ranjan K, Lee S, Shin YJ, Min BH, Park IS
- KMID: 2008091
- J Korean Diabetes Assoc.
- 2007 Jan;31(1):1-8.
- doi: 10.4093/jkda.2007.31.1.1
Clusterin is a highly glycosylated heterodimeric glycoprotein that plays diverse biological roles in various organs. The secreted clusterin has been established as a major form of the protein that exerts... -
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- Amyloidogenic Protein of alpha-Synuclein
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Yang JE, Paik SR
- KMID: 2168245
- Hanyang Med Rev.
- 2013 May;33(2):123-129.
- doi: 10.7599/hmr.2013.33.2.123
Amyloidogenesis is the key pathological phenomenon commonly observed in various neurodegenerative disorders. alpha-Synuclein is the major constituent of Lewy bodies as a common pathological signature of Lewy body diseases (LBDs)... -
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- Characterization of an Extracytoplasmic Chaperone Spy in Protecting Salmonella against Reactive Oxygen/Nitrogen Species
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Park YM, Lee HJ, Bang IS
- KMID: 2170789
- Int J Oral Biol.
- 2014 Dec;39(4):207-213.
- doi: 10.11620/IJOB.2014.39.4.207
Antimicrobial actions of reactive oxygen/nitrogen species (ROS/RNS) derived from products of NADPH oxidase and inducible nitric oxide (NO) synthase in host phagocytes inactivate various bacterial macromolecules. To cope with these... -
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- The Role of Heat Shock Proteins 70/90 as Potential Molecular Therapeutic Targets in Breast Cancer
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Kang HJ, Hong MK, Jung SK, Kim LS
- KMID: 2286590
- J Breast Cancer.
- 2007 Dec;10(4):231-240.
- doi: 10.4048/jbc.2007.10.4.231
PURPOSE: Heat shock proteins (hsps) are molecular chaperones that are synthesized by cells in response to various stress conditions. The expression of hsps have been shown to be associated with... -
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- Roles of ERK and NF-kappa B in Interleukin-8 Expression in Response to Heat Shock Protein 22 in Vascular Smooth Muscle Cells
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Kang SH, Lee JH, Choi KH, Rhim BY, Kim K
- KMID: 1838355
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):171-176.
- doi: 10.4196/kjpp.2008.12.4.171
Heat shock proteins (HSPs) serve as molecular chaperones and play a role in cell protection from damage in response to stress stimuli. The aim of this article is to investigate... -
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- Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1
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Graham RM, Hernandez , Puerta N, De Angulo , Webster KA, Vanni S
- KMID: 2361497
- Exp Mol Med.
- 2016 Feb;48(2):e210.
- doi: 10.1038/emm.2015.116
Cancer cells typically display increased rates of aerobic glycolysis that are correlated with tumor aggressiveness and a poor prognosis. Targeting the glycolytic pathway has emerged as an attractive therapeutic route... -
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- Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
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Park S, Park JA, Jeon JH, Lee Y
- KMID: 2456216
- Biomol Ther.
- 2019 Sep;27(5):423-434.
- doi: 10.4062/biomolther.2019.051
HSP90 is a molecular chaperone that increases the stability of client proteins. Cancer cells show higher HSP90 expression than normal cells because many client proteins play an important role in... -
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- The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression
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Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC
- KMID: 2380345
- Biomol Ther.
- 2015 Mar;23(2):128-133.
- doi: 10.4062/biomolther.2014.133
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins... -
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- Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment
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Shin DI, Oh YJ
- KMID: 2009026
- Exp Neurobiol.
- 2014 Mar;23(1):65-76.
- doi: 10.5607/en.2014.23.1.65
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Most cases are sporadic and its etiology is incompletely... -
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- Small Molecule Inhibitors to Disrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
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Seo YH
- KMID: 2171313
- J Cancer Prev.
- 2015 Mar;20(1):5-11.
- doi: 10.15430/JCP.2015.20.1.5
Heat shock protein 90 (Hsp90) is an adenosine triphosphate dependent molecular chaperone in eukaryotic cells that regulates the activation and maintenance of numerous regulatory and signaling proteins including epidermal growth... -
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- Expression of HSP27 and alphaB-crystallin in Avian Cerebellum during Development
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Seo JH, Moon SW, Sohn HJ
- KMID: 1510219
- Korean J Anat.
- 2006 Dec;39(6):453-460.
It is well known that small heat shock proteins play a role as molecular chaperone. However, during normal development of the cerebellum, expression and distribution of HSP27 and alphaB-crystallin (alphaBC)... -
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- Characterize and Gene Expression of Heat Shock Protein 90 in Marine Crab Charybdis japonica following Bisphenol A and 4-Nonylphenol Exposures
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Park K, Kwak IS
- KMID: 2380095
- Environ Health Toxicol.
- 2014 ;29(1):e2014002.
OBJECTIVES: Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone important in the maturation of a broad spectrum of protein. In this study, an HSP90 gene was isolated... -
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