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Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs

Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH

The inhibitory effect of neutering on mammary gland tumor development in dogs has been well described. However, we observed that the effect of neutering on tumor malignancy may be altered...
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Mammary fibroadenoma in a lamb

Gulbahar M, Guvenc T, Yarim M, Kabak YB, Sozgen Y

A fibroadenoma was diagnosed in the left udder of a 3-month-old female Chios lamb. No recurrence was observed after surgery. Grossly, the tumor had a whitishgray lobular appearance, and the...
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Alpha basic crystallin expression in canine mammary tumors

Guvenc T, Gulbahar M, Yarim M, Kabak YB, Karayigit , Sozmen M

The aim of this study was to evaluate prognostic and/or diagnostic factors of canine mammary tumors by immunohistochemically analyzing the expression of alpha basic crystallin (alphaB-c). For this, formalin-fixed, paraffin-embedded...
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Mutations of p53 Tumor Suppressor Gene in Spontaneous Canine Mammary Tumors

Lee CH, Kweon OK

  • KMID: 1097349
  • J Vet Sci.
  • 2002 Dec;3(4):321-325.
Mutation of the p53 tumor suppressor gene has been related in the pathogenesis of numerous human and canine cancers, including breast cancers and mammary tumors. We have investigated exons 5-8...
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Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells

Byeon JS, Lee J, Jeong DU, Gu NY, Cho IS, Cha SH

Canine mammary tumors are among the most frequently observed cutaneous tumors in female dogs. Cancer stem cells (CSCs), referred to as tumor-initiating cells, are thought to have properties similar to...
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Recurrent Malignant Phyllodes Tumor with Liposarcoma

Lee JS, Kim HS, Jung JJ, Cho CD

  • KMID: 2275599
  • Korean J Pathol.
  • 2001 Dec;35(6):558-560.
Phyllodes tumors are an uncommon mammary tumors composed of benign epithelial elements and cellular, spindle cell stroma. Adipose differentiation is an uncommon stromal alteration in phyllodes tumors. Herein, a case...
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Establishment of a canine mammary gland tumor cell line and characterization of its miRNA expression

Osaki T, Sunden Y, Sugiyama A, Azuma K, Murahata Y, Tsuka T, Ito N, Imagawa T, Okamoto Y

Canine mammary gland tumors (CMGTs), which are the most common neoplasms in sexually intact female dogs, have been suggested as a model for studying human breast cancer because of several...
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The potential role of COX-2 in cancer stem cell-mediated canine mammary tumor initiation: an immunohistochemical study

Huang J, Zhang D, Xie F, Lin D

Increasing evidence suggests that cancer stem cells (CSCs) are responsible for tumor initiation and maintenance. Additionally, it is becoming apparent that cyclooxygenase (COX) signaling is associated with canine mammary tumor...
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Osteogenic Sarcoma of the Breast

Ryu BY, Kim TH, Kim HS, Hwang DJ, Cho JW, Lee HW, Kim HK, Seok H, Choi YH

  • KMID: 2145200
  • J Korean Surg Soc.
  • 2001 Oct;61(4):441-444.
Osteogenic sarcoma is a rare breast tumor. The first report of a malignant mammary neoplasm composed of bone and cartilage was that of Bonet in 1700. Meanwhile in Korea, Kim...
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Mutation and overexpression of p53 as a prognostic factor in canine mammary tumors

Lee CH, Kim WH, Lim JH, Kang MS, Kim DY, Kweon OK

  • KMID: 1094689
  • J Vet Sci.
  • 2004 Mar;5(1):63-69.
We concentrated ourselves to evaluate the prognostic significance of the p53 gene mutations, its protein expression and MIB-1 index as a proliferative marker in canine mammary tumors. In the present...
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Stage-specific embryonic antigen: determining expression in canine glioblastoma, melanoma, and mammary cancer cells

Lin W, Modiano JF, Ito D

The expression of stage-specific embryonic antigens (SSEAs) was determined in several types of canine cancer cells. Flow cytometry showed SSEA-1 expression in glioblastoma, melanoma, and mammary cancer cells, although none...
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Tarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas

Gultiken N, Guvenc T, Kaya D, Agaoglu AR, Ay SS, Kucukaslan I, Emre B, Findik M, Schafer-Somi S, Aslan S

In the present study, 13 clinical cases of canine mammary adenocarcinoma were evaluated in order to understand the effect of Tarantula cubensis extract (TCE) on tumor tissue. Punch biopsies were...
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Spectrum of Axillary Disorders (Excluding Metastasis from Breast Cancer): Radiological and Pathological Correlation: A Pictorial Essay

Kim HJ, Kim KW, Park YS, Chung DJ, Cho YJ, Hwang CM, Yoo HM, Kim YM, Lee MR

Axillary disorders originate from an axillary lymph node, subcutaneous fat layer, accessory breast, nerve, vessel and muscle. The most common causes of a palpable axillary mass are a lymph node...
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The Fine Needle Aspiration Cytologic Features of Apocrine Carcinoma of the Breast: A Case Report

Eom M, Park JK, Jung SH, Lee KG

  • KMID: 1619637
  • Korean J Cytopathol.
  • 2003 Nov;14(2):76-81.
Apocrine carcinoma of the breast is a very rare subtype. Although it has no clinical differences from usual ductal carcinoma of the breast, it should be categorized as a subtype...
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Estrogen receptor-α, progesterone receptor, and c-erbB/HER-family receptor mRNA detection and phenotype analysis in spontaneous canine models of breast cancer

Kabir FM, DeInnocentes P, Agarwal P, Mill CP, Riese DJ, Bird RC

Well characterized, stable, p16-defective canine mammary cancer (CMT) cell lines and normal canine mammary epithelial cells were used to investigate expression of the major breast cancer-specific hormone receptors estrogen receptor...
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Evaluation of expression of the Wnt signaling components in canine mammary tumors via RT² Profiler PCR Array and immunochemistry assays

Yu F, Rasotto R, Zhang H, Pei S, Zhou B, Yang X, Jin Y, Zhang D, Lin D

The Wnt signaling pathway and its key component β-catenin have critical roles in the development of diseases such as tumors in mammals. However, little has been reported about involvement of...
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HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization and Immunohistochemical Expression of Topoisomerase II-alpha in the Breast Cancer

Lee TJ, Oh HG, Kwon GY, Kim MK, Park ES, Yoo JH

  • KMID: 1725953
  • Korean J Pathol.
  • 2003 Feb;37(1):26-34.
BACKGROUND: Amplifications of the HER-2/neu oncogene and the Topoisomerase II-alpha gene are important determiners of the response to chemotherapy in the breast cancer. For detecting HER-2/neu amplification, fluorescent in situ...
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Usefulness of Frozen Section Examination of Core Needle Biopsy in the Breast Carcinoma

Kim YJ, Chun YK, Hong SR, Kim HS, Kang SS, Lee JH, Lee SK, Kim HS

  • KMID: 1979381
  • Korean J Pathol.
  • 2002 Jun;36(3):163-166.
BACKGROUND: Core needle biopsy (CNB) is widely used as the initial sampling method for breast cancer. And because frozen section (FS) diagnosis is rapid and reliable, we studied the diagnostic...
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Mucinous Carcinoma of the Breast in Comparison with Invasive Ductal Carcinoma: Clinicopathologic Characteristics and Prognosis

Bae SY, Choi MY, Cho DH, Lee JE, Nam SJ, Yang JH

PURPOSE: Mucinous carcinoma (MC) of the breast is a rare histologic type of mammary neoplasm. The objective of this study was to evaluate the long-term disease-free survival (DFS) and overall...
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