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Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population

Kim DK, Kim JY, Han YE, Kim JK, Lim HS, Eun KM, Yang SK, Kim DW

PURPOSE: Various immune cells, including eosinophils and neutrophils, are known to contribute to the development of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the current understanding of the role of...
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Terminally Differentiating Eosinophils Express Neutrophil Primary Granule Proteins as well as Eosinophil-specific Granule Proteins in a Temporal Manner

Kim K, Hwang SM, Kim SM, Park SW, Jung Y, Chung IY

Neutrophils and eosinophils, 2 prominent granulocytes, are commonly derived from myelocytic progenitors through successive stages in the bone marrow. Our previous genome-wide transcriptomic data unexpectedly showed that genes encoding a...
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Current insights into inherited bone marrow failure syndromes

Chung NG, Kim M

  • KMID: 2353160
  • Korean J Pediatr.
  • 2014 Aug;57(8):337-344.
Inherited bone marrow failure syndrome (IBMFS) encompasses a heterogeneous and complex group of genetic disorders characterized by physical malformations, insufficient blood cell production, and increased risk of malignancies. They often...
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Different Clinical Phenotypes in Familial Severe Congenital Neutropenia Cases with Same Mutation of the ELANE Gene

Cho HK, Jeon IS

Severe congenital neutropenia (SCN) is a heterogeneous group of disorders with a defect in granulopoiesis causing marked neutropenia and severe bacterial infections. A 17-month-old girl (patient 1) was admitted due...
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Adult-onset Cyclic Neutropenia Diagnosed in a Patient with Acute Arthritis

Lee MJ, Yoo JJ, Kang EH, Lee SG, Shin K, Lee EY, Lee EB, Song YW, Lee YJ

Cyclic neutropenia (CN) is a rare disorder characterized by repetitive episodes of neutropenia and is generally associated with fever, oral mucosal ulcers, and bacterial infections in the neutropenic episodes. It...
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Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery

Kim NY, Shim JK, Bang SO, Sim JS, Song JW, Kwak YL

BACKGROUND: Both systemic inflammatory reaction and regional myocardial ischemia/reperfusion injury may elicit hypercoagulability after off-pump coronary artery bypass grafting (OPCAB). We investigated the influence of ulinastatin, which suppresses the activity...
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Novel ELANE Gene Mutation in a Korean Girl with Severe Congenital Neutropenia

Shim YJ, Kim HJ, Suh JS, Lee KS

Severe congenital neutropenia is a heterozygous group of bone marrow failure syndromes that cause lifelong infections. Mutation of the ELANE gene encoding human neutrophil elastase is the most common genetic...
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Simvastatin as a Modulator of Tissue Remodeling through Inhibition of Matrix Metalloproteinase (MMP) Release from Human Lung Fibroblasts

Ra JE, Lee JK, Kim HJ

  • KMID: 2319550
  • Tuberc Respir Dis.
  • 2011 Sep;71(3):172-179.
BACKGROUND: Statins can regulate the production of pro-inflammatory cytokines and inhibit MMP production or activation in a variety of types of cells. This study evaluated whether statins would inhibit MMP...
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Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells

Jiang DP, Perelman J, Kolosov VP, Zhou XD

Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial...
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Changes of Alpha1-Antitrypsin Levels in Allergen-induced Nasal Inflammation

Shin SY, Choi GS, Lee KH, Kim SW, Won KY, Lee JH, Cho JS, Park HS

  • KMID: 2166459
  • Clin Exp Otorhinolaryngol.
  • 2011 Mar;4(1):33-39.
OBJECTIVES: Alpha1-antitrypsin (AAT) is the main inhibitor of human neutrophil elastase, and plays a role in counteracting the tissue damage caused by elastase in local inflammatory conditions. The study evaluated...
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Effect of ulinastatin on cytokine reaction during gastrectomy

Park JH, Kwak SH, Jeong CW, Bae HB, Kim SJ

BACKGROUND: Inflammation plays an important role in the postoperative morbidity of organs, which is related to the activation of pro-inflammatory and anti-inflammatory cytokines. Ulinastatin (Urinary trypsin inhibitor, UTI) is a...
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Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients

Joo SY, Kim JE, Kim JY, Han KS, Kim HK

BACKGROUND: Disseminated intravascular coagulation (DIC) is characterized by platelet and neutrophil activation. Platelets are the major source of circulating vascular endothelial growth factor (VEGF). Endostatin, an anti-angiogenic factor, is a...
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The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock

Park KH, Lee KH, Kim H, Hwang SO

We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and its effects on the...
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Effect of the Neutrophil Elastase Inhibitor on Acute Lung Injury after Pulmonary Resection for Lung Cancer: A Preliminary Study

Park SY, Park S, Jeon K, Lim SY, Park MR, Kim S, Song JU, Kim JG, Kwon OJ, Suh GY

BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the leading causes of death after lungresection. Neutrophil elastase is thought to be an important mediator in the...
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The Effect of Human Neutrophil Elastase on the Human Nasal Mucus Secretion

Kim JS

  • KMID: 2074642
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 Jan;50(1):43-47.
BACKGROUD AND OBJECTIVES: Human neutrophil elastase (HNE), secreted from neutrophil, is known to cause mucus hypersecretion in case of airway inflammation. The purpose of this study is to find out...
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Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells

Song JS, Cho KS, Yoon HK, Moon HS, Park SH

BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway...
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Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: sealed cut and exposed tongue wounds

Lee SK, Lee SS, Song IS, Kim YS, Park YW, Joo JY, Um HS, Kim JW, Kim KY, Choi SJ, Jung KH, Chung SI

  • KMID: 1097108
  • Exp Mol Med.
  • 2004 Jun;36(3):259-267.
Innate elastase inhibitors are known to be putatively involved in the regulation of tissue inflammation by inhibiting polymorphonuclear leukocyte (PMN) derived proteinases. The aim of this study was to evaluate...
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The Relationship between Human Neutrophil Elastase and Coronary Arterial Dilatation in Kawasaki Disease

Shim JY, Choi HW, Hong JH, Lee JK, Lee HY

  • KMID: 1607043
  • J Korean Pediatr Soc.
  • 2003 Sep;46(9):903-908.
PURPOSE: Kawasaki disease is notorious for coronary arterial complication which is usually developed as a febrile disease in early childhood. Increased polymorphonucleus(PMN) cell levels in acute phases may be associated...
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Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury

Yum HK

ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,...
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Effect of Neutrophil Elastase inhibitor, ICI 200,355, on Interleukin-1 Induced acute lung injury in rats

Chung JH, Mun YC, Park HJ, Shin KC, Lee KH

BACKGROUND: Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought...
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