- Elastase-Positive Neutrophils Are Associated With Refractoriness of Chronic Rhinosinusitis With Nasal Polyps in an Asian Population
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Kim DK, Kim JY, Han YE, Kim JK, Lim HS, Eun KM, Yang SK, Kim DW
- KMID: 2462571
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):42-55.
- doi: 10.4168/aair.2020.12.1.42
PURPOSE: Various immune cells, including eosinophils and neutrophils, are known to contribute to the development of chronic rhinosinusitis with nasal polyps (CRSwNP). However, the current understanding of the role of... -
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- Terminally Differentiating Eosinophils Express Neutrophil Primary Granule Proteins as well as Eosinophil-specific Granule Proteins in a Temporal Manner
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Kim K, Hwang SM, Kim SM, Park SW, Jung Y, Chung IY
- KMID: 2400627
- Immune Netw.
- 2017 Dec;17(6):410-423.
- doi: 10.4110/in.2017.17.6.410
Neutrophils and eosinophils, 2 prominent granulocytes, are commonly derived from myelocytic progenitors through successive stages in the bone marrow. Our previous genome-wide transcriptomic data unexpectedly showed that genes encoding a... -
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- Current insights into inherited bone marrow failure syndromes
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Chung NG, Kim M
- KMID: 2353160
- Korean J Pediatr.
- 2014 Aug;57(8):337-344.
Inherited bone marrow failure syndrome (IBMFS) encompasses a heterogeneous and complex group of genetic disorders characterized by physical malformations, insufficient blood cell production, and increased risk of malignancies. They often... -
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- Different Clinical Phenotypes in Familial Severe Congenital Neutropenia Cases with Same Mutation of the ELANE Gene
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Cho HK, Jeon IS
- KMID: 1734937
- J Korean Med Sci.
- 2014 Mar;29(3):452-455.
- doi: 10.3346/jkms.2014.29.3.452
Severe congenital neutropenia (SCN) is a heterogeneous group of disorders with a defect in granulopoiesis causing marked neutropenia and severe bacterial infections. A 17-month-old girl (patient 1) was admitted due... -
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- Adult-onset Cyclic Neutropenia Diagnosed in a Patient with Acute Arthritis
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Lee MJ, Yoo JJ, Kang EH, Lee SG, Shin K, Lee EY, Lee EB, Song YW, Lee YJ
- KMID: 2223049
- J Rheum Dis.
- 2013 Feb;20(1):48-51.
- doi: 10.4078/jrd.2013.20.1.48
Cyclic neutropenia (CN) is a rare disorder characterized by repetitive episodes of neutropenia and is generally associated with fever, oral mucosal ulcers, and bacterial infections in the neutropenic episodes. It... -
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- Effects of ulinastatin on coagulation in high-risk patients undergoing off-pump coronary artery bypass graft surgery
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Kim NY, Shim JK, Bang SO, Sim JS, Song JW, Kwak YL
- KMID: 1798221
- Korean J Anesthesiol.
- 2013 Feb;64(2):105-111.
- doi: 10.4097/kjae.2013.64.2.105
BACKGROUND: Both systemic inflammatory reaction and regional myocardial ischemia/reperfusion injury may elicit hypercoagulability after off-pump coronary artery bypass grafting (OPCAB). We investigated the influence of ulinastatin, which suppresses the activity... -
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- Novel ELANE Gene Mutation in a Korean Girl with Severe Congenital Neutropenia
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Shim YJ, Kim HJ, Suh JS, Lee KS
- KMID: 1786025
- J Korean Med Sci.
- 2011 Dec;26(12):1646-1649.
- doi: 10.3346/jkms.2011.26.12.1646
Severe congenital neutropenia is a heterozygous group of bone marrow failure syndromes that cause lifelong infections. Mutation of the ELANE gene encoding human neutrophil elastase is the most common genetic... -
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- Simvastatin as a Modulator of Tissue Remodeling through Inhibition of Matrix Metalloproteinase (MMP) Release from Human Lung Fibroblasts
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Ra JE, Lee JK, Kim HJ
- KMID: 2319550
- Tuberc Respir Dis.
- 2011 Sep;71(3):172-179.
BACKGROUND: Statins can regulate the production of pro-inflammatory cytokines and inhibit MMP production or activation in a variety of types of cells. This study evaluated whether statins would inhibit MMP... -
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- Effects of Scutellarin on MUC5AC Mucin Production Induced by Human Neutrophil Elastase or Interleukin 13 on Airway Epithelial Cells
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Jiang DP, Perelman J, Kolosov VP, Zhou XD
- KMID: 1785964
- J Korean Med Sci.
- 2011 Jun;26(6):778-784.
- doi: 10.3346/jkms.2011.26.6.778
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial... -
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- Changes of Alpha1-Antitrypsin Levels in Allergen-induced Nasal Inflammation
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Shin SY, Choi GS, Lee KH, Kim SW, Won KY, Lee JH, Cho JS, Park HS
- KMID: 2166459
- Clin Exp Otorhinolaryngol.
- 2011 Mar;4(1):33-39.
OBJECTIVES: Alpha1-antitrypsin (AAT) is the main inhibitor of human neutrophil elastase, and plays a role in counteracting the tissue damage caused by elastase in local inflammatory conditions. The study evaluated... -
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- Effect of ulinastatin on cytokine reaction during gastrectomy
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Park JH, Kwak SH, Jeong CW, Bae HB, Kim SJ
- KMID: 2299329
- Korean J Anesthesiol.
- 2010 Apr;58(4):334-337.
- doi: 10.4097/kjae.2010.58.4.334
BACKGROUND: Inflammation plays an important role in the postoperative morbidity of organs, which is related to the activation of pro-inflammatory and anti-inflammatory cytokines. Ulinastatin (Urinary trypsin inhibitor, UTI) is a... -
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- Usefulness of circulating vascular endothelial growth factor and neutrophil elastase as diagnostic markers of disseminated intravascular coagulation in non-cancer patients
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Joo SY, Kim JE, Kim JY, Han KS, Kim HK
- KMID: 2252079
- Korean J Hematol.
- 2010 Mar;45(1):23-28.
- doi: 10.5045/kjh.2010.45.1.23
BACKGROUND: Disseminated intravascular coagulation (DIC) is characterized by platelet and neutrophil activation. Platelets are the major source of circulating vascular endothelial growth factor (VEGF). Endostatin, an anti-angiogenic factor, is a... -
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- The Anti-Inflammatory Effects of Ulinastatin in Trauma Patients with Hemorrhagic Shock
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Park KH, Lee KH, Kim H, Hwang SO
- KMID: 1713843
- J Korean Med Sci.
- 2010 Jan;25(1):128-134.
- doi: 10.3346/jkms.2010.25.1.128
We investigated the use of ulinastatin in association with the suppression of polymorphonuclear leukocyte elastase (PMNE), tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), and its effects on the... -
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- Effect of the Neutrophil Elastase Inhibitor on Acute Lung Injury after Pulmonary Resection for Lung Cancer: A Preliminary Study
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Park SY, Park S, Jeon K, Lim SY, Park MR, Kim S, Song JU, Kim JG, Kwon OJ, Suh GY
- KMID: 2228304
- Korean J Crit Care Med.
- 2009 Dec;24(3):124-128.
- doi: 10.4266/kjccm.2009.24.3.124
BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are the leading causes of death after lungresection. Neutrophil elastase is thought to be an important mediator in the... -
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- The Effect of Human Neutrophil Elastase on the Human Nasal Mucus Secretion
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Kim JS
- KMID: 2074642
- Korean J Otolaryngol-Head Neck Surg.
- 2007 Jan;50(1):43-47.
BACKGROUD AND OBJECTIVES: Human neutrophil elastase (HNE), secreted from neutrophil, is known to cause mucus hypersecretion in case of airway inflammation. The purpose of this study is to find out... -
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- Neutrophil Elastase Causes MUC5AC Mucin Synthesis Via EGF Receptor, ERK and NF-kB Pathways in A549 Cells
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Song JS, Cho KS, Yoon HK, Moon HS, Park SH
- KMID: 1115250
- Korean J Intern Med.
- 2005 Dec;20(4):275-283.
- doi: 10.3904/kjim.2005.20.4.275
BACKGROUND: Neutrophil elastase (NE) was found to increase the respiratory mucin gene, MUC5AC, although the molecular mechanisms of this process remain unknown. We attempted to determine the signal transduction pathway... -
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- Paradoxical effects of elastase inhibitor guamerin on the tissue repair of two different wound models: sealed cut and exposed tongue wounds
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Lee SK, Lee SS, Song IS, Kim YS, Park YW, Joo JY, Um HS, Kim JW, Kim KY, Choi SJ, Jung KH, Chung SI
- KMID: 1097108
- Exp Mol Med.
- 2004 Jun;36(3):259-267.
Innate elastase inhibitors are known to be putatively involved in the regulation of tissue inflammation by inhibiting polymorphonuclear leukocyte (PMN) derived proteinases. The aim of this study was to evaluate... -
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- The Relationship between Human Neutrophil Elastase and Coronary Arterial Dilatation in Kawasaki Disease
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Shim JY, Choi HW, Hong JH, Lee JK, Lee HY
- KMID: 1607043
- J Korean Pediatr Soc.
- 2003 Sep;46(9):903-908.
PURPOSE: Kawasaki disease is notorious for coronary arterial complication which is usually developed as a febrile disease in early childhood. Increased polymorphonucleus(PMN) cell levels in acute phases may be associated... -
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- Molecular Mechanisms of Neutrophil Activation in Acute Lung Injury
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Yum HK
- KMID: 1877035
- Tuberc Respir Dis.
- 2002 Dec;53(6):595-611.
- doi: 10.4046/trd.2002.53.6.595
ABBREVIATIONS: Akt/PKB protein kinase B, ALI acute lung injury, ARDS acute respiratory distress syndrome, CREB C-AMP response element binding protein, ERK extracelluar signal-related kinase, fMLP fMet-Leu-Phe, G-CSF granulocyte colony-stimulating factor,... -
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- Effect of Neutrophil Elastase inhibitor, ICI 200,355, on Interleukin-1 Induced acute lung injury in rats
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Chung JH, Mun YC, Park HJ, Shin KC, Lee KH
- KMID: 1909947
- Yeungnam Univ J Med.
- 2002 Jun;19(1):55-62.
- doi: 10.12701/yujm.2002.19.1.55
BACKGROUND: Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought... -
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