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Expression of deafness protein Tmie in postnatal developmental stages of C57BL/6J mice

Karuppasamy S, Nam Y, Jung H, Suh JG

  • Lab Anim Res.
  • 2012 Jun;28(2):147-150.
  • doi: 10.5625/lar.2012.28.2.147
Loss-of function mutations in the transmembrane inner ear expressed (Tmie/TMIE) gene have been shown to cause deafness in mice and humans (DFNB6). Previous studies report that the circling mouse can...
Monitoring of antibiotic resistance in bacteria isolated from laboratory animals

Goo JS, Jang MK, Shim SB, Jee SW, Lee SH, Bae CJ, Park S, Kim KJ, Kim JE, Hwang IS, Lee HR, Choi SI, Lee YJ, Lim CJ, Hwang DY

  • Lab Anim Res.
  • 2012 Jun;28(2):141-145.
  • doi: 10.5625/lar.2012.28.2.141
The drug resistance of microorganisms isolated from laboratory animals never treated with antibiotics is being reported consistently, while the number of laboratory animals used in medicine, pharmacy, veterinary medicine, agriculture,...
Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model

Kim D, Park D, Kyung J, Yang YH, Choi EK, Lee YB, Kim HK, Hwang BY, Kim YB

  • Lab Anim Res.
  • 2012 Jun;28(2):137-140.
  • doi: 10.5625/lar.2012.28.2.137
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as...
Pain modality and spinal glia expression by streptozotocin induced diabetic peripheral neuropathy in rats

Kim SH, Kwon JK, Kwon YB

  • Lab Anim Res.
  • 2012 Jun;28(2):131-136.
  • doi: 10.5625/lar.2012.28.2.131
Pain symptoms are a common complication of diabetic peripheral neuropathy or an inflammatory condition. In the most experiments, only one or two evident pain modalities are observed at diabetic peripheral...
Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice

Nam Y, Jung H, Karuppasamy S, Lee JY, Kang KD, Hwang KY, Seong SI, Suh JG

  • Lab Anim Res.
  • 2012 Jun;28(2):123-129.
  • doi: 10.5625/lar.2012.28.2.123
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice...
Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats

Lee JM, Lee MA, Do HN, Song YI, Bae RJ, Lee HY, Park SH, Kang JS, Kang JK

  • Lab Anim Res.
  • 2012 Jun;28(2):115-121.
  • doi: 10.5625/lar.2012.28.2.115
Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats,...
Altered expression of gamma-secretase components in animal model of major depressive disorder induced by reserpine administration

Lee HR, Hwang IS, Kim JE, Choi SI, Lee YJ, Goo JS, Lee EP, Choi HW, Kim HS, Lee JH, Jung YJ, Hwang DY

  • Lab Anim Res.
  • 2012 Jun;28(2):109-114.
  • doi: 10.5625/lar.2012.28.2.109
Altered expression of neurotrophic factors as well as neuroinflammation is commonly associated with Major depressive disorder (MDD) and Alzheimer's disease (AD). To investigate whether or not reserpine-induced MDD affects the...
Autophagy contributes to retardation of cardiac growth in diabetic rats

Lee Y, Hong Y, Lee SR, Chang KT, Hong Y

  • Lab Anim Res.
  • 2012 Jun;28(2):99-107.
  • doi: 10.5625/lar.2012.28.2.99
Diabetes mellitus is a major predictor of heart failure, although the mechanisms by which the disease causes cardiomyopathy are not well understood. The purpose of this study was to determine...
Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract

Kyung J, Kim D, Park D, Yang YH, Choi EK, Lee SP, Kim TS, Lee YB, Kim YB

  • Lab Anim Res.
  • 2012 Jun;28(2):91-97.
  • doi: 10.5625/lar.2012.28.2.91
The anti-inflammatory effects of fuciodan and Cistanche tubulosa (CT) extract were investigated in vitro macrophage culture system and in vivo carrageenan-induced air pouch inflammation model. CT extract inhibited nitric oxide...
Effects of male silkworm pupa powder on the erectile dysfunction by chronic ethanol consumption in rats

Oh HG, Lee HY, Kim JH, Kang YR, Moon DI, Seo MY, Back HI, Kim SY, Oh MR, Park SH, Kim MG, Jeon JY, Shin SJ, Ryu KS, Chae SW, Kim O, Park JK

  • Lab Anim Res.
  • 2012 Jun;28(2):83-90.
  • doi: 10.5625/lar.2012.28.2.83
Erectile dysfunction (ED) is a highly prevalent disorder that affects millions of men worldwide. ED is now considered an early manifestation of atherosclerosis, and consequently, a precursor of systemic vascular...
Ginkgo biloba extract (EGb 761) prevents the ischemic brain injury-induced decrease in parvalbumin expression

Sung JH, Shah FA, Cho EH, Gim SA, Jeon SJ, Kim KM, Kim YM, Kim MO, Koh PO

  • Lab Anim Res.
  • 2012 Jun;28(2):77-82.
  • doi: 10.5625/lar.2012.28.2.77
Ginkgo biloba extract (EGb 761) exerts a neuroprotective effect against ischemic brain injury through an anti-apoptotic mechanism. Parvalbumin is a calcium buffering protein that plays an important role in modulating...
Functions and physiological roles of two types of estrogen receptors, ERalpha and ERbeta, identified by estrogen receptor knockout mouse

Lee HR, Kim TH, Choi KC

  • Lab Anim Res.
  • 2012 Jun;28(2):71-76.
  • doi: 10.5625/lar.2012.28.2.71
Estrogens, a class of steroid hormones, regulate the growth, development, and physiology of the human reproductive system. Estrogens also involve in the neuroendocrine, skeletal, adipogenesis, and cardiovascular systems. Estrogen signaling...

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