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Regulation of Smooth Muscle Excitability

Kang TM

No abstract available.
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Sudden Death Due to Undiagnosed Ludwig’s Angina: An Autopsy Case Report

Jang W, Kang TM, Im SY, Kang M, Ko KS, Choi J

Ludwig’s angina is a rapidly progressive and gangrenous cellulitis in the submandibular, sublingual spaces, and neck. It is characterized by an elevated tongue and laryngeal edema, resulting in airway compromise...
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A Literature Review on the Growth Rate Experiment for Necrophagous Fly Species Commonly Observed in Korea and Consideration for Minimum Postmortem Interval Estimation

Youm KJ, Kang TM, Shin SE, Wang AR, Ko KS, Park SH

Estimation of the minimum post-mortem interval (PMI-min) by means of forensic entomology is mainly based on the results of the growth rate studies on necrophagous flies. However, results of these...
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PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine

Kang TM

[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting...
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Congenital Complete Left-Sided Absence of the Pericardium Incidentally Identified in the Autopsy: A Case Report

Choi J, Kim Y, Kang TM, Wang AR, Ko KS, Park SH

Congenital absence of the pericardium, also known as pericardial agenesis, is an extremely rare anomaly. Although most cases are asymptomatic, some experience chest pain, dyspnea, dizziness, and syncope. A few...
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Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger

Lee JE, Kang TM

  • KMID: 2285341
  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):183-188.
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse...
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Muscarinic receptor subtype controlling the carbachol-induced muscle contraction in guinea pig gastric antrum

Rhee JC, Uhm DY, Kang TM

  • KMID: 1982596
  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):105-111.
Stimulation of muscarinic receptors by carbachol (CCh) in the circular smooth muscle of the guinea pig gastric antrum causes muscle contraction. In the present study, muscarinic receptor subtype controlling the muscle contraction in...
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Death from Malignant Transformation of Untreated Mucinous Borderline Tumor: Case Report

Jang W, Kang TM, Kim Y, Wang AR, Yoon HR, Ko KS, Choi J

Mucinous borderline tumors (MBT) of the ovary with mild to moderately atypical epithelial cells that produce mucin rarely recur and very rarely become malignant after surgery. Due to their low...
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Mechanism of an increase in concentration of intracellular calcium by carbachol in human gastric smooth muscle cell

Moon W, Kim YH, Park DI, Rhee PL, Kim JJ, Koh KC, Rhee JC, Choi KW, Kang TM

  • KMID: 2306142
  • Korean J Med.
  • 2001 May;60(5):432-438.
BACKGROUND: The contraction of smooth muscle depends on an increase in the concentration of intracellular calcium ion and the source of this increase to various stimuli is different according to...
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Characteristics of Muscarinic Receptor Subtypes in Guinea Pig Gallbladder Smooth Muscle

Lee JK, Rhee PL, Kang TM, Kim JJ, Koh KC, Paik SW, Rhee JC

  • KMID: 1891138
  • Korean J Gastroenterol.
  • 1997 Jul;30(1):90-97.
BACKGROUND AND AIMS: Acetylcholine (Ach) is the most irnportant rnediator in vagal-induced and cholecystokinin-induced gallbladder contraction. There are several rnuscarinic receptor subtypes characterized by pharmacologic study. The majority of smooth...
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Two types of voltage-dependent outward potassium currents in smooth muscle cells of rabbit basilar artery

Kang TM, So I, Uhm DY, Kim KW

  • KMID: 1554553
  • Korean J Physiol Pharmacol.
  • 1997 Apr;1(2):169-183.
We have investigated the two types of voltage-dependent outward potassium (K) currents, i.e. delayed rectifier K current (I-K(V)) and 'A-like' transient outward K current (I-to) with patch-clamp technique in single smooth muscle cells...
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Calcium Sources Mediating Human Gallbladder Contraction by Acetylcholine end Cholecystokinin

Yoon YB, Rhee JC, Rhee PL, Lee JK, Kang TM, Uhm DY

  • KMID: 2084833
  • Korean J Gastroenterol.
  • 1998 Jun;31(6):799-813.
BACKGROUND AND AIMS: Gallbladder contraction regulates the bile flow during digestive period and pevents stasis of the lithogenic bile. In addition, abnormal gallbladder motility may cause recurtent biliary pain or...
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Effects of prostaglandin E2 on the spontaneous contractions and electrical activities of the antral circular muscle in guinea-pig stomach

Kim JY, Kim SJ, Kang TM, Lee SJ, Jun JY, So I, Kim KW

  • KMID: 1849844
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):361-368.
The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of Prostaglandin E2...
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Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane

Park SH, Kim A, An J, Cho HS, Kang TM

In contrast to ventricular myocytes, the structural and functional importance of atrial transverse tubules (T-tubules) is not fully understood. Therefore, we investigated the ultrastructure of T-tubules of living rat atrial...
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Neurotensin enhances gastric motility in antral circular muscle strip of guinea-pig.

Koh TY, Kim SJ, Lee SJ, Kang TM, Yeoul JJ, Sim JH, So I, Kim KW

  • KMID: 1580809
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):227-234.
Many reports suggest that neurotensin (NT) in the gastrointestinal tract may play a possible role as a neurotransmitter, a circulating hormone, or a modulator of motor activity. NT exerts various actions in the...
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CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2+ Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells

Nguyen YH, Lee KY, Kim TJ, Kim SJ, Kang TM

Regulation of B cell receptor (BCR)-induced Ca2+ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature...
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Effects of Propofol on the Cytosolic Calcium Concentration of the Astrocytoma Cells

Choi YS, Kang TM, Kim MH, Kwak YK, Choe H, Song HS

BACKGROUND: Propofol is a widely-used intravenous anesthetic with a rapid onset, short duration of action and rapid elimination but the molecular mechanisms of action are not completely understood. Not...
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Mechanisms of Motilin Action on Smooth Muscle of the Human Stomach

Shim SG, Rhee JC, Rhee PL, Choi KW, Jeon SK, Kang TM, Uhm DY, Lee JS, Sung IK, Kim HS

  • KMID: 1606490
  • Korean J Gastroenterol.
  • 2002 Jan;39(1):4-12.
Background/Aims: Motilin is an intestinal peptide that stimulates the contraction of gut smooth muscle. A discrepancy exists between the in vivo (neurally mediated) and in vitro (direct action on a...
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Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⁺ signaling of differentiated C2C12 myotubes

Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM

Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane...
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Evidence for adenosine triphosphate (ATP) as an excitatory neurotransmitter in guinea-pig gastric antrum

Kang TM, Xu W, Kim SJ, Ahn SC, Kim YC, So I, Park MK, Uhm DY, Kim KW

  • KMID: 1554134
  • Korean J Physiol Pharmacol.
  • 1999 Apr;3(2):165-174.
We explore the question of whether adenosine 5'-triphosphate (ATP) acts as an excitatory neurotransmitter in guinea-pig gastric smooth muscle. In an organ bath system, isometric force of the circular smooth muscle of guinea-pig...
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