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Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane

Park SH, Kim A, An J, Cho HS, Kang TM

In contrast to ventricular myocytes, the structural and functional importance of atrial transverse tubules (T-tubules) is not fully understood. Therefore, we investigated the ultrastructure of T-tubules of living rat atrial...
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Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca²⁺ signaling of differentiated C2C12 myotubes

Phuong TT, An J, Park SH, Kim A, Choi HB, Kang TM

Anoctamin 5 (ANO5)/TMEM16E belongs to a member of the ANO/TMEM16 family member of anion channels. However, it is a matter of debate whether ANO5 functions as a genuine plasma membrane...
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Visceral Hypersensitivity and Altered Colonic Motility in Type 2 Diabetic Rat

Sung TS, La JH, Kang TM, Kim TW, Yang IS

  • KMID: 2381307
  • J Neurogastroenterol Motil.
  • 2015 Oct;21(4):581-588.
  • doi: 10.5056/jnm15058
BACKGROUND/AIMS: Abnormal visceral sensitivity and disordered motility are common in patients with diabetes mellitus. The purpose of the present study was to investigate whether visceral sensation and bowel motility were...
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Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse

Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ

Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine...
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CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2+ Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells

Nguyen YH, Lee KY, Kim TJ, Kim SJ, Kang TM

Regulation of B cell receptor (BCR)-induced Ca2+ signaling by CD40 co-stimulation was compared in long-term BCR-stimulated immature (WEHI-231) and mature (Bal-17) B cells. In response to long-term pre-stimulation of immature...
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PKC-Independent Stimulation of Cardiac Na+/Ca2+ Exchanger by Staurosporine

Kang TM

[Ca2+]i transients by reverse mode of cardiac Na+/Ca2+ exchanger (NCX1) were recorded in fura-2 loaded BHK cells with stable expression of NCX1. Repeated stimulation of reverse NCX1 produced a long-lasting...
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Sodium-activated Potassium Current in Guinea pig Gastric Myocytes

Kim YC, Sim JH, Kang TM, Suzuki H, Kim SR, Kwon SC, Xu WX, Lee SJ, Kim KW

This study was designed to identify and characterize Na+ -activated K+ current (I(K(Na))) in guinea pig gastric myocytes under whole-cell patch clamp. After whole-cell configuration was established under 110 mM...
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Ca2+-dependent Long-term Inactivation of Cardiac Na+/Ca2+ Exchanger

Lee JE, Kang TM

  • KMID: 2285341
  • Korean J Physiol Pharmacol.
  • 2007 Oct;11(5):183-188.
Using BHK cells with stable expression of cardiac Na+/Ca2+ exchanger (BHK-NCX1), reverse mode (i.e. Ca2+ influx mode) of NCX1 current was recorded by whole-cell patch clamp. Repeated stimulation of reverse...
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Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes

Kim YC, Sim JH, Lee SJ, Kang TM, Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, So I, Kim KW

  • KMID: 2285316
  • Korean J Physiol Pharmacol.
  • 2005 Apr;9(2):103-108.
To study the direct effect of somatostatin (SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle...
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Five subtypes of muscarinic receptors are expressed in gastric smooth muscles of guinea pig

So I, Yang DK, Kim HJ, Min KW, Kang TM, Kim SJ, Kim KW, Park KH, Jeon JH, Choi KH, Kim IG

  • KMID: 1088657
  • Exp Mol Med.
  • 2003 Feb;35(1):46-52.
Muscarinic receptors play key roles in the control of gastrointestinal smooth muscle activity. However, specific physiological functions of each subtype remain to be determined. In this study, the nonselective cation...
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Mechanisms of Motilin Action on Smooth Muscle of the Human Stomach

Shim SG, Rhee JC, Rhee PL, Choi KW, Jeon SK, Kang TM, Uhm DY, Lee JS, Sung IK, Kim HS

  • KMID: 1606490
  • Korean J Gastroenterol.
  • 2002 Jan;39(1):4-12.
Background/Aims: Motilin is an intestinal peptide that stimulates the contraction of gut smooth muscle. A discrepancy exists between the in vivo (neurally mediated) and in vitro (direct action on a...
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Effects of Propofol on the Cytosolic Calcium Concentration of the Astrocytoma Cells

Choi YS, Kang TM, Kim MH, Kwak YK, Choe H, Song HS

BACKGROUND: Propofol is a widely-used intravenous anesthetic with a rapid onset, short duration of action and rapid elimination but the molecular mechanisms of action are not completely understood. Not...
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Mechanism of an increase in concentration of intracellular calcium by carbachol in human gastric smooth muscle cell

Moon W, Kim YH, Park DI, Rhee PL, Kim JJ, Koh KC, Rhee JC, Choi KW, Kang TM

  • KMID: 2306142
  • Korean J Med.
  • 2001 May;60(5):432-438.
BACKGROUND: The contraction of smooth muscle depends on an increase in the concentration of intracellular calcium ion and the source of this increase to various stimuli is different according to...
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The Stimulatory Effect of IL-1on The Insulin Secretion and Its Relating Factors

Jeong IK, Oh SH, Kang TM, Jeong JH, Min YK, Lee MS, Lee MK, Kim KW

  • KMID: 1905889
  • J Korean Diabetes Assoc.
  • 2000 Aug;24(4):431-443.
BACKGROUND: The inhibitory effect of IL-1 on the insulin secretion has been validated in pathogenesis of type 1 diabetes, but complex results about the stimulatory effect of IL-1 ...
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Neurotensin enhances gastric motility in antral circular muscle strip of guinea-pig.

Koh TY, Kim SJ, Lee SJ, Kang TM, Yeoul JJ, Sim JH, So I, Kim KW

  • KMID: 1580809
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):227-234.
Many reports suggest that neurotensin (NT) in the gastrointestinal tract may play a possible role as a neurotransmitter, a circulating hormone, or a modulator of motor activity. NT exerts various actions in the...
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Muscarinic receptor subtype controlling the carbachol-induced muscle contraction in guinea pig gastric antrum

Rhee JC, Uhm DY, Kang TM

  • KMID: 1982596
  • Korean J Physiol Pharmacol.
  • 2000 Apr;4(2):105-111.
Stimulation of muscarinic receptors by carbachol (CCh) in the circular smooth muscle of the guinea pig gastric antrum causes muscle contraction. In the present study, muscarinic receptor subtype controlling the muscle contraction in...
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Evidence for adenosine triphosphate (ATP) as an excitatory neurotransmitter in guinea-pig gastric antrum

Kang TM, Xu W, Kim SJ, Ahn SC, Kim YC, So I, Park MK, Uhm DY, Kim KW

  • KMID: 1554134
  • Korean J Physiol Pharmacol.
  • 1999 Apr;3(2):165-174.
We explore the question of whether adenosine 5'-triphosphate (ATP) acts as an excitatory neurotransmitter in guinea-pig gastric smooth muscle. In an organ bath system, isometric force of the circular smooth muscle of guinea-pig...
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Calcium Sources Mediating Human Gallbladder Contraction by Acetylcholine end Cholecystokinin

Yoon YB, Rhee JC, Rhee PL, Lee JK, Kang TM, Uhm DY

  • KMID: 2084833
  • Korean J Gastroenterol.
  • 1998 Jun;31(6):799-813.
BACKGROUND AND AIMS: Gallbladder contraction regulates the bile flow during digestive period and pevents stasis of the lithogenic bile. In addition, abnormal gallbladder motility may cause recurtent biliary pain or...
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Effects of prostaglandin E2 on the spontaneous contractions and electrical activities of the antral circular muscle in guinea-pig stomach

Kim JY, Kim SJ, Kang TM, Lee SJ, Jun JY, So I, Kim KW

  • KMID: 1849844
  • Korean J Physiol Pharmacol.
  • 1998 Jun;2(3):361-368.
The spontaneous contractions of gastric smooth muscles are regulated by slow waves, which are modulated by both nervous system and humoral agents. This study was designed to examine the effects of Prostaglandin E2...
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Regulation of Smooth Muscle Excitability

Kang TM

No abstract available.
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