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Mu-Opioid Receptor Polymorphisms and Breast Cancer in a Korean Female Adult Population: A Retrospective Study

Oh CS, Lee SH, Yoo YB, Yang JH, Kim SH

Distribution of A118G single nucleotide polymorphism (SNP) in the mu-opioid receptor 1 gene (OPRM1) differs with ethnicity. We assessed the distribution of this SNP in Korean women with breast cancer...
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An Innovative Ultrasound Technique for Evaluation of Tumor Vascularity in Breast Cancers: Superb Micro-Vascular Imaging

Park AY, Seo BK, Cha SH, Yeom SK, Lee SW, Chung HH

Tumor vascularity is an important indicator for differential diagnosis, tumor growth, and prognosis. Superb micro-vascular imaging (SMI) is an innovative ultrasound technique for vascular examination that uses a multidimensional filter...
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Experience with Bilateral Risk-Reducing Mastectomy for an Unaffected BRCA Mutation Carrier

Maeshima Y, Oseto K, Katsuragi , Yoshimoto , Takahara S, Yamauchi A

Women with BRCA1/2 mutations have a high risk of breast cancer and may opt for risk-reducing mastectomy (RRM). We report a 38-year-old Japanese woman who was diagnosed as a BRCA2...
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Prognostically Distinctive Subgroup in Pathologic N3 Breast Cancer

Kim YY, Park HK, Lee KH, Kim KI, Chun YS

PURPOSE: The aim of this retrospective study was to investigate whether there are prognostically different subgroups among patients with pathologic N3 (pN3) breast cancer. METHODS: The records of 220 patients who...
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Eribulin Mesylate Combined with Local Treatment for Brain Metastasis from Breast Cancer: Two Case Reports

Byun KD, Ahn SG, Baik HJ, Lee A, Bae KB, An MS, Kim KH, Shin JH, Park HK, Cho H, Jeong J, Kim TH

The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase...
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Breast Magnetic Resonance Imaging for Assessment of Internal Mammary Lymph Node Status in Breast Cancer

Lee HW, Kim SH

PURPOSE: The purpose of this study was to assess magnetic resonance imaging (MRI) features of malignant internal mammary lymph nodes (IMLNs) and benign IMLNs in breast cancer patients. METHODS: From 2009...
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Breast Cancer Mortality among Asian-American Women in California: Variation according to Ethnicity and Tumor Subtype

Parise C, Caggiano V

PURPOSE: Asian-American women have equal or better breast cancer survival rates than non-Hispanic white women, but many studies use the aggregate term "Asian/Pacific Islander" (API) or consider breast cancer as...
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Molecular Portrait of the Normal Human Breast Tissue and Its Influence on Breast Carcinogenesis

Margan MM, Jitariu AA, Cimpean AM, Nica C, Raica M

Normal human breast tissue consists of epithelial and nonepithelial cells with different molecular profiles and differentiation grades. This molecular heterogeneity is known to yield abnormal clones that may contribute to...
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Role of STAT3 Phosphorylation in Ethanol-Mediated Proliferation of Breast Cancer Cells

Narayanan , Nandabalan SK, Baddireddi LS

PURPOSE: In this study, we investigated the molecular mechanism involved in ethanol (EtOH)-mediated proliferation of breast cancer cells. METHODS: EtOH concentration was optimized by studying its effect on cell proliferation in...
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Hornerin Is Involved in Breast Cancer Progression

Choi J, Kim DI, Kim J, Kim BH, Kim A

PURPOSE: The S100 gene family, which comprises over 20 members, including S100A1, S100A2, S100A8, S100A9, profilaggrin, and hornerin encodes low molecular weight calcium-binding proteins with physiological and pathological roles in...
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High Expression of Urokinase-Type Plasminogen Activator Is Associated with Lymph Node Metastasis of Invasive Ductal Carcinoma of the Breast

Kim EY, Do SI, Hyun K, Park YL, Kim DH, Chae SW, Sohn JH, Park CH

PURPOSE: In the present study, we evaluated the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1) by performing immunohistochemical staining to determine whether they were reliable...
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Predictive Value of Molecular Subtyping for Locoregional Recurrence in Early-Stage Breast Cancer with N1 without Postmastectomy Radiotherapy

Wen G, Zhang JS, Zhang YJ, Zhu YJ, Huang XB, Guan XX

PURPOSE: This study was designed to investigate the relationship between molecular subtype and locoregional recurrence (LRR) in patients with early-stage breast cancer with 1-3 positive axillary lymph nodes (ALNs) and...
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Aberrant Expression of Breast Development-Related MicroRNAs, miR-22, miR-132, and miR-212, in Breast Tumor Tissues

Damavandi , Torkashvand S, Vasei M, Soltani BM, Tavallaei , Mowla SJ

PURPOSE: MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that posttranscriptionally regulate the expression of most genes in the human genome. miRNAs are often located in chromosomal...
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Lymph Node Ratio as a Risk Factor for Locoregional Recurrence in Breast Cancer Patients with 10 or More Axillary Nodes

Kim SW, Choi DH, Huh SJ, Park W, Nam SJ, Kim SW, Lee JE, Im YH, Ahn JS, Park YH

PURPOSE: We analyzed the association of lymph node ratio (LNR) wth locoregional control (LRC) in breast cancer patients with ≥10 involved axillary lymph nodes who underwent multimodality treatment. METHODS: We retrospectively...
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Aberrant Promoter Methylation at CpG Cytosines Induce the Upregulation of the E2F5 Gene in Breast Cancer

Ali A, Ullah F, Ali IS, Faraz A, Khan M, Shah ST, Ali N, Saeed M

PURPOSE: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during...
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Features of Pure Lobular Carcinoma In Situ on Magnetic Resonance Imaging Associated with Immediate Re-Excision after Lumpectomy

Chu AJ, Cho N, Park IA, Cho SW

PURPOSE: To evaluate imaging features of pure lobular carcinoma in situ (LCIS) on magnetic resonance imaging (MRI) in patients who underwent immediate re-excision after lumpectomy. METHODS: Twenty-six patients (46.1±6.7 years) with...
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Predictors of Recurrent Ductal Carcinoma In Situ after Breast-Conserving Surgery

Kim JY, Park K, Kang G, Kim HJ, Gwak G, Shin YJ

PURPOSE: Local recurrence is a major concern in patients who have undergone surgery for ductal carcinoma in situ (DCIS). The present study assessed whether the expression levels of hormone receptors,...
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