- A Review on Renal Toxicity Profile of Common Abusive Drugs
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Singh VP, Singh N, Jaggi AS
- KMID: 2285470
- Korean J Physiol Pharmacol.
- 2013 Aug;17(4):347-357.
- doi: 10.4196/kjpp.2013.17.4.347
Drug abuse has become a major social problem of the modern world and majority of these abusive drugs or their metabolites are excreted through the kidneys and, thus, the renal... -
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- Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms
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Aulakh AS, Randhawa P, Singh N, Jaggi AS
- KMID: 2371032
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):145-152.
- doi: 10.4196/kjpp.2017.21.2.145
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote... -
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- Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
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Kant R, Bali A, Singh N, Jaggi AS
- KMID: 1429381
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):111-120.
- doi: 10.4196/kjpp.2013.17.2.111
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well... -
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- A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents
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Randhawa P, Singh K, Singh N, Jaggi AS
- KMID: 2285521
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):279-288.
- doi: 10.4196/kjpp.2014.18.4.279
Ulcerative colitis and Crohn's disease are a set of chronic, idiopathic, immunological and relapsing inflammatory disorders of the gastrointestinal tract referred to as inflammatory bowel disorder (IBD). Although the etiological... -
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- Effect of Neurosteroid Modulation on Global Ischaemia-Reperfusion-Induced Cerebral Injury in Mice
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Grewal AK, Jaggi AS, Rana AC, Singh N
- KMID: 2285474
- Korean J Physiol Pharmacol.
- 2013 Dec;17(6):485-491.
- doi: 10.4196/kjpp.2013.17.6.485
The present study was designed to investigate the putative effect of neurosteroid modulation on global ischaemia-reperfusion-induced cerebral injury in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant... -
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- Effects of Erythropoietin on Memory Deficits and Brain Oxidative Stress in the Mouse Models of Dementia
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Kumar R, Jaggi AS, Singh N
- KMID: 2071704
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):345-352.
- doi: 10.4196/kjpp.2010.14.5.345
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice. Memory impairment was produced by scopolamine (0.5 mg/kg, i.p.) and intracerebroventricular streptozotocin (i.c.v STZ,... -
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- Animals models of spinal cord contusion injury
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Verma R, Virdi JK, Singh N, Jaggi AS
- KMID: 2430759
- Korean J Pain.
- 2019 Jan;32(1):12-21.
- doi: 10.3344/kjp.2019.32.1.12
Spinal cord contusion injury is one of the most serious nervous system disorders, characterized by high morbidity and disability. To mimic spinal cord contusion in humans, various animal models of... -
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- Ameliorative Effect of a Selective Endothelin ETA Receptor Antagonist in Rat Model of L-Methionine-induced Vascular Dementia
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Mangat GS, Jaggi AS, Singh N
- KMID: 2285511
- Korean J Physiol Pharmacol.
- 2014 Jun;18(3):201-209.
- doi: 10.4196/kjpp.2014.18.3.201
The present study was designed to investigate the efficacy of selective ET(A) receptor antagonist, ambrisentan on hyperhomocysteinemia-induced experimental vascular dementia. L-methionine was administered for 8 weeks to induce hyperhomocysteinemia and... -
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- Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
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Singh L, Kulshrestha R, Singh N, Jaggi AS
- KMID: 2410087
- Korean J Physiol Pharmacol.
- 2018 May;22(3):225-234.
- doi: 10.4196/kjpp.2018.22.3.225
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic... -
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- Advanced Glycation End Products and Diabetic Complications
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Singh VP, Bali A, Singh N, Jaggi AS
- KMID: 2285485
- Korean J Physiol Pharmacol.
- 2014 Feb;18(1):1-14.
- doi: 10.4196/kjpp.2014.18.1.1
During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent adducts with the plasma proteins through a non-enzymatic process known as glycation. Protein glycation and formation of advanced glycation... -
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- An integrated review on new targets in the treatment of neuropathic pain
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Khangura R, Sharma J, Bali A, Singh N, Jaggi AS
- KMID: 2443611
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):1-20.
- doi: 10.4196/kjpp.2019.23.1.1
Neuropathic pain is a complex chronic pain state caused by the dysfunction of somatosensory nervous system, and it affects the millions of people worldwide. At present, there are very few... -
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- Conditioning-induced cardioprotection: Aging as a confounding factor
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Randhawa P, Bali A, Virdi JK, Jaggi AS
- KMID: 2418997
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):467-479.
- doi: 10.4196/kjpp.2018.22.5.467
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase... -
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