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A Nationwide Survey on the Hospital Vaccination Policies in Korea

Park SH, Lee MS, Kim SR, Kwak YG

BACKGROUND: Healthcare personnel (HCP) are at risk of being exposed to or transmitting infections in hospitals, and vaccination against vaccine-preventable diseases (VPDs) is a well-known preventive strategy. Vaccination against influenza,...
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Delayed-Onset Anaphylaxis Caused by IgE Response to Influenza Vaccination

Kim MJ, Shim DH, Cha HR, Kim CB, Kim SY, Park JH, Sohn MH, Lee JM, Kim KW

Influenza vaccine-associated anaphylaxis is a very rare allergic reaction to vaccines, but the most concerning and life-threatening adverse reaction. Although the safety of influenza vaccines has been well documented, occasional...
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Influenza Vaccine Effectiveness among Elementary School Students in Korea during the 2016-2017 Seasons: a Cross-Sectional Survey

Kim YM, Kang S, Lim JS, Kim DH

BACKGROUND: Annual vaccination is the principal way to reduce the mortality and morbidity associated with influenza. In the 2016–2017 influenza seasons, the influenza epidemic appeared to exhibit a different pattern...
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Comparison of antigenic mutation during egg and cell passage cultivation of H3N2 influenza virus

Park YW, Kim YH, Jung HU, Jeong OS, Hong EJ, Kim H, Lee JI

PURPOSE: When influenza viruses are cultured in eggs, amino acid mutations of the hemagglutinin may occur through egg adaptation. On the other hand, when influenza viruses are cultured in animal...
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Selecting the Priority Research Topics Addressing Unmet Post-immunization Safety Needs: A Model for Generating Research Proposal and Designing a Questionnaire for the Clinical Experts

Kim HJ, Lee H, Kim JH, Yoon D, Noh Y, Shin JY

OBJECTIVE: To gather inputs from clinical experts on selecting and prioritizing research topics, to address unmet vaccine safety needs. METHODS: A questionnaire containing 15 vaccine safety assessment research proposals was sent...
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Evaluation of Protective Immunity of Peptide Vaccines Composed of a 15-mer N-terminal Matrix Protein 2 and a Helper T-Cell Epitope Derived from Influenza A Virus

Kim JK, Cheong S, Lee MK

The matrix protein 2 of influenza A virus (IFAV) has a relatively conserved ectodomain (M2e) composed of 23 amino acids, and M2e-based vaccines have been suggested to induce broad protective...
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Acute fulminant myocarditis following influenza vaccination requiring extracorporeal membrane oxygenation

Kim YJ, Bae JI, Ryoo SM, Kim WY

The inactivated influenza vaccination is generally safe with mostly mild side effects. We report a rare but fatal adverse event following influenza vaccination. A previously healthy 27-year-old woman who received...
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Non-Mandatory Influenza Vaccination Rates among Healthcare Workers during the 2017–2018 Influenza Season: a Multicenter Study in Korea

Kang JM, Lee J, Park YS, Park Y, Kwak YG, Song JE, Choi YJ

PURPOSE: Annual influenza vaccination is the best strategy to prevent healthcare-associated influenza transmission. Influenza vaccination rates among healthcare workers (HCWs) vary by country, region, and year. We investigated the influenza...
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Comparison of Split versus Subunit Seasonal Influenza Vaccine in Korean Children over 3 to under 18 Years of Age

Kang S, Kim DH, Eun BW, Kim NH, Kang EK, Lee BS, Kim YK

PURPOSE: This study was conducted to compare immunogenicities and reactogenicities of the trivalent inactivated subunit influenza vaccine and split influenza vaccine in Korean children and adolescents. METHODS: In total, 202 healthy...
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Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6–35 Months

Lee JH, Cho HK, Kim KH, Lee J, Kim YJ, Eun BW, Kim NH, Kim DH, Jo DS, Kim HM, Kim YK

BACKGROUND: The titer of influenza vaccine-induced antibodies declines over time, and younger children have lower immunogenicity and shorter duration of immunity. This study aimed to compare persistence of antibody at...
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Development of a HA1-specific enzyme-linked immunosorbent assay against pandemic influenza virus A H1N1

Shim DH, Kim MJ, Cha HR, Park ES, Kim AR, Park JH, Park HC, Song D, Lee JM

PURPOSE: Enzyme-linked immunosorbent assay (ELISA) has been used in the diverse field to evaluate influenza virus infection; for the surveillance, diagnosis, efficacy evaluation, and development of the vaccine. The aim...
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Nucleoprotein vaccine induces cross-protective cytotoxic T lymphocytes against both lineages of influenza B virus

Lee SY, Kang JO, Chang J

PURPOSE: The influenza B virus diverges into two antigenically distinct lineages: B/Yamagata and B/Victoria. Influenza B is the dominant circulating virus during some influenza seasons, and recent data demonstrated that...
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Immunogenicity and Safety of Inactivated Influenza Vaccine in Healthy Korean Children and Adolescent

Ri S, Kim MJ, Kim YK

PURPOSE: This study aimed to evaluate the immunogenicity and safety of a trivalent inactivated influenza vaccine (TIV) among healthy Korean children and adolescents. METHODS: From October to December 2008, 65 healthy...
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The Influence of Mothers' Native Country on Multicultural Adolescents' Seasonal Influenza Vaccinations in Multicultural Adolescents Using Data from the 13th (2017) Korea Youth Risk Behavior Web-Based Survey

Kwon MY, Jeong S

PURPOSE: The aim of this study was to evaluate the influence of the mothers' native country on influenza vaccinations in adolescents in multicultural families. METHODS: Data were gathered from the 13th...
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Safety and Immunogenicity of an Egg-Cultivated Quadrivalent Inactivated Split-virion Influenza Vaccine (GC3110A) in Healthy Korean Children: a Randomized, Double-blinded, Active-controlled Phase III Study

Lee J, Lee KY, Kim JH, Kim CS, Eun BW, Kim HM, Kim DH, Hong YJ, Choi YY, Jo DS, Ma SH, Kang JH

BACKGROUND: The frequency with which the 2 B lineages have been found to cocirculate in a season has been on the rise, which has spurred the need for a quadrivalent...
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Phase 4, Post-Marketing Safety Surveillance of the MF59-Adjuvanted Influenza Vaccines FLUAD® and VANTAFLU® in South Korean Subjects Aged ≥65 Years

Yoo BW, Kim CO, Izu A, Arora AK, Heijnen E

BACKGROUD: Influenza vaccination is recommended for adults aged ≥65 years as they are at high risk of significant morbidity and mortality. This open-label, multicenter, post-marketing surveillance study assessed the safety...
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Optimized clade 2.3.2.1c H5N1 recombinant-vaccine strains against highly pathogenic avian influenza

Jang JW, Lee CY, Kim IH, Choi JG, Lee YJ, Yuk SS, Lee JH, Song CS, Kim JH, Kwon HJ

A/Puerto Rico/8/34 (PR8)-derived recombinant viruses have been used for seasonal flu vaccines; however, they are insufficient for vaccines against some human-fatal H5N1 highly pathogenic avian influenza (HPAI) viruses (HPAIV) due...
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The impact of an educational intervention on parents' decisions to vaccinate their <60-month-old children against influenza

Choi A, Kim DH, Kim YK, Eun BW, Jo DS

PURPOSE: Seasonal influenza can be prevented by vaccination. Disease prevention in children aged
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Surveillance and compensation claims for adverse events following immunization from 2011 to 2016 in the Republic of Korea

Kim MK, Lee YK, Kim TE, Kong I, Yang HJ, Suh ES

PURPOSE: In recent years, research on reported adverse events following immunization (AEFI) and claims filed for compensation has been lacking. We reviewed reported AEFIs and compensation claims in Korea from...
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The significance of avian influenza virus mouse-adaptation and its application in characterizing the efficacy of new vaccines and therapeutic agents

Choi WS, Lloren KK, Baek YH, Song MS

Due to the increased frequency of interspecies transmission of avian influenza viruses, studies designed to identify the molecular determinants that could lead to an expansion of the host range have...
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