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A Huge Anterior Mediastinal Thymoma of an Infant: A Case Report

Hwang IK, Hahn SM, Kim HS, Han JW, Lyu CJ

A seven months old male infant visited Severance Children's Hospital for evaluation of anterior mediastinal mass. With chest computed tomography (CT) image and biopsy, precursor T-cell lymphoblastic lymphoma was suspected...
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Joint Health Status in Hemophilia Patients Using Hemophilia Joint Health Score and Pettersson Score

Roh YY, Choi YH, Park M, Hahn JH, Kim SH, Shin YJ, Hahn SM, Lee HY, Park JM, Hong JP, Lyu CJ, Han JW

BACKGROUND: Comprehensive clinical and radiologic follow-up is needed to preserve joint functions and quality of life in hemophilia using clinimetric tools such as Hemophilia joint health score (HJHS) or Pettersson...
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A Case of Hodgkin Lymphoma Developed in an Ataxia-telangiectasia Patient

Lim JY, Jeon M, Kim HS, Han JW, Lyu CJ, Hahn SM

Ataxia-telangiectasia (AT) is characterized by cerebellar ataxia, progressive immunodeficiency, radiation sensitivity, telangiectasia, and predisposition to malignancy. AT patients have a 100-fold increased risk for the development of lymphoid malignancies. It...
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Surgical Procedures Requiring Hospitalization and Perioperative Management for Patients with Hereditary Bleeding Disorders

Seo HS, Ahn WK, Hahn SM, Han JW, Lyu CJ

Background: Hemophilia requires a lifetime care for bleeding control and complications. Although patients diagnosed with hemophilia receive factor replacement, they also experience a variety of medical problems as they age....
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A Case of Erdheim-Chester Disease Developed during Treatment of Leukemia in a Child

Hong JP, Ahn WK, Lim JY, Jung JE, Hahn SM, Han JW, Lyu CJ

Erdheim-Chester disease (ECD) is a rare non-Langerhan's cell histiocytosis disorder characterized by replacement of normal tissue by lipid-laden histiocytes affecting various organs. A few pediatric cases have been reported worldwide....
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Lower Diagnostic Value of Bone Marrow Biopsy in Children with Fever of an Unknown Origin

Yang SM, Jin SL, Kim HS, Hahn SM, Lyu CJ, Han JW

BACKGROUND: Diagnostic value of Bone marrow (BM) biopsies for fever of unknown origin (FUO) remain controversial and BM biopsies are difficult to perform in young patients. Our study aimed to...
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Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea

Lee KM, Ahn WK, Han JW, Lyu CJ, Hahn SM

Background: Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review...
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Hereditary Antithrombin Deficiency with Hemorrhagic Cerebral Infarction and Cardiac Thrombosis Occurred in Neonatal Period: A Case Report

Park JS, Choi YJ, Hahn SM, Kim HS, Han JW, Oh SH, Lyu CJ

Antithrombin (AT) is the main inhibitor of blood coagulation proteases. Hereditary AT deficiency is an autosomal-dominant thrombophilic disorder caused by a SERPINC1 abnormality, it represents a risk factor for thromboembolic...
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Descriptive Analysis of Histiocytic and Dendritic Cell Neoplasms: A Single-Institution Experience

Kim HM, Yang WI, Lyu CJ, Hahn SM, Yoon SO

Purpose: Histiocytic and dendritic cell neoplasms are rare hematologic tumors. This study aimed to describe the epidemiologic features of the entire spectrum of histiocytic and dendritic cell neoplasms, including clinicopathological variables...
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Adverse Factors and the Role of Cisplatin and Vinca Alkaloids for Hearing Impairment in Childhood Cancer Patients and Survivors

Hur MW, Hahn SM, Moon IS, Lim JY, Lee SM, Lyu CJ, Han JW

BACKGROUND: Although combined chemotherapy has increased survival rates among children with cancer, such treatments can induce sensorineural hearing loss. Therefore, we aimed to identify risk factors for hearing impairments in...
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Successful Selective CD34+ Cell Infusion after Late Graft Failure of Hematopoietic Stem Cell Transplantation in Two Cases of Severe Aplastic Anemia

Hahn SM, Sol IS, Jin SL, Kim HS, Han JW, Kim SH, Lyu CJ

  • KMID: 1807603
  • Clin Pediatr Hematol Oncol.
  • 2013 Oct;20(2):108-111.
Matched sibling bone marrow transplantation (BMT) in severe aplastic anemia (SAA) has been known as the treatment of choice in children and young adults. To overcome graft failure, second stem...
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Aberrant DNA Methylation of CDH1, p16 and DAPK in Childhood Acute Lymphoblastic Leukemia

Hahn SM, Kwon SY, Kim HS, Han JW, Lyu CJ

BACKGROUND: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia with potential involvement in the inactivation of regulatory cell cycle and apoptosis genes. METHODS: To evaluate the...
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Posttransplant lymphoproliferative disorders after solid organ and hematopoietic stem cell transplantation: a nationwide cohort study in Korea

Ihn K, Hahn SM, Lee M, Kim EH, Kang JM, Lim SM, Joo DJ, Jung I

Background: osttransplant lymphoproliferative disorders (PTLD) are the majority of cancer diagnoses after solid organ trans-plantation (SOT) and allogeneic hematopoietic stem cell transplantation (HSCT) with a high incidence of PTLD developed...
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A Case of Successfully Treated Severe Heart Failure due to Cyclophosphamide Induced Cardiomyopathy

Park JM, Hahn SM, Han JW, Lyu CJ

Cyclophosphamide-induced cardiotoxicity is an uncommon complication especially in patients who have never undergone mediastinal irradiation or cardiotoxic chemotherapy and do not have underlying cardiac diseases. Here, we describe the case...
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Primary Extragonadal Germ Cell Tumors in Klinefelter Syndrome: 10-Years of Experience from a Single Institute

Kim Y, Ahn WK, Han JW, Hahn SM, Kwon SY, Lyu CJ

Background: Approximately 8% of male patients presenting with primary mediastinal germ cell tumors (GCTs) have Klinefelter syndrome (KS), while patients diagnosed with retroperitoneal GCTs also exhibit a range of chromosomal...
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Delta Neutrophil Index as an Early Marker for Distinguishing Myeloid from Childhood Acute Leukemia

Hong JP, Kim S, Kim BR, Yoon SH, Hahn SM, Kim MK

BACKGROUND: The accurate and early diagnosis of acute myeloid leukemia (AML) is important to choose proper treatment option depending on the risk stratification. The delta neutrophil index (DNI) is a...
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Factors Associated with Emotional Distress in Children and Adolescents during Early Treatment for Cancer

Sohn IJ, Han JW, Hahn SM, Song DH, Lyu CJ, Cheon KA

PURPOSE: Children and adolescents diagnosed with cancer experience emotional distress, such as sadness, worrying, and irritability. However, there is little information about the psychological well-being of parents at the time...
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The Efficacy of Alternate Systemic Intravenous Chemotherapy and Intra-arterial Chemotherapy Approach for Eye Globe Salvage in Retinoblastoma

Han JW, Lee CS, Hahn SM, Ahn WK, Kim HS, Yun H, Lee SC, Kim BM, Kim DJ, Lyu CJ

Purpose The advances in the treatment of retinoblastoma have enabled salvaging the globe in advanced stages with intra-arterial chemotherapy (IAC). We developed a strategy of alternate application of systemic intravenous...
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Bronchiolitis Obliterans Syndrome after Allogenic Hematopoietic Stem Cell Transplantation in Pediatric Patients

Lim JY, Hahn SM, Kim HS, Han JW, Lyu CJ

BACKGROUND: Bronchiolitis obliterans syndrome (BOS) is a life-threatening lung complication after allogenic hematopoietic stem cell transplantation (HSCT). As long-term survival following allogenic HSCT has improved, the number of BOS patients...
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Prevalence and Clinical Implication of Partial Tandem Duplication of the Mixed Lineage Leukemia Gene in Pediatric Acute Leukemia

Jin SL, Hahn SM, Kim HS, Lyu CJ, Han JW

BACKGROUND: The mixed lineage leukemia (MLL) gene may induce hematopoiesis and leukemia. Partial tandem duplication of MLL (MLL-PTD) is associated with poor prognosis in acute myeloid leukemia (AML); however, the...
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