Clin Pediatr Hematol Oncol.  2016 Oct;23(2):184-187. 10.15264/cpho.2016.23.2.184.

A Case of Hodgkin Lymphoma Developed in an Ataxia-telangiectasia Patient

Affiliations
  • 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. bluenile88@yuhs.ac

Abstract

Ataxia-telangiectasia (AT) is characterized by cerebellar ataxia, progressive immunodeficiency, radiation sensitivity, telangiectasia, and predisposition to malignancy. AT patients have a 100-fold increased risk for the development of lymphoid malignancies. It is important to consider AT in a child with pre-existing ataxia, or lymphoid malignancy that was diagnosed at a younger age than expected. This consideration avoids the confusion between ataxia development and toxicity from chemotherapy. Hodgkin's lymphoma (HL) is usually treated with chemotherapy and/or radiotherapy. Unfortunately, when treated with conventional doses of radiotherapy, AT patients invariably experience devastating necrosis of their normal tissues. Therefore, a new treatment protocol for patients with HL in AT must be established. In this paper, we report the case of an 8-year-old female patient with HL in AT who was treated with chemotherapy. This patient was also treated with brentuximab (which targets CD30) for salvage therapy after the disease progressed.

Keyword

Ataxia-telangiectasia; Hodgkin lymphoma; Chemotherapy; Brentuximab

MeSH Terms

Ataxia
Ataxia Telangiectasia*
Cerebellar Ataxia
Child
Clinical Protocols
Drug Therapy
Female
Hodgkin Disease*
Humans
Necrosis
Radiation Tolerance
Radiotherapy
Salvage Therapy
Telangiectasis
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