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Theragnostic ultrasound using microbubbles in the treatment of prostate cancer

Lee HJ, Yoon YI, Bae YJ

The use of gas-filled microbubbles in perfusion monitoring as intravascular ultrasound contrast agents has recently become more common. Additionally, microbubbles are employed as carriers of pharmaceutical substances or genes. Microbubbles...
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Therapeutic efficacy of nanomedicines for prostate cancer: An update

Lakshmanan VK

Recent advances in cancer nanomedicine have attracted remarkable attention in medical sectors. Pharmacologic research on nanomedicines, including targeted cancer therapy, has increased dramatically in the past 5 years. The success...
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Mitochondrial Gene Therapy

Ko KS

Mitochondrial dysfunction contributes to a large variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Increasing pharmacological efforts toward therapeutic interventions...
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Effect of Drug Carrier Melting Points on Drug Release of Dexamethasone-Loaded Microspheres

Park JH, Kwon DY, Heo JY, Park SH, Park JY, Lee B, Kim JH, Kim MS

Here, we examined the effect of melting point of drug carriers on drug release of dexamethasone (Dex)-loaded microspheres. We prepared poly(L-lactide-ran-ε-caprolactone) (PLC) copolymers with varying compositions of poly(εcaprolactone) (PCL) and...
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Development of Biodegradable Polymer Releasing Anticancer Drug for Intratumoral Chemotherapy of Brain Tumor-in Vitro Results

Cho YC, Cho HJ, An JH, Lee WC, Yoon SH

  • KMID: 2188954
  • J Korean Neurosurg Soc.
  • 2004 Apr;35(4):422-426.
OBJECTIVE: The authors present two polymers as carriers of anti-neoplastic agents for intratumoral chemotherapy. We investigated in vitro tumor cytotoxicity againt C6 glioma cells with 20ul cis-platinum (CDDP)-polymer. METHODS: We...
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Temporal and subcellular distributions of Cy5.5-labeled hyaluronic acid nanoparticles in mouse organs during 28 days as a drug carrier

Lin C, Kim SB, Yon JM, Park SG, Gwon LW, Lee JG, Baek IJ, Lee BJ, Yun YW, Nam SY

Temporal and subcellular distributions of hyaluronic acid (HA) as a degradable nanoparticle (NP) in animals were investigated to determine if HA-NP could be utilized as an appropriate drug delivery system....
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MRI Findings and Prediction of Time to Progression of Patients with Hepatocellular Carcinoma Treated with Drug-eluting Bead Transcatheter Arterial Chemoembolization

Lee S, Kim KA, Park MS, Choi SY

The purpose of this study was to investigate the utility of MRI findings after drug-eluting beads (DEB) - transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma in predicting time to progression...
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Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma

Liu YS, Ou MC, Tsai YS, Lin XZ, Wang CK, Tsai HM, Chuang MT

OBJECTIVE: To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). MATERIALS AND METHODS: A total of...
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Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors

Daum S, Magnusson , Pes L, Garcia Fernandez J, Chercheja , Medda F, Nollmann F, Koester SD, Perez Galan P, Warnecke A, Abu Ajaj K, Kratz F

PURPOSE: The purpose of this study was to investigate the albumin-binding compound 111In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. METHODS: 111In-C4-DTPA was injected in...
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Review of the developmental trend of implant surface modification using organic biomaterials

Hwang ST, Han IH, Huh JB, Kang JK, Ryu JJ

  • KMID: 2321787
  • J Korean Acad Prosthodont.
  • 2011 Jul;49(3):254-262.
PURPOSE: This study aims to evaluate and prospect for current research trend and developmental perspectives via analyzing recent biomaterial coated-implants study. MATERIALS AND METHODS: To investigate each subject respectively, several biomaterials...
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Generation and Immunity Testing of a Recombinant Adenovirus Expressing NcSRS2-NcGRA7 Fusion Protein of Bovine Neospora caninum

Jia LJ, Zhang SF, Qian NC, Xuan XN, Yu LZ, Zhang XM, Liu MM

Neospora caninum is the etiologic agent of bovine neosporosis, which affects the reproductive performance of cattle worldwide. The transmembrane protein, NcSRS2, and dense-granule protein, NcGRA7, were identified as protective antigens...
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The Alginate Layer for Improving Doxorubicin Release and Radiolabeling Stability of Chitosan Hydrogels

Kwon JI, Lee CM, Jeong HS, Oh PS, Hwang H, Lim ST, Sohn MH, Jeong HJ

PURPOSE: Chitosan hydrogels (CSH) formed through ionic interaction with an anionic molecule are suitable as a drug carrier and a tissue engineering scaffold. However, the initial burst release of drugs...
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A Novel Recombinant BCG Vaccine Encoding Eimeria tenella Rhomboid and Chicken IL-2 Induces Protective Immunity Against Coccidiosis

Wang Q, Chen L, Li J, Zheng J, Cai N, Gong P, Li S, Li H, Zhang X

  • KMID: 1792178
  • Korean J Parasitol.
  • 2014 Jun;52(3):251-256.
A novel recombinant Bacille Calmette-Guerin (rBCG) vaccine co-expressed Eimeria tenella rhomboid and cytokine chicken IL-2 (chIL-2) was constructed, and its efficacy against E. tenella challenge was observed. The rhomboid gene...
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Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review

Lee EW, Alanis L, Cho SK, Saab S

Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage,...
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Anticancer effect of liposome incorporated with methotrexate and antibody against tumor specific surface antigen of rat hepatoma

Shin YS, Paik EM, Ahn YH, Kim BS, Kim YS

antibody against tumor specific surface membrane protein was produced by immunizing a New Zealand White rabbit with antigen (66 kDa) prepared from the plasma membrane of rat hepatoma induced...
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Preparation of Collagen Modified Hyaluronan Microparticles as Antibiotics Carrier

Lee JE, Park JC, Kim JG, Suh H

Hyaluronan (HA), a natural glycoaminoglycan featuring an extracellular matrix, has been suggested as an effective biocompatible material. In this study, the effectiveness of HA microparticles as a carrier system for...
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Optimal technique and response of doxorubicin beads in hepatocellular cancer: bead size and dose

Martin R, Irurzun J, Munchart J, Trofimov I, Scupchenko A, Tatum C, Narayanan

BACKGROUND/AIMS: It has been shown that the drug-eluting beads loaded with doxorubicin (DEBDOX) are effective for the treatment of hepatocellular carcinoma (HCC). However, the optimal safety and efficacy still remain...
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Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis

Kang SS, Choi SH

  • KMID: 1103509
  • J Vet Sci.
  • 2001 Apr;2(1):65-70.
This study demonstrates that prophylactic effect of plaster and cataplasm contained ketoprofen in adjuvant arthritis therapy by X-ray. Adjuvant arthritis was induced by a single injection of Freund's complete adjuvant....
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Effectiveness of Subacromial Anti-Adhesive Agent Injection after Arthroscopic Rotator Cuff Repair: Prospective Randomized Comparison Study

Oh CH, Oh JH, Kim SH, Cho JH, Yoon JP, Kim JY

BACKGROUND: Arthroscopic rotator cuff repair generally has a good clinical outcome but shoulder stiffness after surgery due to subacromial adhesion is one of the most common and clinically important complications....
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