- Discovery of a New DNA Gyrase A Inhibitor, 4-[(1-methyl-6-nitroquinolin-1-ium-4-yl)amino]-N-[4-[(1-methylpyridin-1-ium-4-yl)amino]phenyl]benzamide
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Seo I, Suh SI, Suh MH, Baek WK
- KMID: 2399977
- J Bacteriol Virol.
- 2017 Dec;47(4):179-188.
- doi: 10.4167/jbv.2017.47.4.179
Escherichia coli (E. coli) is a clinically important causative organism that can lead to urinary tract infections. Quinolone antibiotics are among the first-line treatments for urinary tract infections. However, the... -
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- Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea
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Kim IS, Lee NY, Kim S, Ki CS, Kim SH
- KMID: 1106455
- Yonsei Med J.
- 2011 Jan;52(1):188-191.
- doi: 10.3349/ymj.2011.52.1.188
Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs > or = 0.5 microg/mL). These six isolates had no significant quinolone... -
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- Antimicrobial resistance profiles of vancomycin-resistant Enterococcus species isolated from laboratory mice
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Yamanaka H, Kadomatsu , Takagi T, Ohsawa M, Yamamoto N, Kubo N, Takemoto T, Ohsawa K
- KMID: 2454015
- J Vet Sci.
- 2019 Mar;20(2):e13.
- doi: 10.4142/jvs.2019.20.e13
Isolates of 24 enterococci, 5 Enterococcus casseliflavus and 19 Enterococcus gallinarum, possessing vanC genes and showing low-level resistance to vancomycin were obtained from mice from commercial mouse breeding companies. Since... -
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- Antibacterial and Pharmacological Evaluation of Fluoroquinolones: A Chemoinformatics Approach
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Sood D, Kumar N, Singh A, Sakharkar , Tomar V, Chandra R
- KMID: 2422811
- Genomics Inform.
- 2018 Sep;16(3):44-51.
- doi: 10.5808/GI.2018.16.3.44
Fluoroquinolone (FQ) antibiotics are an important class of synthetic antibacterial agents. These are the most extensively used drugs for treating bacterial infections in the field of both human and veterinary... -
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- A Novel Mismatched PCR-Restriction Fragment Length Polymorphism Assay for Rapid Detection of gyrA and parC Mutations Associated With Fluoroquinolone Resistance in Acinetobacter baumannii
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Kakuta N, Nakano R, Nakano A, Suzuki Y, Tanouchi A, Masui T, Horiuchi S, Endo S, Kakuta R, Ono Y, Yano H
- KMID: 2457490
- Ann Lab Med.
- 2020 Jan;40(1):27-32.
- doi: 10.3343/alm.2020.40.1.27
BACKGROUND: Mutations in the quinolone resistance-determining regions (QRDRs) of Acinetobacter baumannii DNA gyrase (gyrA) and topoisomerase IV (parC) are linked to fluoroquinolone (FQ) resistance. We developed a mismatched PCR-restriction fragment... -
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- Characterization of antimicrobial resistance and application of RFLP for epidemiological monitoring of thermophilic Campylobacter spp. isolated from dogs and humans in Korea
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Cho HH, Kim SH, Min W, Ku BK, Kim JH, Kim YH
- KMID: 2307875
- Korean J Vet Res.
- 2014 Jun;54(2):91-99.
An antimicrobial susceptibility test was conducted to compare the resistance rates among Campylobacter spp. isolates from dogs (n = 50) raised under diverse conditions and humans (n = 50). More... -
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- The Drug Resistance Profile of Mycobacterium abscessus Group Strains from Korea
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Lee SH, Yoo HK, Kim SH, Koh WJ, Kim CK, Park YK, Kim HJ
- KMID: 1781357
- Ann Lab Med.
- 2014 Jan;34(1):31-37.
- doi: 10.3343/alm.2014.34.1.31
BACKGROUND: Bacteria of the Mycobacterium abscessus group are the second most common pathogens responsible for lung disease caused by nontuberculous mycobacteria in Korea. There is still a lack of studies... -
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- Inappropriateness of Quinolone in Scrub Typhus Treatment Due to gyrA Mutation in Orientia tsutsugamushi Boryong Strain
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Jang HC, Choi SM, Jang MO, Ahn JH, Kim UJ, Kang SJ, Shin JH, Choy HE, Jung SI, Park KH
- KMID: 1777552
- J Korean Med Sci.
- 2013 May;28(5):667-671.
- doi: 10.3346/jkms.2013.28.5.667
The use of quinolone for treatment of rickettsial diseases remains controversial. Recent clinical studies suggest that quinolone is not as effective as others in patients with rickettsial diseases including scrub... -
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- Mycobacterial Infection after Intravesical Bacillus Calmette-Guerin Treatment for Bladder Cancer: A Case Report
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Park CH, Jang MA, Ahn YH, Hwang YY, Ki CS, Lee NY
- KMID: 1735854
- Korean J Lab Med.
- 2011 Jul;31(3):197-200.
- doi: 10.3343/kjlm.2011.31.3.197
Bacillus Calmette-Guerin (BCG) has been traditionally used as a vaccine against tuberculosis. Further, intravesical administration of BCG has been shown to be effective in treating bladder cancer. Although BCG contains... -
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- Bacteremia Caused by Corynebacterium amycolatum with a Novel Mutation in gyrA Gene that Confers High-Level Quinolone Resistance
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Yoon S, Kim H, Lee Y, Kim S
- KMID: 1096660
- Korean J Lab Med.
- 2011 Jan;31(1):47-48.
- doi: 10.3343/kjlm.2011.31.1.47
Although Corynebacterium amycolatum can cause opportunistic infections, it is commonly considered as contaminant. In this report, we present a case of bacteremia caused by C. amycolatum with a novel mutation... -
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- Antimicrobial Resistance Determinants in Imipenem-nonsusceptible Acinetobacter calcoaceticus-baumannii Complex Isolated in Daejeon, Korea
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Sung JY, Kwon KC, Cho HH, Koo SH
- KMID: 1781690
- Korean J Lab Med.
- 2011 Oct;31(4):265-270.
- doi: 10.3343/kjlm.2011.31.4.265
BACKGROUND: Members of the Acinetobacter calcoaceticus-baumannii (Acb) complex are important opportunistic bacterial pathogens and present significant therapeutic challenges in the treatment of nosocomial infections. In the present study, we investigated... -
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