Yonsei Med J.  2011 Jan;52(1):188-191. 10.3349/ymj.2011.52.1.188.

Reduced Levofloxacin Susceptibility in Clinical Respiratory Isolates of Haemophilus Influenzae Is Not yet Associated with Mutations in the DNA Gyrase and Topoisomerase II Genes in Korea

• Kim IS
• Lee NY
• Kim S
• Ki CS
• Kim SH

• KMID: 1106455
• DOI: http://doi.org/10.3349/ymj.2011.52.1.188

Abstract

Among 155 clinical respiratory isolates of Haemophilus influenzae in Korea, 6 (3.9%) isolates had reduced levofloxacin susceptibility (MICs > or = 0.5 microg/mL). These six isolates had no significant quinolone resistance-determining region (QRDR) mutations in gyrA, gyrB, parC, or parE. This phenomenon suggests that neither evolution nor spread of any significant QRDRs mutations in clinical isolates occurred in Korea. Therefore, continued surveillance is necessary to observe the evolution of antibiotic-resistance and take measures to avoid the spread of drug-resistant clones.

Keyword

Haemophilus influenzae; levofloxacin; quinolone; drug resistance; DNA gyrase; DNA topoisomerases; Type II

MeSH Terms

Anti-Bacterial Agents/*pharmacology
DNA Gyrase/*genetics
DNA Topoisomerases, Type II/*genetics
Haemophilus influenzae/*drug effects/pathogenicity
Korea
Microbial Sensitivity Tests
Mutation
Ofloxacin/*pharmacology

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