- Molecular biomarker testing for non–small cell lung cancer: consensus statement of the Korean Cardiopulmonary Pathology Study Group
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Chang S, Shim HS, Kim TJ, Choi YL, Kim WS, Shin DH, Kim L, Park HS, Lee GK, Lee CH, Korean Cardiopulmonary Pathology Study Group
- KMID: 2515923
- J Pathol Transl Med.
- 2021 May;55(3):181-191.
- doi: 10.4132/jptm.2021.03.23
Molecular biomarker testing is the standard of care for non–small cell lung cancer (NSCLC) patients. In 2017, the Korean Cardiopulmonary Pathology Study Group and the Korean Molecular Pathology Study Group... -
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- TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis
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Jung K, Choi JS, Koo BM, Kim YJ, Song JY, Sung M, Chang ES, Noh KW, An S, Lee MS, Song K, Lee H, Kim RN, Shin YK, Oh DY, Choi YL
- KMID: 2510643
- Cancer Res Treat.
- 2021 Jan;53(1):9-24.
- doi: 10.4143/crt.2020.434
Purpose To find biomarkers for disease, there have been constant attempts to investigate the genes that differ from those in the disease groups. However, the values that lie outside the overall... -
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- Current status and future perspectives of liquid biopsy in non-small cell lung cancer
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Chang S, Hur JY, Choi YL, Lee CH, Kim WS
- KMID: 2501655
- J Pathol Transl Med.
- 2020 May;54(3):204-212.
- doi: 10.4132/jptm.2020.02.27
With advances in target therapy, molecular analysis of tumors is routinely required for treatment decisions in patients with advanced non-small cell lung cancer (NSCLC). Liquid biopsy refers to the sampling... -
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- Differences of Personality Characteristics According to the Suicide Symptoms in Patients with Depression
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Choi YL, Oh MA, Lee SM, Kim JW, Kang WS
- KMID: 2470705
- Korean J Psychosom Med.
- 2019 Dec;27(2):164-172.
- doi: 10.22722/KJPM.2019.27.2.164
OBJECTIVES: The purpose of this study was to examine personality traits associated with suicidal symptoms (with history of suicide attempt or suicidal idea) in depressed patients. METHODS: A sample 186 patients... -
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- Interobserver Reproducibility of PD-L1 Biomarker in Non-small Cell Lung Cancer: A Multi-Institutional Study by 27 Pathologists
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Chang S, Park HK, Choi YL, Jang SJ, Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists
- KMID: 2465433
- J Pathol Transl Med.
- 2019 Nov;53(6):347-353.
- doi: 10.4132/jptm.2019.09.29
BACKGROUND: Assessment of programmed cell death-ligand 1 (PD-L1) immunohistochemical staining is used for treatment decisions in non-small cell lung cancer (NSCLC) regarding use of PD-L1/programmed cell death protein 1 (PD-1)... -
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- Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group
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Shin DH, Shim HS, Kim TJ, Park HS, Choi YL, Kim WS, Kim L, Chang SH, Song JS, Kim HJ, Han JH, Lee CH, Lee GK, Jang SJ, Korean Cardiopulmonary Pathology Study Group
- KMID: 2449337
- J Pathol Transl Med.
- 2019 May;53(3):153-158.
- doi: 10.4132/jptm.2019.02.22
Liquid biopsy for detection of mutation from circulating tumor DNA is a new technology which is attractive in that it is non-invasive. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors... -
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- Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea
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Byeon S, Kim Y, Lim SW, Cho JH, Park S, Lee J, Sun JM, Choi YL, Lee SH, Ahn JS, Park K, Ahn MJ
- KMID: 2464409
- Cancer Res Treat.
- 2019 Apr;51(2):623-631.
- doi: 10.4143/crt.2018.151
PURPOSE: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for approximately 4% of all EGFR mutations. Given the rarity of this mutation, its clinical outcomes are not fully... -
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- EGFR Mutation Is Associated with Short Progression-Free Survival in Patients with Stage III Non-squamous Cell Lung Cancer Treated with Concurrent Chemoradiotherapy
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Park SE, Noh JM, Kim YJ, Lee HS, Cho JH, Lim SW, Ahn YC, Pyo H, Choi YL, Han J, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ
- KMID: 2464396
- Cancer Res Treat.
- 2019 Apr;51(2):493-501.
- doi: 10.4143/crt.2018.125
PURPOSE: This study was conducted to evaluate the relationship between epidermal growth factor receptor (EGFR) mutation and clinical outcomes in patients with stage III non-squamous cell lung cancer treated with... -
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- Abrupt Dyskeratotic and Squamoid Cells in Poorly Differentiated Carcinoma: Case Study of Two Thoracic NUT Midline Carcinomas with Cytohistologic Correlation
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Lee T, Choi S, Han J, Choi YL, Lee K
- KMID: 2422103
- J Pathol Transl Med.
- 2018 Sep;52(5):349-353.
- doi: 10.4132/jptm.2018.07.16
Cytologic diagnosis of nuclear protein in testis (NUT) midline carcinoma (NMC) is important due to its aggressive behavior and miserable prognosis. Early diagnosis of NMC can facilitate proper management, and... -
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- Distribution and survival of primary sarcoma in Korea: A single center analysis of 2017 cases
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Jo SJ, Kim KS, Lee KW, Park JB, Choi YL, Yu JI, Lee SJ, Choi DI, Kim SJ
- KMID: 2416319
- Korean J Clin Oncol.
- 2018 Jun;14(1):30-36.
- doi: 10.14216/kjco.18005
PURPOSE: Distribution and survival of sarcoma in Korea are not well described, after the changing of sarcoma classification on 2013. The researchers investigated the distribution and survival in single center... -
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- Anaplastic lymphoma kinase (ALK)-expressing Lung Adenocarcinoma with Combined Neuroendocrine Component or Neuroendocrine Transformation: Implications for Neuroendocrine Transformation and Response to ALK-tyrosine Kinase Inhibitors
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Sim J, Kim H, Hyeon J, Choi YL, Han J
- KMID: 2408058
- J Korean Med Sci.
- 2018 Apr;33(15):e123.
- doi: 10.3346/jkms.2018.33.e123
BACKGROUND: Anaplastic lymphoma kinase tyrosine kinase inhibitors (ALK-TKIs) are usually effective in lung adenocarcinoma patients with anaplastic lymphoma kinase (ALK) rearrangement. However, even after a good response to ALK-TKI therapy,... -
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- Retrospective Molecular Epidemiology Study of PD-L1 Expression in Patients with EGFR-Mutant Non-small Cell Lung Cancer
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Cho JH, Zhou W, Choi YL, Sun JM, Choi H, Kim TE, Dolled-Filhart M, Emancipator K, Rutkowski , Kim J
- KMID: 2403478
- Cancer Res Treat.
- 2018 Jan;50(1):95-102.
- doi: 10.4143/crt.2016.591
PURPOSE: Data are limited on programmed death ligand 1 (PD-L1) expression in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: We retrospectively evaluated the relationship between... -
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- Prevalence of Mutations in Discoidin Domain-Containing Receptor Tyrosine Kinase 2 (DDR2) in Squamous Cell Lung Cancers in Korean Patients
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Lee MS, Jung EA, An SB, Kim YJ, Oh DY, Song JY, Um SW, Han J, Choi YL
- KMID: 2394825
- Cancer Res Treat.
- 2017 Oct;49(4):1065-1076.
- doi: 10.4143/crt.2016.347
PURPOSE: The discoidin domain-containing receptor tyrosine kinase 2 (DDR2) is known to contain mutations in a small subset of patients with squamous cell carcinomas (SCC) of the lung. Studying the... -
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- Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies
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Heo EJ, Cho YJ, Cho WC, Hong JE, Jeon HK, Oh DY, Choi YL, Song SY, Choi JJ, Bae DS, Lee YY, Choi CH, Kim TJ, Park WY, Kim BG, Lee JW
- KMID: 2394811
- Cancer Res Treat.
- 2017 Oct;49(4):915-926.
- doi: 10.4143/crt.2016.322
PURPOSE: Patient-derived tumor xenografts (PDXs) can provide more reliable information about tumor biology than cell line models. We developed PDXs for epithelial ovarian cancer (EOC) that have histopathologic and genetic... -
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- Metastatic Squamous Cell Carcinoma from Lung Adenocarcinoma after Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy
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Park HK, Seo Y, Choi YL, Ahn MJ, Han J
- KMID: 2392587
- J Pathol Transl Med.
- 2017 Jul;51(4):441-443.
- doi: 10.4132/jptm.2016.10.18
No abstract available. -
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- Molecular Testing of Lung Cancers
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Shim HS, Choi YL, Kim L, Chang S, Kim WS, Roh MS, Kim TJ, Ha SY, Chung JH, Jang SJ, Lee GK, The Korean Cardiopulmonary Pathology Study Group, The Korean Molecular Pathology Study Group
- KMID: 2392592
- J Pathol Transl Med.
- 2017 May;51(3):242-254.
- doi: 10.4132/jptm.2017.04.10
Targeted therapies guided by molecular diagnostics have become a standard treatment of lung cancer. Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are currently used as... -
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- Good Laboratory Standards for Clinical Next-Generation Sequencing Cancer Panel Tests
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Kim J, Park WY, Kim NK, Jang SJ, Chun SM, Sung CO, Choi J, Ko YH, Choi YL, Shim HS, Won JK, The Molecular Pathology Study Group of Korean Society of Pathologists
- KMID: 2392589
- J Pathol Transl Med.
- 2017 May;51(3):191-204.
- doi: 10.4132/jptm.2017.03.14
Next-generation sequencing (NGS) has recently emerged as an essential component of personalized cancer medicine due to its high throughput and low per-base cost. However, no sufficient guidelines for implementing NGS... -
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- Transformation to Small Cell Lung Cancer of Pulmonary Adenocarcinoma: Clinicopathologic Analysis of Six Cases
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Ahn S, Hwang SH, Han J, Choi YL, Lee SH, Ahn JS, Park K, Ahn MJ, Park WY
- KMID: 2345547
- J Pathol Transl Med.
- 2016 Jul;50(4):258-263.
- doi: 10.4132/jptm.2016.04.19
BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are considered the first line treatment for a subset of EGFR-mutated non-small cell lung cancer (NSCLC) patients. Although transformation to... -
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- Risk Factors of Cage Subsidence after Posterior Lumbar Interbody Fusion
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Lee DY, Jeong ST, Hong CH, Choi YL, Kang BH, Kim DH
- KMID: 2328003
- J Korean Soc Spine Surg.
- 2016 Jun;23(2):100-107.
- doi: 10.4184/jkss.2016.23.2.100
STUDY DESIGN: Retrospective study. OBJECTIVES: The purpose of this study was to evaluate risk factors for subsidence after posterior lumbar interbody fusion (PLIF). SUMMARY OF LITERATURE REVIEW: Body mass index (BMI), bone... -
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- Non-small Cell Lung Cancer with Concomitant EGFR, KRAS, and ALK Mutation: Clinicopathologic Features of 12 Cases
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Lee T, Lee B, Choi YL, Han J, Ahn MJ, Um SW
- KMID: 2164596
- J Pathol Transl Med.
- 2016 May;50(3):197-203.
- doi: 10.4132/jptm.2016.03.09
BACKGROUND: Although epidermal growth factor receptor (EGFR), v-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS), and anaplastic lymphoma kinase (ALK) mutations in non-small cell lung cancer (NSCLC) were thought to be... -
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