Korean J Pathol.  1998 Nov;32(11):1028-1031.

Soft Tissue Perineurioma

• Choi YL
• Kim DS
• Go JH
• Suh YL

Abstract

Perineurial cells, which normally surround the nerve fascicles within a nerve, can be distinguished from Schwann cells by their immunoreactivity for epithelial membrane antigen (EMA) and lack of reactivity for S-100 protein. Perineurioma is a form of benign peripheral nerve sheath tumor (PNST) almost exclusively composed of perineurial cells. It is often difficult to differentiate this tumor from the other benign PNSTs or ectopic meningioma by histology alone. Immunohistochemical and electron microscopic studies are helpful for differential diagnosis. We recently experienced a case of soft tissue perineurioma in a 14-year-old girl. This tumor was presented as a 5.6 cm sized subcutaneous movable mass in the elbow. The well encapsulated soft tissue tumor consisted of spindle cells which have whorling and storiform patterns within the collagenous stroma. The spindle cells were stained positive for EMA but negative for S-100 protein, chromogranin, neuron-specific enolase or Leu-7. Ultrastructurally, they possessed long cytoplasmic processes with incomplete basal lamina, primitive intercellular junction and occasional pinocytotic vesicles.

Keyword

Peripheral nerve sheath tumor; Perineurioma; Immunohistochemistry; Electron microscopy

MeSH Terms

Adolescent
Basement Membrane
Collagen
Cytoplasm
Diagnosis, Differential
Elbow
Female
Humans
Immunohistochemistry
Intercellular Junctions
Meningioma
Microscopy, Electron
Mucin-1
Nerve Sheath Neoplasms*
Peripheral Nerves
Phosphopyruvate Hydratase
S100 Proteins
Schwann Cells
Collagen
Mucin-1
Phosphopyruvate Hydratase
S100 Proteins