- Clinical Characteristics and Treatment of Immune-Related Adverse Events of Immune Checkpoint Inhibitors
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Choi J, Lee SY
- KMID: 2471049
- Immune Netw.
- 2020 Feb;20(1):e9.
- doi: 10.4110/in.2020.20.e9
Immune checkpoint inhibitors (ICIs) have been changing the paradigm of cancer treatment. However, immune-related adverse effects (irAEs) have also increased with the exponential increase in the use of ICIs. ICIs... -
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- Mycophenolate Mofetil Overdose Induced Ventricular Tachycardia in a Patient with Systemic Lupus Erythematosus
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Kim JH, Chung H, Lee KA, Kim HR, Lee SH
- KMID: 2462832
- Korean J Med.
- 2019 Oct;94(5):455-458.
- doi: 10.3904/kjm.2019.94.5.455
Mycophenolate mofetil (MMF) is an immunosuppressive agent used to treat severe lupus, including lupus nephritis. Common adverse effects of MMF include gastrointestinal and hematological manifestations; however, cardiac toxicity in association... -
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- An effective patient training for deep inspiration breath hold technique of left-sided breast on computed tomography simulation procedure at King Chulalongkorn Memorial Hospital
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Oonsiri P, Wisetrinthong M, Chitnok M, Saksornchai K, Suriyapee
- KMID: 2460745
- Radiat Oncol J.
- 2019 Sep;37(3):201-206.
- doi: 10.3857/roj.2019.00290
PURPOSE: To observe the effectiveness of the practical instruction sheet and the educational video for left-sided breast treatment in a patient receiving deep inspiration breath hold (DIBH) technique. Two parameters,... -
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- Antitumor profiles and cardiac electrophysiological effects of aurora kinase inhibitor ZM447439
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Lee HA, Kwon M, Kim HA, Kim KS
- KMID: 2455815
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):393-402.
- doi: 10.4196/kjpp.2019.23.5.393
Aurora kinases inhibitors, including ZM447439 (ZM), which suppress cell division, have attracted a great deal of attention as potential novel anti-cancer drugs. Several recent studies have confirmed the anti-cancer effects... -
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- Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart
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Okada JI, Washio T, Sugiura S, Hisada T
- KMID: 2455805
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):295-303.
- doi: 10.4196/kjpp.2019.23.5.295
A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and... -
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- Early Decline in Left Ventricular Ejection Fraction Can Predict Trastuzumab-Related Cardiotoxicity in Patients with Breast Cancer: A Study Using 13 Years of Registry Data
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Kim EK, Cho J, Kim JY, Chang SA, Park SJ, Choi JO, Lee SC, Ahn JS, Park SW, Im YH, Jeon ES, Park YH
- KMID: 2464418
- Cancer Res Treat.
- 2019 Apr;51(2):727-736.
- doi: 10.4143/crt.2018.262
PURPOSE: While concerns regarding trastuzumab-related cardiac dysfunction (TRCD) in patients with breast cancer are increasing, there is a lack of evidence supporting the current recommendations for TRCD monitoring. We aimed... -
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- Biochemical effects and safety of Gum arabic (Acacia Senegal) supplementation in patients with sickle cell anemia
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Kaddam LA, Fdl-Elmula I, Eisawi OA, Abdelrazig HA, Elnimeiri , Saeed AM
- KMID: 2451053
- Blood Res.
- 2019 Mar;54(1):31-37.
- doi: 10.5045/br.2019.54.1.31
BACKGROUND: Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several clinical consequences. Intravascular sickling of red blood cells leads to multi-organ dysfunction. Moreover, several biochemical abnormalities have... -
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- Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative
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Park JS, Jeon JY, Yang JH, Kim MG
- KMID: 2442241
- Transl Clin Pharmacol.
- 2019 Mar;27(1):12-18.
- doi: 10.12793/tcp.2019.27.1.12
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human... -
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- Risk Factor Analysis for Secondary Malignancy in Dexrazoxane-Treated Pediatric Cancer Patients
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Kim H, Kang HJ, Park KD, Koh KN, Im HJ, Seo JJ, Lee JW, Chung NG, Cho B, Kim HK, Lee JM, Hah JO, Lee JA, Lee YH, Park SK, Baek HJ, Kook H, Kim JY, Kim HS, Kim HM, Chueh HW, Park M, Yoon HS, Lee MJ, Choi HS, Ahn HS, Kawano Y, Park JW, Hahn S, Shin HY
- KMID: 2437626
- Cancer Res Treat.
- 2019 Jan;51(1):357-367.
- doi: 10.4143/crt.2017.457
PURPOSE: Dexrazoxane has been used as an effective cardioprotector against anthracycline cardiotoxicity. This study intended to analyze cardioprotective efficacy and secondary malignancy development, and elucidate risk factors for secondary malignancies... -
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- Correlation of UGT2B7 Polymorphism with Cardiotoxicity in Breast Cancer Patients Undergoing Epirubicin/Cyclophosphamide-Docetaxel Adjuvant Chemotherapy
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Li H, Hu B, Guo Z, Jiang X, Su X, Zhang X
- KMID: 2428275
- Yonsei Med J.
- 2019 Jan;60(1):30-37.
- doi: 10.3349/ymj.2019.60.1.30
PURPOSE: The present study aimed to investigate correlations between uridine glucuronosyltransferase 2B7 (UGT2B7) -161 single nucleotide polymorphism C to T (C>T) and the occurrence of cardiotoxicity in Chinese breast cancer... -
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- Long-term cardiac composite risk following adjuvant treatment in breast cancer patients
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Choi HB, Yun S, Cho SW, Lee MH, Lee J, Park S
- KMID: 2432607
- Korean J Clin Oncol.
- 2018 Dec;14(2):102-107.
- doi: 10.14216/kjco.18018
PURPOSE: Cardiotoxicity is a serious late complication of breast cancer treatment. Individual treatment risk of specific drugs has been investigated. However, studies on the evaluation of the composite risk of... -
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- Which Patients with Left Breast Cancer Should be Candidates for Heart-Sparing Radiotherapy?
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Cho WK, Park W, Choi DH, Cha H, Nam SJ, Kim SW, Lee JE, Yu J, Im YH, Ahn JS, Park YH, Kim JY
- KMID: 2413940
- J Breast Cancer.
- 2018 Jun;21(2):206-212.
- doi: 10.4048/jbc.2018.21.2.206
PURPOSE: This study aimed to identify risk factors that have significant interaction with radiation exposure to the heart, and thus to determine candidates for heart-sparing radiotherapy (RT) among women with... -
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- A Case of Successfully Treated Severe Heart Failure due to Cyclophosphamide Induced Cardiomyopathy
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Park JM, Hahn SM, Han JW, Lyu CJ
- KMID: 2435428
- Clin Pediatr Hematol Oncol.
- 2018 Apr;25(1):71-75.
- doi: 10.15264/cpho.2018.25.1.71
Cyclophosphamide-induced cardiotoxicity is an uncommon complication especially in patients who have never undergone mediastinal irradiation or cardiotoxic chemotherapy and do not have underlying cardiac diseases. Here, we describe the case... -
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- Diagnosis, Treatment, and Prevention of Cardiovascular Toxicity Related to Anti-Cancer Treatment in Clinical Practice: An Opinion Paper from the Working Group on Cardio-Oncology of the Korean Society of Echocardiography
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Kim H, Chung WB, Cho KI, Kim BJ, Seo JS, Park SM, Kim HJ, Lee JH, Kim EK, Youn HJ
- KMID: 2407677
- J Cardiovasc Ultrasound.
- 2018 Mar;26(1):1-25.
- doi: 10.4250/jcu.2018.26.1.1
Cardiovascular (CV) toxicity associated with anti-cancer treatment is commonly encountered and raises critical problems that often result in serious morbidity or mortality. Most cardiac toxicities are related to the cumulative... -
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- Loss of endogenous estrogen increases cardiac toxicity by doxorubicin
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Lee YH, Lee SR, Kwon SW, Lee SY, Park BK, Hong EJ
- KMID: 2405359
- J Biomed Transl Res.
- 2017 Dec;18(4):146-150.
- doi: 10.12729/jbtr.2017.18.4.146
Breast cancer is of enormous concern worldwide and linked with age, sex, hormonal factors, and family history. The treatment of early breast cancer includes treating the disease locally with surgery,... -
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- Comparision of doxorubicin-induced cardiotoxicity in the ICR mice of different sources
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Kim SH, Kim KJ, Kim JH, Kwak JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS
- KMID: 2407431
- Lab Anim Res.
- 2017 Jun;33(2):165-170.
- doi: 10.5625/lar.2017.33.2.165
Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast,... -
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- A Fatal Case of Colchicine Poisoning
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Ko SH, Lee GW
- KMID: 2386866
- J Korean Soc Clin Toxicol.
- 2017 Jun;15(1):51-55.
- doi: 10.22537/jksct.2017.15.1.51
Colchicine is a drug that has long been used to treat a variety of illnesses; however, it reportedly has adverse effects at apparent toxic doses as well as at lower... -
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- Cardioprotective Effect of Dexrazoxane in Patients with HER2-Positive Breast Cancer Who Receive Anthracycline Based Adjuvant Chemotherapy Followed by Trastuzumab
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Kim IH, Lee JE, Youn HJ, Song BJ, Chae BJ
- KMID: 2379402
- J Breast Cancer.
- 2017 Mar;20(1):82-90.
- doi: 10.4048/jbc.2017.20.1.82
PURPOSE: We intended to determine whether dexrazoxane (DZR) is cardioprotective during administration of adjuvant anthracycline-based chemotherapy followed by a 1-year trastuzumab treatment. METHODS: The medical records of 228 patients who underwent... -
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- Ginsenoside Rb1 Inhibits Doxorubicin-Triggered H9C2 Cell Apoptosis via Aryl Hydrocarbon Receptor
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Zhang Y, Wang Y, Ma Z, Liang Q, Tang X, Tan H, Xiao C, Gao Y
- KMID: 2375041
- Biomol Ther.
- 2017 Mar;25(2):202-212.
- doi: 10.4062/biomolther.2016.066
Doxorubicin (DOX) is a highly effective chemotherapeutic agent; however, the dose-dependent cardiotoxicity associated with DOX significantly limits its clinical application. In the present study, we investigated whether Rb1 could prevent... -
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- Chemotherapy-Induced Left Ventricular Dysfunction in Patients with Breast Cancer
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Yoon HJ, Kim KH, Kim JY, Park HJ, Cho JY, Hong YJ, Park HW, Kim JH, Ahn Y, Jeong MH, Cho JG, Park JC
- KMID: 2362926
- J Breast Cancer.
- 2016 Dec;19(4):402-409.
- doi: 10.4048/jbc.2016.19.4.402
PURPOSE: As the numbers of cancer cases and survivors increase, the incidence and natural history of chemotherapy-induced cardiotoxicities in patients with breast cancer may also be expected to change. The... -
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