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Synergetic Hepatoprotective Effects of Korean Red Ginseng and Pueraria Radix on the Liver Damaged-Induced by Carbon Tetrachloride (CClâ‚„) in Mice

Hwang SH, Wang Z, Kang IJ, Lim SS

This study was designed to investigate the synergetic hepatoprotective effects from a mixture of Korean Red Ginseng and Pueraria Radix on carbon tetrachloride (CClâ‚„)-induced hepatotoxicity in mice. Liver toxicity was...
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PXR Mediated Protection against Liver Inflammation by Ginkgolide A in Tetrachloromethane Treated Mice

Ye N, Wang H, Hong J, Zhang T, Lin C, Meng C

The pregnane X receptor (PXR), a liver and intestine specific receptor,, has been reported to be related with the repression of inflammation as well as activation of cytochromosome P450 3A...
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Hepatoprotective effects of Rubus coreanus miquel concentrates on liver injuries induced by carbon tetrachloride in rats

Chae HJ, Yim JE, Kim KA, Chyun JH

  • KMID: 2313709
  • Nutr Res Pract.
  • 2014 Feb;8(1):40-45.
As well-being foods pursuing healthy life are becoming popular, interest in Rubus coreanus Miquel (RCM) fruit, a type of Korean blackberry, is increasing due to its medicinal actions including protecting...
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Pharmacodynamic Changes of Atracurium during Induced Liver Cirrhosis Using Carbon Tetrachloride Intoxication in Rabbits

Kim KS, Jang HS, Cheong MA, Shim JC, Kim KH

BACKGROUND: Atracurium appears to be a neuromuscular blocking agent best suited for use in patients with renal failure. The influence on the neuromuscular effect of atracurium has been studied in...
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Pharmacodynamic Changes of Mivacurium in Liver Cirrhosis Model in Rabbits Using Carbon Tetrachloride Intoxication

Cha YD, Lee HS, Ki HY, Park HJ, Yang CW, Kim YH, Kim KS, Han JU

BACKGROUND: A reproducible animal model of liver cirrhosis by administering multiple doses of carbon tetrachloride (CCl4) is highly desirable for appropriate metabolic and therapeutic studies. The current study was undertaken...
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Pharmacodynamic Changes of Rocuronium during Induced Liver Cirrhosis Using Carbon Tetrachloride Intoxication in Rabbits

Park HS, Son HM, Kim DW, Kim KS

BACKGROUND: A reproducible animal model of liver cirrhosis by carbon tetrachloride (CCl4) is highly desirable for metabolic and therapeutic studies. The current study was undertaken to evaluate the neuromuscular blockade...
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The Change of Transforming Growth Factor-beta1 Expression and the Effect of Vitamin E in the Acute Rat Liver Injury with Carbon Tetrachloride

Lee JI, Lee KS, Chung JP, Park YN, Lee SJ, Han KH, Chon CY, Lee SI, Moon YM, Kim HS

  • KMID: 2241276
  • Korean J Hepatol.
  • 2000 Jun;6(2):147-155.
BACKGROUND/AIMS: The evaluation of the relationship between oxidative stress induced by acute carbon tetrachloride (CCl4) administration and transforming growth factor-beta1 (TGF-beta1), and the investigation of temporal patterns of serum alanine...
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Carbon tetrachloride (CCl4)-induced hepatic fibrosis in the rat

Song IH, Kim BH, Kim YK, Dong SH, Kim HJ, Lee JI, Chang YW, Chang R

  • KMID: 2143797
  • Korean J Gastroenterol.
  • 1992 Dec;24(6):1330-1339.
No abstract available.
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Effect of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride in rat

Byun YS, Nam HJ, Kim MJ, Kim DS, Choi WH, Lee TS

The purpose of this study was to evaluate the influence of phenobarbital (PB) on hepatotoxic effect of carbon tetrachloride (CCI4) which induces centrilobular necrosis in liver. Rats were injected intraperitoneally...
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Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity

Kang YC, Nam HJ, Kim DS, Choi WH, Lee TS

The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver....
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Morphologic Change of Rat Liver Induced by Repeated Administration of Carbon Tetrachloride and Dimethylnitrosamine

Lee TS

Carbon tetrachloride and dimethylnitrosamine, both potent hepatotoxic agents, affect the hepatic lobules with fatty changes and central necrosis, and hemorrhagic necrosis. To study the effects on morphologic changes of the...
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The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes

Han EK, Hong YS, Sung HE, Pae YS

After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were...
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