- Carbon tetrachloride (CCl4)-induced hepatic fibrosis in the rat
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Song IH, Kim BH, Kim YK, Dong SH, Kim HJ, Lee JI, Chang YW, Chang R
- KMID: 2143797
- Korean J Gastroenterol.
- 1992 Dec;24(6):1330-1339.
No abstract available. -
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- Morphologic Change of Rat Liver Induced by Repeated Administration of Carbon Tetrachloride and Dimethylnitrosamine
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Lee TS
- KMID: 2373920
- Yeungnam Univ J Med.
- 1987 Aug;4(1):89-96.
- doi: 10.12701/yujm.1987.4.1.89
Carbon tetrachloride and dimethylnitrosamine, both potent hepatotoxic agents, affect the hepatic lobules with fatty changes and central necrosis, and hemorrhagic necrosis. To study the effects on morphologic changes of the... -
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- Effect of sodium selenite on the hepatotoxicity induced with carbon tetrachloride
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Lee KS, Shin TS, Choi KD
- KMID: 2439775
- Yonsei Med J.
- 1973 Dec;14(1):53-62.
The authors have demonstrated the effect of sodium selenite on the hepatotoxicity due to carbon tetrachloride, by observing the distribution and disaggregation of the pyroninophilic granules in the hepatic cell... -
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- Hypothalamic-Pituitary-Gonadal Function in Hepatic Failure, Experimental Study
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Kim YK, Lee CW, Kim KM, Lee ES, Chung KH, Lee AK, Lee SW
- KMID: 2114875
- Korean J Urol.
- 1988 Aug;29(4):533-537.
Insufficiency of the liver was induced by administration of carbon tetrachloride in Wistar strain rats and its influence on the histopathology of the gonad and its accessories was studied. Plasma... -
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- The Protective Effects of Garlic against Carbon tetrachloride-induced Hepatotoxicity
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Choi BS, Lee JM, Park JD, Hong YP
- KMID: 2283257
- Korean J Prev Med.
- 2002 Aug;35(3):221-228.
OBJECTIVES: The purpose of this study was to find the protective effects of garlic on the halogenated hydrocarbon induced hepatotoxicities, and the possible protection mechanisms involved. METHODS: Male Sprague-Dawley rats received... -
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- Effect of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride in rat
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Byun YS, Nam HJ, Kim MJ, Kim DS, Choi WH, Lee TS
- KMID: 2377612
- Yeungnam Univ J Med.
- 1992 Jun;9(1):137-148.
- doi: 10.12701/yujm.1992.9.1.137
The purpose of this study was to evaluate the influence of phenobarbital (PB) on hepatotoxic effect of carbon tetrachloride (CCI4) which induces centrilobular necrosis in liver. Rats were injected intraperitoneally... -
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- Anti-oxidant activities of kiwi fruit extract on carbon tetrachloride-induced liver injury in mice
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Kang W, Yang H, Hong HJ, Han CH, Lee YJ
- KMID: 1431989
- Korean J Vet Res.
- 2012 Dec;52(4):275-280.
The kiwi (Actinidia deliciosa) is well known to contain anti-oxidants. In this study, we investigated the anti-oxidant effects of kiwi extract on carbon tetrachloride (CCl4) induced liver injury in BALB/c... -
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- Effects of carbon tetrachloride on structures in hepatocytes following DMN induced hepatotoxicity
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Kang YC, Nam HJ, Kim DS, Choi WH, Lee TS
- KMID: 2377363
- Yeungnam Univ J Med.
- 1991 Dec;8(2):84-94.
- doi: 10.12701/yujm.1991.8.2.84
The purpose of this study was to evaluate the influence of high dose carbon tetrachloride (CCI4) on the hepatotoxic effect of dimethylnitrosamine (DMN) which induces acute hemorrhagic necrosis in liver.... -
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- Liver Cells of Cordotomized Rats after Single Doses of Carbon Tetrachloride
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Shin TS, Choi KD
- KMID: 687640
- Yonsei Med J.
- 1970 Dec;11(2):85-94.
- doi: 10.3349/ymj.1970.11.2.85
In attempting to ellucidate the mechanism of action of CCl4 toxicity on the liver, the histobgical and histochemical studies were carried out, at the cellular or ultrastructural level, rats were... -
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- Antifibrotic activity a fermentation filtrate of Ganoderma lucidum
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Kwon SC, Kim YB
- KMID: 1444974
- Lab Anim Res.
- 2011 Dec;27(4):369-371.
- doi: 10.5625/lar.2011.27.4.369
The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl4)-induced hepatic fibrosis were investigated in rats. Male Sprague-Dawley rats were orally administered with FGL (20 or... -
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- Transcriptome Analysis of the Effects of Gomisin A on the Recovery of Carbon Tetrachloride-Induced Damage in Rat Liver
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Choi YM, Choi IS, Lee SM, Hwang DY, Choi YW, Park YH
- KMID: 2053666
- Lab Anim Res.
- 2011 Jun;27(2):161-169.
- doi: 10.5625/lar.2011.27.2.161
Gomisin A possesses a hepatic function-facilitating property in liver-injured rats. Its preventive action on carbon tetrachloride-induced cholestasis is due to maintenance of the function of the bile acids-independent fraction. To... -
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- Synergetic Hepatoprotective Effects of Korean Red Ginseng and Pueraria Radix on the Liver Damaged-Induced by Carbon Tetrachloride (CClâ‚„) in Mice
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Hwang SH, Wang Z, Kang IJ, Lim SS
- KMID: 2387064
- Nat Prod Sci.
- 2017 Jun;23(2):132-138.
- doi: 10.20307/nps.2017.23.2.132
This study was designed to investigate the synergetic hepatoprotective effects from a mixture of Korean Red Ginseng and Pueraria Radix on carbon tetrachloride (CClâ‚„)-induced hepatotoxicity in mice. Liver toxicity was... -
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- Influence of Hepatic Damage on the Male Reproductive Glands: IV. Effect of Cortisone on the Reproductive Glands of Male White Rats with Liver Damage
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Kim YK, Lee HS
- KMID: 2010415
- Korean J Urol.
- 1960 Oct;1(2):111-117.
Young adult male rats were injected with carbon tetrachloride along with cortisone acetate simultaneously and the effect of cortisone acetate on the damage of the liver and the liver's effect... -
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- Pharmacodynamic Changes of Rocuronium during Induced Liver Cirrhosis Using Carbon Tetrachloride Intoxication in Rabbits
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Park HS, Son HM, Kim DW, Kim KS
- KMID: 2239926
- Korean J Anesthesiol.
- 2003 Sep;45(3):371-376.
- doi: 10.4097/kjae.2003.45.3.371
BACKGROUND: A reproducible animal model of liver cirrhosis by carbon tetrachloride (CCl4) is highly desirable for metabolic and therapeutic studies. The current study was undertaken to evaluate the neuromuscular blockade... -
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- A Case of Colchicine-Induced Neutropenia in Liver Cirrhosis Patient
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Lee HC, Lee HJ, Kim YG, Park JH, Kim SJ, Park JS
- KMID: 1469809
- Yeungnam Univ J Med.
- 2009 Dec;26(2):125-129.
- doi: 10.12701/yujm.2009.26.2.125
Colchicine is an alkaloid that has been used for treating acute gouty arthritis, psoriasis, scleroderma and Behcet's syndrome. Colchicine decreased liver fibrosis in rats with carbon tetrachloride induced cirrhosis and... -
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- The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes
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Han EK, Hong YS, Sung HE, Pae YS
- KMID: 2009002
- Ewha Med J.
- 1983 Jun;6(2):57-64.
- doi: 10.12771/emj.1983.6.2.57
After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were... -
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- Influence of Hepatic Damage on the Male Reproductive Glands: II. Influence of Hepatic Damage on the Effect of Exogenous Sex Hormones on the Reproductive Glands of White Rats
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Kim YK, Lee HS
- KMID: 2010413
- Korean J Urol.
- 1960 Oct;1(2):97-104.
Young adults male rats were injected with carbon tetrachloride to induce damage to the liver in order to study the influence of this damage on the effects of exogenous estrogens... -
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- Swertiamarin ameliorates carbon tetrachloride-induced hepatic apoptosis via blocking the PI3K/Akt pathway in rats
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Zhang Q, Chen K, Wu T, Song H
- KMID: 2443612
- Korean J Physiol Pharmacol.
- 2019 Jan;23(1):21-28.
- doi: 10.4196/kjpp.2019.23.1.21
Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CClâ‚„)-induced liver injury and its possible... -
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- Inhibitory Effect of Tetrandrine on Extracellular Matrix Deposition in Rat Hepatic Fibrosis
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Choi WY, Chae HJ, Lee SK
- KMID: 1725543
- Korean J Pathol.
- 1999 May;33(5):319-325.
No effective therapy has yet developed for liver fibrosis/cirrhosis by directly inhibiting the accumulation of extracellular matrix. This study was undertaken to determine the effect of tetrandrine in rat model... -
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- Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride
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Qin G, Ning Y, Su J, Shinozuka , Lotlikar P
- KMID: 755007
- Exp Mol Med.
- 1998 Dec;30(4):186-191.
The effect of carbon tetrachloride (CCl4) on aflatoxin B1 (AFB1)-induced enzyme altered hepatic foci has been examined in young male Fischer rats given AIN-76A diet. A single i.p. dose of... -
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